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    Srbd1 S1 RNA binding domain 1 [ Mus musculus (house mouse) ]

    Gene ID: 78586, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Srbd1provided by MGI
    Official Full Name
    S1 RNA binding domain 1provided by MGI
    Primary source
    MGI:MGI:1925836
    See related
    Ensembl:ENSMUSG00000024135 AllianceGenome:MGI:1925836
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D530025C17Rik
    Summary
    Predicted to enable mRNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Is expressed in olfactory epithelium and thymus primordium. Orthologous to human SRBD1 (S1 RNA binding domain 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 1.0), CNS E14 (RPKM 0.7) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Srbd1 in Genome Data Viewer
    Location:
    17 E4; 17 56.51 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (86292093..86452644, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (85984665..86145216, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43474 Neighboring gene predicted gene 29418 Neighboring gene predicted gene 4718 Neighboring gene predicted gene, 30117 Neighboring gene predicted gene, 53966 Neighboring gene STARR-seq mESC enhancer starr_43477 Neighboring gene STARR-positive B cell enhancer ABC_E10975 Neighboring gene STARR-seq mESC enhancer starr_43480 Neighboring gene STARR-positive B cell enhancer ABC_E1511 Neighboring gene STARR-seq mESC enhancer starr_43481 Neighboring gene predicted gene 5817 Neighboring gene protein kinase C, epsilon Neighboring gene predicted gene, 52296

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article
    2. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC117756, MGC198776

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleobase-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    S1 RNA-binding domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030133.3 → NP_084409.3  S1 RNA-binding domain-containing protein 1

      Status: VALIDATED

      Source sequence(s)
      AC154185, AC154542
      Consensus CDS
      CCDS50204.1
      UniProtKB/Swiss-Prot
      Q497V5
      UniProtKB/TrEMBL
      F8WGW3
      Related
      ENSMUSP00000092810.4, ENSMUST00000095187.4
      Conserved Domains (1) summary
      COG2183
      Location:205 → 978
      Tex; Transcriptional accessory protein Tex/SPT6 [Transcription]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      86292093..86452644 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246728.1 → XP_011245030.1  S1 RNA-binding domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011245030.1

      UniProtKB/Swiss-Prot
      Q497V5
      Conserved Domains (2) summary
      COG2183
      Location:205 → 992
      Tex; Transcriptional accessory protein Tex/SPT6 [Transcription]
      pfam05793
      Location:9 → 186
      TFIIF_alpha; Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)

    2. XM_036160847.1 → XP_036016740.1  S1 RNA-binding domain-containing protein 1 isoform X6

      Conserved Domains (1) summary
      COG2183
      Location:21 → 601
      Tex; Transcriptional accessory protein Tex/SPT6 [Transcription]

    3. XM_011246731.4 → XP_011245033.1  S1 RNA-binding domain-containing protein 1 isoform X5

      Conserved Domains (1) summary
      COG2183
      Location:21 → 615
      Tex; Transcriptional accessory protein Tex/SPT6 [Transcription]

    4. XM_036160846.1 → XP_036016739.1  S1 RNA-binding domain-containing protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q497V5
      Conserved Domains (1) summary
      COG2183
      Location:205 → 822
      Tex; Transcriptional accessory protein Tex/SPT6 [Transcription]

    5. XM_017317728.1 → XP_017173217.1  S1 RNA-binding domain-containing protein 1 isoform X3

      Conserved Domains (2) summary
      COG2183
      Location:205 → 678
      Tex; Transcriptional accessory protein Tex/SPT6 [Transcription]
      pfam05793
      Location:9 → 186
      TFIIF_alpha; Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)

    6. XM_011246730.2 → XP_011245032.1  S1 RNA-binding domain-containing protein 1 isoform X4

      Conserved Domains (2) summary
      COG2183
      Location:205 → 619
      Tex; Transcriptional accessory protein Tex/SPT6 [Transcription]
      pfam05793
      Location:9 → 186
      TFIIF_alpha; Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)

    RNA

    1. XR_385394.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q497V5.3 GenPept UniProtKB/Swiss-Prot:Q497V5

    Gene LinkOut

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