Psmb11 proteasome (prosome, macropain) subunit, beta type, 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Psmb11provided by MGI
Official Full Name: proteasome (prosome, macropain) subunit, beta type, 11provided by MGI
Primary source: MGI:MGI:1921152
See related: Ensembl:ENSMUSG00000072423 AllianceGenome:MGI:1921152
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: beta5t; 5830406J20Rik
Summary: Predicted to enable endopeptidase activity. Acts upstream of or within CD8-positive, alpha-beta T cell differentiation and T cell differentiation in thymus. Part of proteasome core complex. Is expressed in thymus cortex epithelium. Orthologous to human PSMB11 (proteasome subunit beta 11). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 14 C2; 14 27.87 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (54862767..54867013)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (54625310..54629556)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We conclude that PSMB11 has pervasive effects on both CD4 and CD8 thymocytes via regulation of gene expression in cortical thymic epithelial cells.
Title: PSMB11 Orchestrates the Development of CD4 and CD8 Thymocytes via Regulation of Gene Expression in Cortical Thymic Epithelial Cells.
Study report the identification of a highly conserved Foxn1-binding sequence that is located proximal to the beta5t-coding sequence in the mouse genome. This cis-regulatory element is indeed essential for the optimal expression of beta5t in cortical thymic epithelial cells and the optimal production of CD8+ T cells.
Title: Foxn1-β5t transcriptional axis controls CD8(+) T-cell production in the thymus.
beta5t-containing thymoproteasomes contribute to the positive selection of CD8+ T cells by preferentially producing low-affinity TCR ligand peptides.
Title: Thymoproteasomes produce unique peptide motifs for positive selection of CD8(+) T cells.
The current data showed that impaired proteasomal function causes photoreceptor degeneration.
Title: Decreased proteasomal activity causes photoreceptor degeneration in mice.
Results indicate that the majority of thymic medullary epithelial cells (mTECs) are derived from beta5t-expressing progenitor cells.
Title: Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cells.
Thymoproteasome subunit-beta5T generates peptide-MHC complexes specialized for positive selection.
Title: Thymoproteasome subunit-β5T generates peptide-MHC complexes specialized for positive selection.
results indicate that beta5t expression in thymic cortical epithelial cells is dependent on Foxn1 but independent of thymocyte crosstalk or thymic medulla formation
Title: Ontogeny of thymic cortical epithelial cells expressing the thymoproteasome subunit β5t.
results suggest a key role for proteasome subunit beta5t in generating the MHC class I-restricted CD8(+) T cell repertoire during thymic selection
Title: Regulation of CD8+ T cell development by thymus-specific proteasomes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Spontaneous (1) 1 citation
Targeted (7) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables threonine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within CD8-positive, alpha-beta T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within T cell differentiation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	ISO Inferred from Sequence Orthology more info	PubMed
involved_in proteolysis involved in protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome core complex, beta-subunit complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: proteasome subunit beta type-11

Names: proteasome beta 11 subunit; proteasome subunit beta-5t; proteasome subunit beta5t

NP_780413.1

EC 3.4.25.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175204.4 → NP_780413.1 proteasome subunit beta type-11

See identical proteins and their annotated locations for NP_780413.1

Status: VALIDATED

Source sequence(s)

AK162727, CT009512

Consensus CDS

CCDS49491.1

UniProtKB/Swiss-Prot

Q149K8, Q8BG41

Related

ENSMUSP00000132140.2, ENSMUST00000097177.5

Conserved Domains (2) summary

TIGR03690
Location:48 → 253

20S_bact_beta; proteasome, beta subunit, bacterial type

cd03761
Location:50 → 237

proteasome_beta_type_5; proteasome beta type-5 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...