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    ARHGEF1 Rho guanine nucleotide exchange factor 1 [ Sus scrofa (pig) ]

    Gene ID: 100518073, updated on 8-Mar-2024

    Summary

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    Official Symbol
    ARHGEF1provided by VGNC
    Official Full Name
    Rho guanine nucleotide exchange factor 1provided by VGNC
    Primary source
    VGNC:VGNC:96922
    See related
    Ensembl:ENSSSCG00000003040
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Broad expression in spleen (RPKM 34.1), lung (RPKM 24.6) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See ARHGEF1 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 6 NC_010448.4 (49975957..49995442, complement)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 6 NC_010448.3 (46030643..46046982)

    Chromosome 6 - NC_010448.4Genomic Context describing neighboring genes Neighboring gene Rab acceptor 1 Neighboring gene ETS repressor factor like Neighboring gene uncharacterized LOC110260993 Neighboring gene CD79a molecule Neighboring gene ribosomal protein S19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 1
    Names
    Rho guanine nucleotide exchange factor (GEF) 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010448.4 Reference Sscrofa11.1 Primary Assembly

      Range
      49975957..49995442 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021094443.1 → XP_020950102.1  rho guanine nucleotide exchange factor 1 isoform X3

      UniProtKB/TrEMBL
      A0A287AA62
      Conserved Domains (4) summary
      PHA03418
      Location:537 → 676
      PHA03418; hypothetical E4 protein; Provisional
      smart00325
      Location:686 → 870
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cl02565
      Location:262 → 454
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl17171
      Location:904 → 1028
      PH-like; Pleckstrin homology-like domain

    2. XM_021094441.1 → XP_020950100.1  rho guanine nucleotide exchange factor 1 isoform X1

      UniProtKB/TrEMBL
      A0A287AA62
      Conserved Domains (4) summary
      PHA03418
      Location:537 → 680
      PHA03418; hypothetical E4 protein; Provisional
      smart00325
      Location:690 → 874
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cl02565
      Location:262 → 454
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl17171
      Location:908 → 1032
      PH-like; Pleckstrin homology-like domain

    3. XM_021094444.1 → XP_020950103.1  rho guanine nucleotide exchange factor 1 isoform X4

      UniProtKB/TrEMBL
      A0A287AA62, A0A4X1SFI2
      Related
      ENSSSCP00000040702.2, ENSSSCT00000041398.3
      Conserved Domains (4) summary
      PHA03418
      Location:537 → 676
      PHA03418; hypothetical E4 protein; Provisional
      smart00325
      Location:686 → 870
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cl02565
      Location:262 → 454
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl17171
      Location:904 → 1028
      PH-like; Pleckstrin homology-like domain

    4. XM_021094442.1 → XP_020950101.1  rho guanine nucleotide exchange factor 1 isoform X2

      UniProtKB/TrEMBL
      A0A287AA62, A0A287AJS0, A0A4X1SG16
      Related
      ENSSSCP00000044252.2, ENSSSCT00000045918.3
      Conserved Domains (4) summary
      PHA03418
      Location:537 → 680
      PHA03418; hypothetical E4 protein; Provisional
      smart00325
      Location:690 → 874
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cl02565
      Location:262 → 454
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl17171
      Location:908 → 1032
      PH-like; Pleckstrin homology-like domain

    5. XM_021094445.1 → XP_020950104.1  rho guanine nucleotide exchange factor 1 isoform X5

      UniProtKB/TrEMBL
      A0A4X1SFL4
      Conserved Domains (4) summary
      smart00325
      Location:630 → 814
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cl02565
      Location:262 → 454
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl17171
      Location:848 → 972
      PH-like; Pleckstrin homology-like domain
      cl25865
      Location:512 → 607
      Trypan_PARP; Procyclic acidic repetitive protein (PARP)

    6. XM_021094446.1 → XP_020950105.1  rho guanine nucleotide exchange factor 1 isoform X6

      UniProtKB/TrEMBL
      A0A4X1SFI8, A0A4X1SFL4
      Related
      ENSSSCP00000042573.2, ENSSSCT00000045905.3
      Conserved Domains (4) summary
      smart00325
      Location:630 → 814
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cl02565
      Location:262 → 454
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl17171
      Location:848 → 972
      PH-like; Pleckstrin homology-like domain
      cl25865
      Location:512 → 607
      Trypan_PARP; Procyclic acidic repetitive protein (PARP)

    7. XM_021094459.1 → XP_020950118.1  rho guanine nucleotide exchange factor 1 isoform X12

      UniProtKB/TrEMBL
      A0A4X1SG99
      Conserved Domains (4) summary
      smart00325
      Location:421 → 605
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cl02565
      Location:53 → 245
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl17171
      Location:639 → 763
      PH-like; Pleckstrin homology-like domain
      cl25865
      Location:303 → 398
      Trypan_PARP; Procyclic acidic repetitive protein (PARP)

    8. XM_021094451.1 → XP_020950110.1  rho guanine nucleotide exchange factor 1 isoform X8

      UniProtKB/TrEMBL
      A0A286ZMZ3, A0A4X1SGQ3, A0A8D0JC99, A0A8D1QH12
      Related
      ENSSSCP00000032827.1, ENSSSCT00000066326.3
      Conserved Domains (4) summary
      PHA03418
      Location:328 → 471
      PHA03418; hypothetical E4 protein; Provisional
      smart00325
      Location:481 → 665
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cl02565
      Location:53 → 245
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl17171
      Location:699 → 823
      PH-like; Pleckstrin homology-like domain

    9. XM_021094447.1 → XP_020950106.1  rho guanine nucleotide exchange factor 1 isoform X7

      UniProtKB/TrEMBL
      A0A480EC91, A0A8D0NR98, A0A8D1QH12
      Conserved Domains (4) summary
      PHA03418
      Location:328 → 471
      PHA03418; hypothetical E4 protein; Provisional
      smart00325
      Location:481 → 665
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cl02565
      Location:53 → 245
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl17171
      Location:699 → 823
      PH-like; Pleckstrin homology-like domain

    10. XM_005655907.3 → XP_005655964.2  rho guanine nucleotide exchange factor 1 isoform X11

      UniProtKB/TrEMBL
      A0A4X1SG99
      Related
      ENSSSCP00000053703.2, ENSSSCT00000042668.3
      Conserved Domains (4) summary
      smart00325
      Location:421 → 605
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cl02565
      Location:53 → 245
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl17171
      Location:639 → 763
      PH-like; Pleckstrin homology-like domain
      cl25865
      Location:303 → 398
      Trypan_PARP; Procyclic acidic repetitive protein (PARP)

    11. XM_021094455.1 → XP_020950114.1  rho guanine nucleotide exchange factor 1 isoform X8

      UniProtKB/TrEMBL
      A0A286ZMZ3, A0A4X1SGQ3, A0A8D0JC99, A0A8D1QH12
      Conserved Domains (4) summary
      PHA03418
      Location:328 → 471
      PHA03418; hypothetical E4 protein; Provisional
      smart00325
      Location:481 → 665
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cl02565
      Location:53 → 245
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl17171
      Location:699 → 823
      PH-like; Pleckstrin homology-like domain

    12. XM_021094450.1 → XP_020950109.1  rho guanine nucleotide exchange factor 1 isoform X7

      UniProtKB/TrEMBL
      A0A480EC91, A0A8D0NR98, A0A8D1QH12
      Conserved Domains (4) summary
      PHA03418
      Location:328 → 471
      PHA03418; hypothetical E4 protein; Provisional
      smart00325
      Location:481 → 665
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cl02565
      Location:53 → 245
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl17171
      Location:699 → 823
      PH-like; Pleckstrin homology-like domain

    13. XM_021094456.1 → XP_020950115.1  rho guanine nucleotide exchange factor 1 isoform X9

      UniProtKB/TrEMBL
      A0A8D0NMJ8, A0A8D1U2K8
      Conserved Domains (4) summary
      PHA03418
      Location:328 → 467
      PHA03418; hypothetical E4 protein; Provisional
      smart00325
      Location:477 → 661
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cl02565
      Location:53 → 245
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl17171
      Location:695 → 819
      PH-like; Pleckstrin homology-like domain

    14. XM_021094449.1 → XP_020950108.1  rho guanine nucleotide exchange factor 1 isoform X7

      UniProtKB/TrEMBL
      A0A480EC91, A0A8D0NR98, A0A8D1QH12
      Conserved Domains (4) summary
      PHA03418
      Location:328 → 471
      PHA03418; hypothetical E4 protein; Provisional
      smart00325
      Location:481 → 665
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cl02565
      Location:53 → 245
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl17171
      Location:699 → 823
      PH-like; Pleckstrin homology-like domain

    15. XM_021094448.1 → XP_020950107.1  rho guanine nucleotide exchange factor 1 isoform X7

      UniProtKB/TrEMBL
      A0A480EC91, A0A8D0NR98, A0A8D1QH12
      Conserved Domains (4) summary
      PHA03418
      Location:328 → 471
      PHA03418; hypothetical E4 protein; Provisional
      smart00325
      Location:481 → 665
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cl02565
      Location:53 → 245
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl17171
      Location:699 → 823
      PH-like; Pleckstrin homology-like domain

    16. XM_021094460.1 → XP_020950119.1  rho guanine nucleotide exchange factor 1 isoform X12

      UniProtKB/TrEMBL
      A0A4X1SG99
      Conserved Domains (4) summary
      smart00325
      Location:421 → 605
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cl02565
      Location:53 → 245
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl17171
      Location:639 → 763
      PH-like; Pleckstrin homology-like domain
      cl25865
      Location:303 → 398
      Trypan_PARP; Procyclic acidic repetitive protein (PARP)

    17. XM_021094458.1 → XP_020950117.1  rho guanine nucleotide exchange factor 1 isoform X11

      UniProtKB/TrEMBL
      A0A4X1SG99
      Conserved Domains (4) summary
      smart00325
      Location:421 → 605
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cl02565
      Location:53 → 245
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl17171
      Location:639 → 763
      PH-like; Pleckstrin homology-like domain
      cl25865
      Location:303 → 398
      Trypan_PARP; Procyclic acidic repetitive protein (PARP)

    18. XM_021094457.1 → XP_020950116.1  rho guanine nucleotide exchange factor 1 isoform X10

      UniProtKB/TrEMBL
      A0A5G2QAW6, A0A8D0TNE9, A0A8D1U2K8
      Related
      ENSSSCP00000060554.1, ENSSSCT00000076130.2
      Conserved Domains (4) summary
      PHA03418
      Location:328 → 467
      PHA03418; hypothetical E4 protein; Provisional
      smart00325
      Location:477 → 661
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cl02565
      Location:53 → 245
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl17171
      Location:695 → 819
      PH-like; Pleckstrin homology-like domain

    19. XM_021094454.1 → XP_020950113.1  rho guanine nucleotide exchange factor 1 isoform X8

      UniProtKB/TrEMBL
      A0A286ZMZ3, A0A4X1SGQ3, A0A8D0JC99, A0A8D1QH12
      Conserved Domains (4) summary
      PHA03418
      Location:328 → 471
      PHA03418; hypothetical E4 protein; Provisional
      smart00325
      Location:481 → 665
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cl02565
      Location:53 → 245
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl17171
      Location:699 → 823
      PH-like; Pleckstrin homology-like domain

    20. XM_021094452.1 → XP_020950111.1  rho guanine nucleotide exchange factor 1 isoform X8

      UniProtKB/TrEMBL
      A0A286ZMZ3, A0A4X1SGQ3, A0A8D0JC99, A0A8D1QH12
      Conserved Domains (4) summary
      PHA03418
      Location:328 → 471
      PHA03418; hypothetical E4 protein; Provisional
      smart00325
      Location:481 → 665
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cl02565
      Location:53 → 245
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl17171
      Location:699 → 823
      PH-like; Pleckstrin homology-like domain

    RNA

    1. XR_002344665.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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