Bmf Bcl2 modifying factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bmfprovided by RGD
Official Full Name: Bcl2 modifying factorprovided by RGD
Primary source: RGD:628658
See related: Ensembl:ENSRNOG00000007529 AllianceGenome:RGD:628658
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in several processes, including negative regulation of autophagy; positive regulation of cellular component organization; and regulation of programmed cell death. Predicted to act upstream of or within anoikis; negative regulation of apoptotic signaling pathway; and positive regulation of apoptotic signaling pathway. Located in acrosomal vesicle. Orthologous to human BMF (Bcl2 modifying factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 139.7), Lung (RPKM 131.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q35

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (125953466..125974087, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (105499534..105520159, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (110303515..110324125, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulation of miR-29b-3p alleviates coronary microembolization-induced myocardial injury via regulating BMF and GSK-3beta.
Title: Upregulation of miR-29b-3p alleviates coronary microembolization-induced myocardial injury via regulating BMF and GSK-3β.
miR-874-3p attenuated ischemic injury by negatively regulating BMF and BCL2L13.
Title: Upregulation of miR-874-3p decreases cerebral ischemia/reperfusion injury by directly targeting BMF and BCL2L13.
Reciprocal regulation of BMF and BIRC5 is linked to Eomes overexpression in colorectal cancer.
Title: Reciprocal regulation of BMF and BIRC5 (Survivin) linked to Eomes overexpression in colorectal cancer.
Studies suggest that overexpression of DN-HNF1A induces bioenergetic stress and activation of AMPK, and this in turn mediates the transcriptional activation of BMF, coupling prolonged energy stress to apoptosis activation.
Title: AMP-activated protein kinase mediates apoptosis in response to bioenergetic stress through activation of the pro-apoptotic Bcl-2 homology domain-3-only protein BMF.
Activation of MAPK8 and redistribution of BMF may be integrally involved in the mechanism by which specific germ cells undergo programmed cell death in response to their detachment from Sertoli cells.
Title: Phosphorylation of mitogen-activated protein kinase 8 (MAPK8) is associated with germ cell apoptosis and redistribution of the Bcl2-modifying factor (BMF).
Bmf may well be involved in germ cell apoptosis and/or anoikis in response to decreased intratesticular testosterone concentration.
Title: Testicular expression and distribution of the rat bcl2 modifying factor in response to reduced intratesticular testosterone.

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General gene information

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Markers

D15S214 (e-PCR), detects polymorphism
- UniSTS:52050

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in anoikis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within anoikis	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info
involved_in cellular response to UV	IEA Inferred from Electronic Annotation more info
involved_in cellular response to UV	ISO Inferred from Sequence Orthology more info
involved_in cellular response to starvation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of autophagic cell death	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of autophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of autophagy	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of myosin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: bcl-2-modifying factor

Names: Bcl-2 modifying factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001401791.1 → NP_001388720.1 bcl-2-modifying factor isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q8K589

Related

ENSRNOP00000096398.1, ENSRNOT00000105313.1
NM_001429766.1 → NP_001416695.1 bcl-2-modifying factor isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003
NM_139258.2 → NP_640351.2 bcl-2-modifying factor isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8L2Q4K3, A6HPB4

Related

ENSRNOP00000010381.4, ENSRNOT00000010381.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

125953466..125974087 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006234724.5 → XP_006234786.1 bcl-2-modifying factor isoform X2

UniProtKB/TrEMBL

A6HPB3

Conserved Domains (1) summary

pfam15185
Location:90 → 248

BMF; Bcl-2-modifying factor, apoptosis
XM_008762079.4 → XP_008760301.1 bcl-2-modifying factor isoform X1

Conserved Domains (1) summary

pfam15185
Location:90 → 213

BMF; Bcl-2-modifying factor, apoptosis
XM_063283080.1 → XP_063139150.1 bcl-2-modifying factor isoform X3