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    Meiob meiosis specific with OB domains [ Mus musculus (house mouse) ]

    Gene ID: 75178, updated on 12-May-2024

    Summary

    Official Symbol
    Meiobprovided by MGI
    Official Full Name
    meiosis specific with OB domainsprovided by MGI
    Primary source
    MGI:MGI:1922428
    See related
    Ensembl:ENSMUSG00000024155 AllianceGenome:MGI:1922428
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MLZ-675; 4930528F23Rik
    Summary
    Enables chromatin binding activity; single-stranded DNA 3'-5' exodeoxyribonuclease activity; and single-stranded DNA binding activity. Involved in double-strand break repair via homologous recombination; fertilization; and meiosis I. Acts upstream of or within male meiotic nuclear division. Located in cytoplasm. Is expressed in genitourinary system. Human ortholog(s) of this gene implicated in spermatogenic failure 22. Orthologous to human MEIOB (meiosis specific with OB-fold). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 1.7), liver E14 (RPKM 0.5) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Meiob in Genome Data Viewer
    Location:
    17 A3.3; 17 12.53 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25023275..25058762)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24804301..24839788)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E265 Neighboring gene methionine sulfoxide reductase B1 Neighboring gene heparan sulfate (glucosamine) 3-O-sulfotransferase 6 Neighboring gene STARR-positive B cell enhancer ABC_E486 Neighboring gene hydroxyacyl glutathione hydrolase Neighboring gene fumarylacetoacetate hydrolase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_42099 Neighboring gene STARR-seq mESC enhancer starr_42100 Neighboring gene predicted gene, 41549 Neighboring gene insulin-like growth factor binding protein, acid labile subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables single-stranded DNA 3'-5' DNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables single-stranded DNA 3'-5' DNA exonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    meiosis-specific with OB domain-containing protein
    Names
    protein expressed in male leptotene and zygotene spermatocytes 675

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029197.1NP_083473.1  meiosis-specific with OB domain-containing protein

      See identical proteins and their annotated locations for NP_083473.1

      Status: VALIDATED

      Source sequence(s)
      AC166102
      Consensus CDS
      CCDS50020.1
      UniProtKB/Swiss-Prot
      E9QLG1, Q9D513
      UniProtKB/TrEMBL
      A0A3Q4EGA1
      Related
      ENSMUSP00000024972.6, ENSMUST00000024972.7
      Conserved Domains (2) summary
      cd04475
      Location:167269
      RPA1_DBD_B; A subfamily of OB folds corresponding to the third OB fold, the ssDNA-binding domain (DBD)-B, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be ...
      TIGR00617
      Location:165408
      rpa1; replication factor-a protein 1 (rpa1)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      25023275..25058762
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525045.4XP_006525108.1  meiosis-specific with OB domain-containing protein isoform X1

      See identical proteins and their annotated locations for XP_006525108.1

      UniProtKB/Swiss-Prot
      E9QLG1, Q9D513
      UniProtKB/TrEMBL
      A0A3Q4EGA1
      Conserved Domains (2) summary
      cd04475
      Location:167269
      RPA1_DBD_B; A subfamily of OB folds corresponding to the third OB fold, the ssDNA-binding domain (DBD)-B, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be ...
      TIGR00617
      Location:165408
      rpa1; replication factor-a protein 1 (rpa1)
    2. XM_017317702.2XP_017173191.1  meiosis-specific with OB domain-containing protein isoform X2

      UniProtKB/TrEMBL
      A0A3Q4EGA1
      Conserved Domains (2) summary
      cd04475
      Location:167269
      RPA1_DBD_B; A subfamily of OB folds corresponding to the third OB fold, the ssDNA-binding domain (DBD)-B, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be ...
      TIGR00617
      Location:165405
      rpa1; replication factor-a protein 1 (rpa1)
    3. XM_006525047.4XP_006525110.1  meiosis-specific with OB domain-containing protein isoform X1

      See identical proteins and their annotated locations for XP_006525110.1

      UniProtKB/Swiss-Prot
      E9QLG1, Q9D513
      UniProtKB/TrEMBL
      A0A3Q4EGA1
      Conserved Domains (2) summary
      cd04475
      Location:167269
      RPA1_DBD_B; A subfamily of OB folds corresponding to the third OB fold, the ssDNA-binding domain (DBD)-B, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be ...
      TIGR00617
      Location:165408
      rpa1; replication factor-a protein 1 (rpa1)
    4. XM_006525048.5XP_006525111.1  meiosis-specific with OB domain-containing protein isoform X1

      See identical proteins and their annotated locations for XP_006525111.1

      UniProtKB/Swiss-Prot
      E9QLG1, Q9D513
      UniProtKB/TrEMBL
      A0A3Q4EGA1
      Conserved Domains (2) summary
      cd04475
      Location:167269
      RPA1_DBD_B; A subfamily of OB folds corresponding to the third OB fold, the ssDNA-binding domain (DBD)-B, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be ...
      TIGR00617
      Location:165408
      rpa1; replication factor-a protein 1 (rpa1)
    5. XM_006525052.4XP_006525115.1  meiosis-specific with OB domain-containing protein isoform X3

      UniProtKB/TrEMBL
      A0A3Q4EGA1
      Conserved Domains (2) summary
      cd04475
      Location:45147
      RPA1_DBD_B; A subfamily of OB folds corresponding to the third OB fold, the ssDNA-binding domain (DBD)-B, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be ...
      TIGR00617
      Location:43286
      rpa1; replication factor-a protein 1 (rpa1)