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    Sp2 Sp2 transcription factor [ Mus musculus (house mouse) ]

    Gene ID: 78912, updated on 12-May-2024

    Summary

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    Official Symbol
    Sp2provided by MGI
    Official Full Name
    Sp2 transcription factorprovided by MGI
    Primary source
    MGI:MGI:1926162
    See related
    Ensembl:ENSMUSG00000018678 AllianceGenome:MGI:1926162
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0048; 4930480I16Rik
    Summary
    This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. The protein can act as a transcriptional activator or repressor, depending on the promoter and cell type. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thymus adult (RPKM 15.0), spleen adult (RPKM 11.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 D; 11 60.17 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (96844158..96873785, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (96953332..96982959, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11525 Neighboring gene STARR-seq mESC enhancer starr_30572 Neighboring gene proline rich 15-like Neighboring gene RIKEN cDNA D030028A08 gene Neighboring gene STARR-positive B cell enhancer ABC_E2367 Neighboring gene pyridoxine 5'-phosphate oxidase Neighboring gene STARR-positive B cell enhancer ABC_E11488 Neighboring gene STARR-positive B cell enhancer ABC_E20 Neighboring gene STARR-seq mESC enhancer starr_30576 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:96849306-96849459 Neighboring gene predicted gene, 51916 Neighboring gene STARR-positive B cell enhancer ABC_E1429 Neighboring gene STARR-seq mESC enhancer starr_30578 Neighboring gene trans-acting transcription factor 6 Neighboring gene predicted gene 11532

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genome-wide localization and expression profiling establish Sp2 as a sequence-specific transcription factor regulating vitally important genes. Terrados G, et al. Nucleic Acids Res, 2012 Sep. PMID 22684502, Free PMC Article
    2. Overexpression of transcription factor sp2 inhibits epidermal differentiation and increases susceptibility to wound- and carcinogen-induced tumorigenesis. Kim TH, et al. Cancer Res, 2010 Nov 1. PMID 20959487, Free PMC Article
    3. Transcription of mouse Sp2 yields alternatively spliced and sub-genomic mRNAs in a tissue- and cell-type-specific fashion. Yin H, et al. Biochim Biophys Acta, 2010 Jul. PMID 20353838, Free PMC Article
    4. Regulation of inhibitor of differentiation gene 3 (Id3) expression by Sp2-motif binding factor in myogenic C2C12 cells: downregulation of DNA binding activity following skeletal muscle differentiation. Wu J, et al. Biochim Biophys Acta, 2005 Oct 15. PMID 16216350
    5. Sp2 DNA binding activity and trans-activation are negatively regulated in mammalian cells. Moorefield KS, et al. J Biol Chem, 2004 Apr 2. PMID 14726517

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. there is a stage-specific requirement for Sp2 in neural stem and progenitor cells in the mouse cortex
      Title: Sp2 regulates late neurogenic but not early expansive divisions of neural stem cells underlying population growth in the mouse cortex.
    2. a mechanism by which the DNA binding-independent activity of Sp2 potentiates genomic loading of Pbx1:Prep1 and Nf-y to composite motifs present in many promoters of highly expressed genes
      Title: Transcription factor Sp2 potentiates binding of the TALE homeoproteins Pbx1:Prep1 and the histone-fold domain protein Nf-y to composite genomic sites.
    3. SP2 as important factor responsible for higher Cd14 expression and reduced IBD susceptibility mediated by the C3Bir allele.
      Title: Transcription Factor SP2 Enhanced the Expression of Cd14 in Colitis-Susceptible C3H/HeJBir.
    4. Our results unveil strikingly different recruitment mechanisms of Sp1/Sp2/Sp3 transcription factor members uncovering an unexpected layer of complexity in their binding to chromatin in vivo.
      Title: Zinc finger independent genome-wide binding of Sp2 potentiates recruitment of histone-fold protein Nf-y distinguishing it from Sp1 and Sp3.
    5. Sp2 deletion disrupts neurogenesis in the embryonic and postnatal brain.
      Title: Neural development is dependent on the function of specificity protein 2 in cell cycle progression.
    6. Specificity protein 2 (Sp2) is essential for mouse development and autonomous proliferation of mouse embryonic fibroblasts
      Title: Specificity protein 2 (Sp2) is essential for mouse development and autonomous proliferation of mouse embryonic fibroblasts.
    7. Overexpression of transcription factor sp2 inhibits epidermal differentiation and increases susceptibility to wound- and carcinogen-induced tumorigenesis.
      Title: Overexpression of transcription factor sp2 inhibits epidermal differentiation and increases susceptibility to wound- and carcinogen-induced tumorigenesis.
    8. mouse Sp2 transcription yields alternatively spliced and sub-genomic mRNAs in a tissue- and cell-type-specific fashion
      Title: Transcription of mouse Sp2 yields alternatively spliced and sub-genomic mRNAs in a tissue- and cell-type-specific fashion.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within circulatory system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryonic organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor Sp2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080964.2 → NP_001074433.1  transcription factor Sp2 isoform 2

      See identical proteins and their annotated locations for NP_001074433.1

      Status: VALIDATED

      Source sequence(s)
      AA267604, AL596384, BC086457, BP765918
      UniProtKB/Swiss-Prot
      Q6A0E1, Q9D2H6
      UniProtKB/TrEMBL
      D1MAF3
      Conserved Domains (3) summary
      sd00017
      Location:529 → 548
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:584 → 606
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:570 → 593
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001363225.1 → NP_001350154.1  transcription factor Sp2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK019649, AL596384
      Consensus CDS
      CCDS88237.1
      UniProtKB/TrEMBL
      D1MAF3, Q3UTN3, Q8BNQ4
      Related
      ENSMUSP00000051403.7, ENSMUST00000062652.7
      Conserved Domains (4) summary
      COG5048
      Location:443 → 581
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:524 → 543
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:579 → 601
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:565 → 588
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001363226.1 → NP_001350155.1  transcription factor Sp2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK080877, AL596384
      Consensus CDS
      CCDS88237.1
      UniProtKB/TrEMBL
      D1MAF3, Q3UTN3, Q8BNQ4
      Related
      ENSMUSP00000103249.2, ENSMUST00000107623.8
      Conserved Domains (4) summary
      COG5048
      Location:443 → 581
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:524 → 543
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:579 → 601
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:565 → 588
      zf-H2C2_2; Zinc-finger double domain

    4. NM_030220.4 → NP_084496.2  transcription factor Sp2 isoform 1

      See identical proteins and their annotated locations for NP_084496.2

      Status: VALIDATED

      Source sequence(s)
      AA267604, AK078246, AL596384, BB848633, BC086457, BP765918
      Consensus CDS
      CCDS36291.1
      UniProtKB/TrEMBL
      Q3UTN3, Q8C5J0
      Related
      ENSMUSP00000103250.3, ENSMUST00000107624.8
      Conserved Domains (3) summary
      sd00017
      Location:530 → 549
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:585 → 607
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:571 → 594
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      96844158..96873785 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534518.5 → XP_006534581.1  transcription factor Sp2 isoform X1

      See identical proteins and their annotated locations for XP_006534581.1

      UniProtKB/TrEMBL
      D1MAF3, Q3UTN3, Q8BNQ4
      Conserved Domains (4) summary
      COG5048
      Location:443 → 581
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:524 → 543
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:579 → 601
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:565 → 588
      zf-H2C2_2; Zinc-finger double domain

    2. XM_006534519.4 → XP_006534582.1  transcription factor Sp2 isoform X1

      See identical proteins and their annotated locations for XP_006534582.1

      UniProtKB/TrEMBL
      D1MAF3, Q3UTN3, Q8BNQ4
      Conserved Domains (4) summary
      COG5048
      Location:443 → 581
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:524 → 543
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:579 → 601
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:565 → 588
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D2H6.2 GenPept UniProtKB/Swiss-Prot:Q9D2H6

    Gene LinkOut

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