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    Kifbp kinesin family binding protein [ Mus musculus (house mouse) ]

    Gene ID: 72320, updated on 8-May-2024

    Summary

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    Official Symbol
    Kifbpprovided by MGI
    Official Full Name
    kinesin family binding proteinprovided by MGI
    Primary source
    MGI:MGI:1919570
    See related
    Ensembl:ENSMUSG00000036955 AllianceGenome:MGI:1919570
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KBP; Kif1bp; mKIAA1279; 0710007C18Rik; 2510003E04Rik
    Summary
    Predicted to enable kinesin binding activity. Acts upstream of or within in utero embryonic development. Predicted to be located in mitochondrion. Is expressed in several structures, including brain; gut; and liver. Used to study Goldberg-Shprintzen syndrome. Human ortholog(s) of this gene implicated in Goldberg-Shprintzen syndrome. Orthologous to human KIFBP (kinesin family binding protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cortex adult (RPKM 29.4), cerebellum adult (RPKM 28.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kifbp in Genome Data Viewer
    Location:
    10 B4; 10 32.43 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (62394249..62414846, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (62558470..62579066, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene VPS26 retromer complex component A Neighboring gene STARR-seq mESC enhancer starr_26885 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:61949721-61949830 Neighboring gene STARR-seq mESC enhancer starr_26886 Neighboring gene STARR-positive B cell enhancer ABC_E6862 Neighboring gene STARR-positive B cell enhancer ABC_E6863 Neighboring gene STARR-positive B cell enhancer ABC_E6864 Neighboring gene serglycin Neighboring gene STARR-positive B cell enhancer ABC_E10614 Neighboring gene STARR-positive B cell enhancer ABC_E2327 Neighboring gene STARR-positive B cell enhancer ABC_E11441 Neighboring gene STARR-seq mESC enhancer starr_26888 Neighboring gene STARR-positive B cell enhancer ABC_E3889 Neighboring gene STARR-positive B cell enhancer ABC_E8339 Neighboring gene DExD box helicase 21 Neighboring gene STARR-positive B cell enhancer ABC_E10615 Neighboring gene STARR-seq mESC enhancer starr_26889 Neighboring gene DExD box helicase 50 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:62114124-62114233

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Multiple Functions of KBP in Neural Development Underlie Brain Anomalies in Goldberg-Shprintzen Syndrome. Chang HY, et al. Front Mol Neurosci, 2019. PMID 31736709, Free PMC Article
    2. KIF1-binding protein interacts with KIF3A in haploid male germ cells. Lehti MS, et al. Reproduction, 2015 Sep. PMID 26245936
    3. The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells. Donato V, et al. Nat Cell Biol, 2017 Apr. PMID 28319092, Free PMC Article
    4. The novel protein KBP regulates mitochondria localization by interaction with a kinesin-like protein. Wozniak MJ, et al. BMC Cell Biol, 2005 Oct 14. PMID 16225668, Free PMC Article
    5. KBP interacts with SCG10, linking Goldberg-Shprintzen syndrome to microtubule dynamics and neuronal differentiation. Alves MM, et al. Hum Mol Genet, 2010 Sep 15. PMID 20621975, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TDH, responsible for mitochondrial production of acetyl-CoA in mouse embryonic stem cells, and the acetyltransferase GCN5L1 cooperate to acetylate Lys501 in KBP, allowing its recognition by and degradation via Fbxo15, an F-box protein transcriptionally controlled by the pluripotency core factors and repressed following differentiation.
      Title: The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells.
    2. KIF1-binding protein interacts with KIF3A in haploid male germ cells, promoting spermatid elongation.
      Title: KIF1-binding protein interacts with KIF3A in haploid male germ cells.
    3. KBP expression is up-regulated during neuronal development in mouse cortical neurons.
      Title: KBP interacts with SCG10, linking Goldberg-Shprintzen syndrome to microtubule dynamics and neuronal differentiation.
    4. KBP is a new binding partner for KIF1Balpha that is a regulator of its transport function and thus represents a new type of kinesin interacting protein.
      Title: The novel protein KBP regulates mitochondria localization by interaction with a kinesin-like protein.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2)  1 citation
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107132

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables kinesin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in central nervous system projection neuron axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron projection maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    KIF-binding protein
    Names
    KIF1 binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028197.2 → NP_082473.2  KIF-binding protein

      See identical proteins and their annotated locations for NP_082473.2

      Status: VALIDATED

      Source sequence(s)
      BC038828, BC055307, BY729088
      Consensus CDS
      CCDS23890.1
      UniProtKB/Swiss-Prot
      Q3TYD0, Q5BKR5, Q6ZPU9, Q7TPE0, Q80VQ5, Q8BZE2, Q8CFS7
      Related
      ENSMUSP00000065160.8, ENSMUST00000065887.14
      Conserved Domains (1) summary
      pfam12309
      Location:243 → 609
      KBP_C; KIF-1 binding protein C terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      62394249..62414846 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514192.5 → XP_006514255.1  KIF-binding protein isoform X1

      UniProtKB/TrEMBL
      E0CXN7
      Related
      ENSMUSP00000134770.2, ENSMUST00000159704.8
      Conserved Domains (1) summary
      pfam12309
      Location:243 → 325
      KBP_C; KIF-1 binding protein C terminal
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZPU9.2 GenPept UniProtKB/Swiss-Prot:Q6ZPU9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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