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    Ube2e3 ubiquitin-conjugating enzyme E2E 3 [ Mus musculus (house mouse) ]

    Gene ID: 22193, updated on 12-May-2024

    Summary

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    Official Symbol
    Ube2e3provided by MGI
    Official Full Name
    ubiquitin-conjugating enzyme E2E 3provided by MGI
    Primary source
    MGI:MGI:107412
    See related
    Ensembl:ENSMUSG00000027011 AllianceGenome:MGI:107412
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ubce4; ubcM2
    Summary
    Enables ubiquitin conjugating enzyme activity. Predicted to be involved in protein K11-linked ubiquitination; protein K48-linked ubiquitination; and protein K63-linked ubiquitination. Predicted to act upstream of or within regulation of growth. Located in nucleus. Orthologous to human UBE2E3 (ubiquitin conjugating enzyme E2 E3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 33.4), CNS E14 (RPKM 32.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ube2e3 in Genome Data Viewer
    Location:
    2 C3; 2 47.15 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (78698696..78759132)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (78868236..78928786)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39865 Neighboring gene predicted gene 17014 Neighboring gene STARR-positive B cell enhancer ABC_E4470 Neighboring gene STARR-positive B cell enhancer ABC_E10119 Neighboring gene STARR-positive B cell enhancer ABC_E1246 Neighboring gene predicted gene, 37004 Neighboring gene STARR-positive B cell enhancer ABC_E10120 Neighboring gene STARR-positive B cell enhancer ABC_E4471 Neighboring gene STARR-positive B cell enhancer ABC_E5937 Neighboring gene predicted gene, 35748

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mice lacking the UBC4-testis gene have a delay in postnatal testis development but normal spermatogenesis and fertility. Bedard N, et al. Mol Cell Biol, 2005 Aug. PMID 16024774, Free PMC Article
    2. Isolation of growth suppressors from a cDNA expression library. Pestov DG, et al. Oncogene, 1998 Dec 17. PMID 9872334
    3. Provirus integration into a gene encoding a ubiquitin-conjugating enzyme results in a placental defect and embryonic lethality. Harbers K, et al. Proc Natl Acad Sci U S A, 1996 Oct 29. PMID 8901595, Free PMC Article
    4. Participation of the ubiquitin-conjugating enzyme UBE2E3 in Nedd4-2-dependent regulation of the epithelial Na+ channel. Debonneville C, et al. Mol Cell Biol, 2004 Mar. PMID 14993279, Free PMC Article
    5. RNF220, an E3 ubiquitin ligase that targets Sin3B for ubiquitination. Kong Q, et al. Biochem Biophys Res Commun, 2010 Mar 19. PMID 20170641

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. UBC4-testis isoform plays a role in early maturation of the testis
      Title: Mice lacking the UBC4-testis gene have a delay in postnatal testis development but normal spermatogenesis and fertility.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein K11-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K63-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquitin-conjugating enzyme E2 E3
    Names
    E2 ubiquitin-conjugating enzyme E3
    ubiquitin carrier protein E3
    ubiquitin-conjugating enzyme 4
    ubiquitin-conjugating enzyme E2-23 kDa
    ubiquitin-conjugating enzyme E2E 3, UBC4/5 homolog
    ubiquitin-protein ligase E3
    NP_001343324.1
    NP_001408107.1
    NP_001408108.1
    NP_001408109.1
    NP_001408110.1
    NP_001408111.1
    NP_001408112.1
    NP_001408113.1
    NP_001408114.1
    NP_001408115.1
    NP_033480.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356395.2 → NP_001343324.1  ubiquitin-conjugating enzyme E2 E3 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 5-9 all encode the same isoform (a).
      Source sequence(s)
      AL772181, AL928604
      Consensus CDS
      CCDS16167.1
      UniProtKB/Swiss-Prot
      O09180, P52483, Q3TI00, Q91X63
      Related
      ENSMUSP00000113463.2, ENSMUST00000121433.2
      Conserved Domains (1) summary
      pfam00179
      Location:65 → 202
      UQ_con; Ubiquitin-conjugating enzyme

    2. NM_001421178.1 → NP_001408107.1  ubiquitin-conjugating enzyme E2 E3 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL772181, AL928604
      UniProtKB/Swiss-Prot
      O09180, P52483, Q3TI00, Q91X63

    3. NM_001421179.1 → NP_001408108.1  ubiquitin-conjugating enzyme E2 E3 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL772181, AL928604
      UniProtKB/Swiss-Prot
      O09180, P52483, Q3TI00, Q91X63

    4. NM_001421180.1 → NP_001408109.1  ubiquitin-conjugating enzyme E2 E3 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL772181, AL928604
      UniProtKB/Swiss-Prot
      O09180, P52483, Q3TI00, Q91X63

    5. NM_001421181.1 → NP_001408110.1  ubiquitin-conjugating enzyme E2 E3 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL772181, AL928604
      UniProtKB/Swiss-Prot
      O09180, P52483, Q3TI00, Q91X63

    6. NM_001421182.1 → NP_001408111.1  ubiquitin-conjugating enzyme E2 E3 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL772181, AL928604
      UniProtKB/Swiss-Prot
      O09180, P52483, Q3TI00, Q91X63

    7. NM_001421183.1 → NP_001408112.1  ubiquitin-conjugating enzyme E2 E3 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL772181, AL928604

    8. NM_001421184.1 → NP_001408113.1  ubiquitin-conjugating enzyme E2 E3 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL772181, AL928604

    9. NM_001421185.1 → NP_001408114.1  ubiquitin-conjugating enzyme E2 E3 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL772181, AL928604

    10. NM_001421186.1 → NP_001408115.1  ubiquitin-conjugating enzyme E2 E3 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL928604

    11. NM_009454.3 → NP_033480.1  ubiquitin-conjugating enzyme E2 E3 isoform a

      See identical proteins and their annotated locations for NP_033480.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, and 5-9 all encode the same isoform (a).
      Source sequence(s)
      AL772181, AL928604
      Consensus CDS
      CCDS16167.1
      UniProtKB/Swiss-Prot
      O09180, P52483, Q3TI00, Q91X63
      Related
      ENSMUSP00000028398.8, ENSMUST00000028398.14
      Conserved Domains (1) summary
      pfam00179
      Location:65 → 202
      UQ_con; Ubiquitin-conjugating enzyme

    RNA

    1. NR_151457.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' and 3' ends compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL772181, AL928604

    2. NR_151458.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' and 3' ends compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL772181, AL928604

    3. NR_185265.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL772181, AL928604

    4. NR_185266.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL772181, AL928604

    5. NR_185267.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL772181

    6. NR_185268.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL772181

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      78698696..78759132
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52483.2 GenPept UniProtKB/Swiss-Prot:P52483

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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