Cdc6 cell division cycle 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdc6provided by MGI
Official Full Name: cell division cycle 6provided by MGI
Primary source: MGI:MGI:1345150
See related: Ensembl:ENSMUSG00000017499 AllianceGenome:MGI:1345150
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CDC18L; p62(cdc6)
Summary: Enables chromatin binding activity. Predicted to be involved in several processes, including positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of fibroblast proliferation; and regulation of cell cycle process. Predicted to act upstream of or within DNA replication and cell division. Located in cytoplasm and spindle. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 5. Orthologous to human CDC6 (cell division cycle 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E14 (RPKM 13.4), liver E14.5 (RPKM 11.7) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 62.74 cM; 11 D

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (98798627..98814768)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (98907709..98923942)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Novel Role of Prereplication Complex Component Cell Division Cycle 6 in Retinal Neovascularization.
Title: Novel Role of Prereplication Complex Component Cell Division Cycle 6 in Retinal Neovascularization.
CDC6 regulates both G2/M transition and metaphase-to-anaphase transition during the first meiosis of mouse oocytes.
Title: CDC6 regulates both G2/M transition and metaphase-to-anaphase transition during the first meiosis of mouse oocytes.
Dele and Cdc6 G-quadruplex formation is significant in the transcriptional regulation. Dele and Cdc6 G-quadruplex DNA alone possess enhancer and promotor function.
Title: Identification of G-quadruplex structures that possess transcriptional regulating functions in the Dele and Cdc6 CpG islands.
CDK1 activation proceeds with concomitant inhibition by CDC6, which tunes the timing of the M-phase entry during the embryonic cell cycle
Title: CDC6 controls dynamics of the first embryonic M-phase entry and progression via CDK1 inhibition.
Cdc6 continued to block apoptosome assembly induced by a non-cytochrome c or some other mechanism, suppressing seemingly unintended apoptosis when promoting cell proliferation
Title: Cdc6 protein obstructs apoptosome assembly and consequent cell death by forming stable complexes with activated Apaf-1 molecules.
show that MyoD can occupy an E-box within the promoter of Cdc6 and that this association, along with E2F3a, is required for its activity.
Title: Activation of Cdc6 by MyoD is associated with the expansion of quiescent myogenic satellite cells.
hCdt1 and hCdc6 expression promote malignant behavior
Title: Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior.
CDC6 is essential for spindle formation in mouse oocytes
Title: CDC6 requirement for spindle formation during maturation of mouse oocytes.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables DNA replication origin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA replication initiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in mitotic DNA replication checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of chromosome segregation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic metaphase/anaphase transition	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in spindle	IDA Inferred from Direct Assay more info	PubMed
located_in spindle midzone	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cell division control protein 6 homolog

Names: CDC6-related protein; cell division cycle 6 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025779.2 → NP_001020950.1 cell division control protein 6 homolog isoform b

See identical proteins and their annotated locations for NP_001020950.1

Status: VALIDATED

Source sequence(s)

AL591067, BC052434

Consensus CDS

CCDS25368.1

UniProtKB/Swiss-Prot

O89033, Q3TMD0, Q8C3S5, Q9CZT0

Related

ENSMUSP00000090382.7, ENSMUST00000092706.13

Conserved Domains (3) summary

smart01074
Location:467 → 547

Cdc6_C; CDC6, C terminal

COG1474
Location:170 → 547

CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]

pfam13191
Location:173 → 314

AAA_16; AAA ATPase domain
NM_001362735.1 → NP_001349664.1 cell division control protein 6 homolog isoform c

Status: VALIDATED

Source sequence(s)

AL591067

Conserved Domains (1) summary

COG1474
Location:170 → 546

CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
NM_011799.2 → NP_035929.1 cell division control protein 6 homolog isoform a

See identical proteins and their annotated locations for NP_035929.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a).

Source sequence(s)

AJ223087, AL591067

Consensus CDS

CCDS25367.1

UniProtKB/TrEMBL

A0A0R4J145

Related

ENSMUSP00000091469.3, ENSMUST00000093937.3

Conserved Domains (3) summary

smart01074
Location:494 → 574

Cdc6_C; CDC6, C terminal

COG1474
Location:197 → 574

CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]

pfam13191
Location:200 → 341

AAA_16; AAA ATPase domain