TST thiosulfate sulfurtransferase [Homo sapiens (human)] - Gene

Summary

Official Symbol: TSTprovided by HGNC
Official Full Name: thiosulfate sulfurtransferaseprovided by HGNC
Primary source: HGNC:HGNC:12388
See related: Ensembl:ENSG00000128311 MIM:180370; AllianceGenome:HGNC:12388
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RDS
Summary: This is one of two neighboring genes encoding similar proteins that each contain two rhodanese domains. The encoded protein is localized to the mitochondria and catalyzes the conversion of thiosulfate and cyanide to thiocyanate and sulfite. In addition, the protein interacts with 5S ribosomal RNA and facilitates its import into the mitochondria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Expression: Broad expression in colon (RPKM 83.2), liver (RPKM 73.2) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 22q12.3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	22	NC_000022.11 (37010859..37020183, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	22	NC_060946.1 (37470450..37479782, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	22	NC_000022.10 (37406900..37416224, complement)

Chromosome 22 - NC_000022.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Unraveling the role of thiosulfate sulfurtransferase in metabolic diseases.
Title: Unraveling the role of thiosulfate sulfurtransferase in metabolic diseases.
TST mRNA expression in adipose tissue correlated positively with insulin sensitivity in adipose tissue and negatively with fat mass.
Title: Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness.
show that polymorphic variations that are distant from the active site differentially modulate the sulfurtransferase activity of human rhodanese to cyanide versus sulfite
Title: Polymorphic Variants of Human Rhodanese Exhibit Differences in Thermal Stability and Sulfur Transfer Kinetics.
Loss of Thiosulfate Sulfurtransferase is associated with decreased mucosal sulfide detoxification capacity in patients with Crohn's disease
Title: Decreased mucosal sulfide detoxification capacity in patients with Crohn's disease.
Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
silencing of the rhodanese gene caused not only a proportional decrease of 5 S rRNA import but also a general inhibition of mitochondrial translation, indicating the functional importance of the imported 5 S rRNA inside the organelle.
Title: Mitochondrial enzyme rhodanese is essential for 5 S ribosomal RNA import into human mitochondria.
Proteomics was used to study colonic epithelial aging, for differential proteins in the human normal colonic epithelial tissues from young and old people. Rack1, EF-Tu and Rhodanese, three validated differential proteins, were further investigated.
Title: Identification of Rack1, EF-Tu and Rhodanese as aging-related proteins in human colonic epithelium by proteomic analysis.
The USP8 recognition domain of NRDP1 has a novel protein fold that interacts with a conserved peptide loop of the rhodanese domain.
Title: Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8).

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G65336 (e-PCR)
- UniSTS:166469

D22S317E (e-PCR)
- UniSTS:41611

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 3-mercaptopyruvate sulfurtransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 5S rRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables thiosulfate sulfurtransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thiosulfate sulfurtransferase activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
involved_in cyanate catabolic process	TAS Traceable Author Statement more info	PubMed
involved_in epithelial cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in rRNA import into mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rRNA transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sulfur amino acid catabolic process	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
located_in extracellular space	HDA more info	PubMed
located_in mitochondrial matrix	TAS Traceable Author Statement more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: thiosulfate sulfurtransferase

Names: epididymis secretory sperm binding protein; thiosulfate sulfurtransferase (rhodanese)

NP_001257412.1

EC 2.8.1.1

NP_003303.2

EC 2.8.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_027994.1 RefSeqGene

Range

5004..13586

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001270483.1 → NP_001257412.1 thiosulfate sulfurtransferase

See identical proteins and their annotated locations for NP_001257412.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AW070418, BQ231617, Z73420

Consensus CDS

CCDS13938.1

UniProtKB/Swiss-Prot

B3KRM1, Q16762, Q6IB06

UniProtKB/TrEMBL

A0A384NKQ2, Q53EW8

Related

ENSP00000478739.1, ENST00000622841.1

Conserved Domains (1) summary

COG2897
Location:10 → 279

SseA; 3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion transport and metabolism]
NM_003312.6 → NP_003303.2 thiosulfate sulfurtransferase

See identical proteins and their annotated locations for NP_003303.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AI869664, BC010148

Consensus CDS

CCDS13938.1

UniProtKB/Swiss-Prot

B3KRM1, Q16762, Q6IB06

UniProtKB/TrEMBL

A0A384NKQ2, Q53EW8

Related

ENSP00000249042.3, ENST00000249042.8

Conserved Domains (1) summary

COG2897
Location:10 → 279

SseA; 3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion transport and metabolism]