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    Slc7a3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 [ Mus musculus (house mouse) ]

    Gene ID: 11989, updated on 9-May-2024

    Summary

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    Official Symbol
    Slc7a3provided by MGI
    Official Full Name
    solute carrier family 7 (cationic amino acid transporter, y+ system), member 3provided by MGI
    Primary source
    MGI:MGI:1100521
    See related
    Ensembl:ENSMUSG00000031297 AllianceGenome:MGI:1100521
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CAT3; Atrc3; CAT-3; SLC7A1; SLC7A2
    Summary
    The protein encoded by this gene is a member of the system y+ cationic amino acid transporter family. Proteins of this family allow uptake of arginine from extracellular media. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
    Expression
    Broad expression in CNS E18 (RPKM 4.8), limb E14.5 (RPKM 1.7) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc7a3 in Genome Data Viewer
    Location:
    X C3- D; X 43.72 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (100122752..100134058, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (101079146..101090452, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene high mobility group protein B1-like Neighboring gene predicted gene 3820 Neighboring gene STARR-seq mESC enhancer starr_47640 Neighboring gene sorting nexin 12 Neighboring gene predicted gene, 24061 Neighboring gene predicted gene, 22472

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. p53 Promotes Cancer Cell Adaptation to Glutamine Deprivation by Upregulating Slc7a3 to Increase Arginine Uptake. Lowman XH, et al. Cell Rep, 2019 Mar 12. PMID 30865893, Free PMC Article
    2. Increased Cat3-mediated cationic amino acid transport functionally compensates in Cat1 knockout cell lines. Nicholson B, et al. J Biol Chem, 1998 Jun 12. PMID 9614060
    3. Extracellular arginine is required but the arginine transporter CAT3 (Slc7a3) is dispensable for mouse normal and malignant hematopoiesis. Yan Y, et al. Sci Rep, 2022 Dec 17. PMID 36528691, Free PMC Article
    4. A new member of the cationic amino acid transporter family is preferentially expressed in adult mouse brain. Ito K, et al. J Biol Chem, 1997 Oct 17. PMID 9334265
    5. Y+ and y+ L arginine transporters in neuronal cells expressing tyrosine hydroxylase. Bae SY, et al. Biochim Biophys Acta, 2005 Aug 15. PMID 16085056

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Extracellular arginine is required but the arginine transporter CAT3 (Slc7a3) is dispensable for mouse normal and malignant hematopoiesis.
      Title: Extracellular arginine is required but the arginine transporter CAT3 (Slc7a3) is dispensable for mouse normal and malignant hematopoiesis.
    2. Slc7a3 expression is significantly induced by p53 upon glutamine deprivation.
      Title: p53 Promotes Cancer Cell Adaptation to Glutamine Deprivation by Upregulating Slc7a3 to Increase Arginine Uptake.
    3. knockdown impaired AMPK-PPAR-alpha signaling and resulted in lipid accumulation under fasting
      Title: Genetic ablation of solute carrier family 7a3a leads to hepatic steatosis in zebrafish during fasting.
    4. In a neuronal cell model, y+,L and y+ transport systems are the predominant form of arginine uptake mechanisms and the transport of arginine is altered by membrane potential and redox factors.
      Title: Y+ and y+ L arginine transporters in neuronal cells expressing tyrosine hydroxylase.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-arginine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-arginine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-arginine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-lysine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-lysine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-lysine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-ornithine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-ornithine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables basic amino acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables basic amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-arginine import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-arginine import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within L-arginine transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in L-arginine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-lysine import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-lysine transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in L-ornithine import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-ornithine transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within basic amino acid transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lysine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ornithine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cationic amino acid transporter 3
    Names
    amino acid transporter, cationic 3
    cationic amino acid transporter y+
    solute carrier family 7 member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301840.1 → NP_001288769.1  cationic amino acid transporter 3

      See identical proteins and their annotated locations for NP_001288769.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK077593, AK141558
      Consensus CDS
      CCDS30309.1
      UniProtKB/Swiss-Prot
      B1AVE2, P70423
      UniProtKB/TrEMBL
      Q3TMH5
      Related
      ENSMUSP00000073582.5, ENSMUST00000073927.5
      Conserved Domains (1) summary
      TIGR00906
      Location:4 → 588
      2A0303; cationic amino acid transport permease

    2. NM_007515.3 → NP_031541.1  cationic amino acid transporter 3

      See identical proteins and their annotated locations for NP_031541.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK077593, AK141558, CD540305
      Consensus CDS
      CCDS30309.1
      UniProtKB/Swiss-Prot
      B1AVE2, P70423
      UniProtKB/TrEMBL
      Q3TMH5
      Related
      ENSMUSP00000098914.2, ENSMUST00000101362.8
      Conserved Domains (1) summary
      TIGR00906
      Location:4 → 588
      2A0303; cationic amino acid transport permease

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      100122752..100134058 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247513.2 → XP_011245815.1  cationic amino acid transporter 3 isoform X1

      See identical proteins and their annotated locations for XP_011245815.1

      UniProtKB/Swiss-Prot
      B1AVE2, P70423
      UniProtKB/TrEMBL
      Q3TMH5
      Conserved Domains (1) summary
      TIGR00906
      Location:4 → 588
      2A0303; cationic amino acid transport permease

    2. XM_006527753.3 → XP_006527816.1  cationic amino acid transporter 3 isoform X1

      See identical proteins and their annotated locations for XP_006527816.1

      UniProtKB/Swiss-Prot
      B1AVE2, P70423
      UniProtKB/TrEMBL
      Q3TMH5
      Related
      ENSMUSP00000109339.2, ENSMUST00000113710.8
      Conserved Domains (1) summary
      TIGR00906
      Location:4 → 588
      2A0303; cationic amino acid transport permease

    3. XM_036161792.1 → XP_036017685.1  cationic amino acid transporter 3 isoform X1

      UniProtKB/Swiss-Prot
      B1AVE2, P70423
      UniProtKB/TrEMBL
      Q3TMH5
      Conserved Domains (1) summary
      TIGR00906
      Location:4 → 588
      2A0303; cationic amino acid transport permease

    4. XM_036161793.1 → XP_036017686.1  cationic amino acid transporter 3 isoform X1

      UniProtKB/Swiss-Prot
      B1AVE2, P70423
      UniProtKB/TrEMBL
      Q3TMH5
      Conserved Domains (1) summary
      TIGR00906
      Location:4 → 588
      2A0303; cationic amino acid transport permease

    5. XM_036161791.1 → XP_036017684.1  cationic amino acid transporter 3 isoform X1

      UniProtKB/Swiss-Prot
      B1AVE2, P70423
      UniProtKB/TrEMBL
      Q3TMH5
      Conserved Domains (1) summary
      TIGR00906
      Location:4 → 588
      2A0303; cationic amino acid transport permease
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70423.1 GenPept UniProtKB/Swiss-Prot:P70423

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