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    trr-1 Transcription-associated protein 1 [ Caenorhabditis elegans ]

    Gene ID: 174788, updated on 25-Apr-2024

    Summary

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    Gene symbol
    trr-1
    Gene description
    Transcription-associated protein 1
    Primary source
    WormBase:WBGene00007028
    Locus tag
    CELE_C47D12.1
    See related
    AllianceGenome:WB:WBGene00007028
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein serine/threonine kinase activity. Involved in negative regulation of vulval development; positive regulation of growth rate; and reproduction. Located in condensed chromosome and nucleus. Is expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; P6.p hermaphrodite; and germ line. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 75. Orthologous to human TRRAP (transformation/transcription domain associated protein). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See trr-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    22
    Sequence:
    Chromosome: II; NC_003280.10 (11661569..11675927, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Neprilysin-1 Neighboring gene ncRNA Neighboring gene Dymeclin Neighboring gene Sideroflexin-2;Sidoreflexin Neighboring gene F-box domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The MYST family histone acetyltransferase complex regulates stress resistance and longevity through transcriptional control of DAF-16/FOXO transcription factors. Ikeda T, et al. EMBO Rep, 2017 Oct. PMID 28794203, Free PMC Article
    2. Evolutionary change within a bipotential switch shaped the sperm/oocyte decision in hermaphroditic nematodes. Guo Y, et al. PLoS Genet, 2013. PMID 24098152, Free PMC Article
    3. Methylation and demethylation activities of a C. elegans MLL-like complex attenuate RAS signalling. Fisher K, et al. Dev Biol, 2010 May 1. PMID 20188723
    4. lin-35/Rb and the CoREST ortholog spr-1 coordinately regulate vulval morphogenesis and gonad development in C. elegans. Bender AM, et al. Dev Biol, 2007 Feb 15. PMID 17070797, Free PMC Article
    5. gon-14 functions with class B and class C synthetic multivulva genes to control larval growth in Caenorhabditis elegans. Chesney MA, et al. Genetics, 2006 Feb. PMID 16322520, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of vulval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of growth rate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SAGA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in condensed chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of histone acetyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Transcription-associated protein 1
    NP_001364592.1
    • Confirmed by transcript evidence
    NP_001364646.1
    • Confirmed by transcript evidence
    NP_001364647.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      11661569..11675927 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001377878.3 → NP_001364646.1  Transcription-associated protein 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EEV2, Q5CZ43, Q6A4L2
      Conserved Domains (1) summary
      cd05163
      Location:3678 → 4014
      PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein

    2. NM_001377879.1 → NP_001364592.1  Transcription-associated protein 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EEV2, Q5CZ43, Q6A4L2
      Conserved Domains (1) summary
      cd05163
      Location:3678 → 4017
      PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein

    3. NM_001377877.2 → NP_001364647.1  Transcription-associated protein 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EEV2, Q5CZ43, Q6A4L2
      Conserved Domains (1) summary
      cd05163
      Location:3667 → 4006
      PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    Nucleotide Protein
    Heading Accession and Version

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