tbx-2 T-box protein 2 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: tbx-2
Gene description: T-box protein 2
Primary source: WormBase:WBGene00006543
Locus tag: CELE_F21H11.3
See related: AllianceGenome:WB:WBGene00006543
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables DNA-binding transcription repressor activity; core promoter sequence-specific DNA binding activity; and enzyme binding activity. Involved in several processes, including muscle cell fate specification; olfactory behavior; and pharyngeal muscle development. Located in cytoplasm and nucleus. Is expressed in several structures, including amphid neurons; anal region; head; pharynx; and vulva. Human ortholog(s) of this gene implicated in ulnar-mammary syndrome and vertebral anomalies and variable endocrine and T-cell dysfunction. Orthologous to human TBX2 (T-box transcription factor 2) and TBX3 (T-box transcription factor 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See tbx-2 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 5

Sequence:: Chromosome: III; NC_003281.10 (5130923..5136296, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TBX-2 itself directly represses its own expression in a negative autoregulatory loop.
Title: Caenorhabditis elegans TBX-2 Directly Regulates Its Own Expression in a Negative Autoregulatory Loop.
TBX-2 functions as an UNC-37 dependent transcriptional repressor
Title: Function of the C. elegans T-box factor TBX-2 depends on interaction with the UNC-37/Groucho corepressor.
Reduction of SUMOylation enhances the effect of a tbx-2 hypomorphic mutant on embryonic viability and pharyngeal muscle development, and that repression of a downstream target of TBX-2 depends on SUMOylation.
Title: Function of the C. elegans T-box factor TBX-2 depends on SUMOylation.
These results identify NF-Y as an important regulator of tbx-2 function in vivo.
Title: The NF-Y complex negatively regulates Caenorhabditis elegans tbx-2 expression.
In screens for mutants with abnormal HSN motor neuron development, we identified the T-box protein TBX-2 as being important for both HSN and PHB sensory neuron differentiation.
Title: The T-box gene tbx-2, the homeobox gene egl-5 and the asymmetric cell division gene ham-1 specify neural fate in the HSN/PHB lineage.
TBX-2 and SUMO-conjugating enzymes are necessary for ABa-derived pharyngeal muscle, and we hypothesize that TBX-2 function requires sumoylation.
Title: The T-box factor TBX-2 and the SUMO conjugating enzyme UBC-9 are required for ABa-derived pharyngeal muscle in C. elegans.
Ce-TBX-2, the TBX2/TBX3 transcriptional factor homologue of the nematode Caenorhabditis elegans, is involved in olfactory adaptation
Title: TBX2/TBX3 transcriptional factor homologue controls olfactory adaptation in Caenorhabditis elegans.
The analysis suggests that a positive feedback loop between tbx-2 and pha-4 is required for blastomere-derived precursors to commit to pharyngeal muscle fate.
Title: Role of T-box gene tbx-2 for anterior foregut muscle development in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F21H11.3 (e-PCR)
- UniSTS:313092

F21H11.4 (e-PCR)
- UniSTS:316599

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables core promoter sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell fate specification	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chordate pharyngeal muscle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in developmental process	IEA Inferred from Electronic Annotation more info
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode pharyngeal muscle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
part_of chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription regulator complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: T-box protein 2

NP_001370674.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

5130923..5136296 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001382860.2 → NP_001370674.1 T-box protein 2 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q19691

Conserved Domains (1) summary

cd20188
Location:59 → 243

T-box_TBX2_3-like; DNA-binding domain of T-box transcription factor 2 and 3, and related T-box proteins