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    Capn11 calpain 11 [ Mus musculus (house mouse) ]

    Gene ID: 268958, updated on 12-May-2024

    Summary

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    Official Symbol
    Capn11provided by MGI
    Official Full Name
    calpain 11provided by MGI
    Primary source
    MGI:MGI:1352490
    See related
    Ensembl:ENSMUSG00000058626 AllianceGenome:MGI:1352490
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable calcium-dependent cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Located in acrosomal vesicle. Is expressed in spermatocyte and testis. Orthologous to human CAPN11 (calpain 11). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 8.5), cerebellum adult (RPKM 1.0) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Capn11 in Genome Data Viewer
    Location:
    17 C; 17 22.59 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (45941117..45970400, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (45630191..45659709, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42635 Neighboring gene STARR-seq mESC enhancer starr_42636 Neighboring gene myomixer, myoblast fusion factor Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:45756550-45756733 Neighboring gene predicted gene, 52283 Neighboring gene STARR-positive B cell enhancer ABC_E9955 Neighboring gene predicted gene, 25008 Neighboring gene STARR-positive B cell enhancer ABC_E10956 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:45775877-45776144 Neighboring gene transmembrane protein 63b Neighboring gene STARR-positive B cell enhancer ABC_E7534 Neighboring gene mitochondrial ribosomal protein L14 Neighboring gene predicted gene, 35456

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Calpain-cleaved collapsin response mediator protein-3 induces neuronal death after glutamate toxicity and cerebral ischemia. Hou ST, et al. J Neurosci, 2006 Feb 22. PMID 16495451, Free PMC Article
    2. Calpain 11 is unique to mouse spermatogenic cells. Ben-Aharon I, et al. Mol Reprod Dev, 2006 Jun. PMID 16541461, Free PMC Article
    3. Diverse mRNA expression patterns of the mouse calpain genes Capn5, Capn6 and Capn11 during development. Dear TN, et al. Mech Dev, 1999 Dec. PMID 10559499
    4. Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice. Miyata H, et al. Proc Natl Acad Sci U S A, 2016 Jul 12. PMID 27357688, Free PMC Article
    5. In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Gineste C, et al. Neuromuscul Disord, 2013 Apr. PMID 23375831

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    calpain-11
    Names
    CANP 11
    calcium-activated neutral proteinase 11
    calcium-dependent thiol protease
    NP_001013789.1
    XP_011244781.1
    XP_011244782.1
    XP_017172975.1
    XP_017172976.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013767.2 → NP_001013789.1  calpain-11

      See identical proteins and their annotated locations for NP_001013789.1

      Status: PROVISIONAL

      Source sequence(s)
      AC165259
      Consensus CDS
      CCDS50121.1
      UniProtKB/Swiss-Prot
      Q6J756
      Related
      ENSMUSP00000113132.2, ENSMUST00000120717.8
      Conserved Domains (3) summary
      cd00051
      Location:591 → 641
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00648
      Location:56 → 352
      Peptidase_C2; Calpain family cysteine protease
      pfam01067
      Location:367 → 520
      Calpain_III; Calpain large subunit, domain III

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      45941117..45970400 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246479.4 → XP_011244781.1  calpain-11 isoform X1

      Conserved Domains (3) summary
      cd16193
      Location:586 → 753
      EFh_PEF_CAPN11; Penta-EF hand, calcium binding motifs, found in calpain-11 (CAPN11)
      pfam00648
      Location:95 → 391
      Peptidase_C2; Calpain family cysteine protease
      pfam01067
      Location:413 → 559
      Calpain_III; Calpain large subunit, domain III

    2. XM_017317486.2 → XP_017172975.1  calpain-11 isoform X3

      Conserved Domains (3) summary
      cd16193
      Location:255 → 422
      EFh_PEF_CAPN11; Penta-EF hand, calcium binding motifs, found in calpain-11 (CAPN11)
      pfam01067
      Location:82 → 228
      Calpain_III; Calpain large subunit, domain III
      cl00051
      Location:44 → 66
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.

    3. XM_011246480.4 → XP_011244782.1  calpain-11 isoform X2

      Conserved Domains (2) summary
      cd00214
      Location:405 → 492
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
      pfam00648
      Location:95 → 391
      Peptidase_C2; Calpain family cysteine protease

    4. XM_017317487.3 → XP_017172976.1  calpain-11 isoform X4

      Conserved Domains (1) summary
      pfam00648
      Location:95 → 374
      Peptidase_C2; Calpain family cysteine protease

    RNA

    1. XR_876510.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6J756.1 GenPept UniProtKB/Swiss-Prot:Q6J756

    Gene LinkOut

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