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    Aarsd1 alanyl-tRNA synthetase domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 69684, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Aarsd1provided by MGI
    Official Full Name
    alanyl-tRNA synthetase domain containing 1provided by MGI
    Primary source
    MGI:MGI:1916934
    See related
    Ensembl:ENSMUSG00000075528 AllianceGenome:MGI:1916934
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AlaX; AlaXp-II; 1110069E20Rik; 2310044P18Rik
    Summary
    Enables Ser-tRNA(Ala) hydrolase activity. Acts upstream of or within regulation of translational fidelity. Predicted to be located in cytoplasm. Is expressed in submandibular gland primordium. Orthologous to several human genes including PTGES3L-AARSD1 (PTGES3L-AARSD1 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 22.9), liver E14 (RPKM 15.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Aarsd1 in Genome Data Viewer
    Location:
    11 D; 11 64.95 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (101297489..101308422, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (101406663..101417508, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30761 Neighboring gene predicted gene, 51949 Neighboring gene predicted gene, 25475 Neighboring gene prostaglandin E synthase 3 like Neighboring gene microRNA 6929 Neighboring gene STARR-positive B cell enhancer ABC_E596 Neighboring gene RUN domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. p23H implicated as cis/trans regulator of AlaXp-directed editing for mammalian cell homeostasis. Nawaz MH, et al. Proc Natl Acad Sci U S A, 2011 Feb 15. PMID 21285375, Free PMC Article
    2. A Remodeled Hsp90 Molecular Chaperone Ensemble with the Novel Cochaperone Aarsd1 Is Required for Muscle Differentiation. Echeverría PC, et al. Mol Cell Biol, 2016 Apr. PMID 26884463, Free PMC Article
    3. Distinct domains of tRNA synthetase recognize the same base pair. Beebe K, et al. Nature, 2008 Jan 3. PMID 18172502
    4. Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. Quina LA, et al. J Neurosci, 2009 Nov 11. PMID 19906978, Free PMC Article
    5. Bioinformatics and cellular signaling. Papin J, et al. Curr Opin Biotechnol, 2004 Feb. PMID 15102471

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Artificially maintaining Hsp90alpha or knocking down Aarsd1L expression interferes with the differentiation of C2C12 myotubes.
      Title: A Remodeled Hsp90 Molecular Chaperone Ensemble with the Novel Cochaperone Aarsd1 Is Required for Muscle Differentiation.
    2. Deacylates mischarged tRNA(Ala) (AlaXp activity)
      Title: Distinct domains of tRNA synthetase recognize the same base pair.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Ser-tRNA(Ala) hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Ser-tRNA(Ala) hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alanine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA editing activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in alanyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of translational fidelity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of translational fidelity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alanyl-tRNA editing protein Aarsd1
    Names
    alanyl-tRNA deacylase alaX
    alanyl-tRNA synthetase domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144829.1 → NP_659078.1  alanyl-tRNA editing protein Aarsd1

      See identical proteins and their annotated locations for NP_659078.1

      Status: PROVISIONAL

      Source sequence(s)
      BC005711
      Consensus CDS
      CCDS25467.1
      UniProtKB/Swiss-Prot
      Q3THG9, Q3UWH8, Q8BVJ6, Q99JS9
      Related
      ENSMUSP00000067912.9, ENSMUST00000070395.9
      Conserved Domains (2) summary
      COG2872
      Location:8 → 248
      AlaX; Ser-tRNA(Ala) deacylase AlaX (editing enzyme) [Translation, ribosomal structure and biogenesis]
      cl08469
      Location:43 → 231
      tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      101297489..101308422 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534121.4 → XP_006534184.1  alanyl-tRNA editing protein Aarsd1 isoform X2

      Conserved Domains (1) summary
      PRK13902
      Location:29 → 241
      alaS; alanyl-tRNA synthetase; Provisional

    2. XM_036156964.1 → XP_036012857.1  alanyl-tRNA editing protein Aarsd1 isoform X1

      Conserved Domains (2) summary
      COG0013
      Location:1 → 303
      AlaS; Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      COG2872
      Location:1 → 143
      AlaX; Ser-tRNA(Ala) deacylase AlaX (editing enzyme) [Translation, ribosomal structure and biogenesis]

    3. XM_036156965.1 → XP_036012858.1  alanyl-tRNA editing protein Aarsd1 isoform X2

      Conserved Domains (1) summary
      PRK13902
      Location:29 → 241
      alaS; alanyl-tRNA synthetase; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3THG9.2 GenPept UniProtKB/Swiss-Prot:Q3THG9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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