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    D2HGDH D-2-hydroxyglutarate dehydrogenase [ Homo sapiens (human) ]

    Gene ID: 728294, updated on 3-Apr-2024

    Summary

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    Official Symbol
    D2HGDHprovided by HGNC
    Official Full Name
    D-2-hydroxyglutarate dehydrogenaseprovided by HGNC
    Primary source
    HGNC:HGNC:28358
    See related
    Ensembl:ENSG00000180902 MIM:609186; AllianceGenome:HGNC:28358
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    D2HGD
    Summary
    This gene encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family. This enzyme, which is most active in liver and kidney but also active in heart and brain, converts D-2-hydroxyglutarate to 2-ketoglutarate. Mutations in this gene are present in D-2-hydroxyglutaric aciduria, a rare recessive neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in skin (RPKM 9.9), kidney (RPKM 7.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See D2HGDH in Genome Data Viewer
    Location:
    2q37.3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (241734630..241768811)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (242238652..242271341)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (242674045..242708226)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12553 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:242626177-242626439 Neighboring gene deoxythymidylate kinase Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242640872-242641704 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242641943-242642572 Neighboring gene inhibitor of growth family member 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12557 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12558 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12559 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17431 Neighboring gene MPRA-validated peak4107 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242703699-242704312 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242710178-242711090 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:242714429-242715049 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242716291-242716911 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242716912-242717532 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:242717533-242718152 Neighboring gene galactose-3-O-sulfotransferase 2 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:242727152-242728351 Neighboring gene CEB1 minisatellite repeat instability region Neighboring gene uncharacterized LOC124905349 Neighboring gene neuraminidase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. D-2-hydroxyglutarate dehydrogenase in breast carcinoma as a potent prognostic marker associated with proliferation. Hayashi C, et al. Histol Histopathol, 2021 Oct. PMID 34296423
    2. Structure, substrate specificity, and catalytic mechanism of human D-2-HGDH and insights into pathogenicity of disease-associated mutations. Yang J, et al. Cell Discov, 2021 Jan 12. PMID 33431826, Free PMC Article
    3. Biochemical characterization of human D-2-hydroxyglutarate dehydrogenase and two disease related variants reveals the molecular cause of D-2-hydroxyglutaric aciduria. Toplak M, et al. Biochim Biophys Acta Proteins Proteom, 2019 Nov. PMID 31349060
    4. D-2-hydroxyglutaric aciduria Type I: Functional analysis of D2HGDH missense variants. Pop A, et al. Hum Mutat, 2019 Jul. PMID 30908763, Free PMC Article
    5. D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2. Lin AP, et al. Nat Commun, 2015 Jul 16. PMID 26178471, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. D-2-hydroxyglutarate dehydrogenase in breast carcinoma as a potent prognostic marker associated with proliferation.
      Title: D-2-hydroxyglutarate dehydrogenase in breast carcinoma as a potent prognostic marker associated with proliferation.
    2. MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome.
      Title: MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome.
    3. Adult diffuse glioma GWAS by molecular subtype identifies variants in D2HGDH and FAM20C.
      Title: Adult diffuse glioma GWAS by molecular subtype identifies variants in D2HGDH and FAM20C.
    4. Study presents the functional characterization of 31 D2HGDH missense variants, and the identification of 10 novel variants in a large cohort of patients with D-2-hydroxyglutaric aciduria Type I. The functional tests proved effective in classifying missense variants associated with severely impaired D-2-HGDH activity.
      Title: D-2-hydroxyglutaric aciduria Type I: Functional analysis of D2HGDH missense variants.
    5. hD2HGDH directly reduces recombinant human ETF, thus establishing a metabolic link between the oxidation of D-2-hydroxyglutarate and the mitochondrial electron transport chain.
      Title: Biochemical characterization of human D-2-hydroxyglutarate dehydrogenase and two disease related variants reveals the molecular cause of D-2-hydroxyglutaric aciduria.
    6. D2HGDH-GAL3ST2 is more frequently seen in prostate cancer samples, and seems to be enriched in African Americans.
      Title: Recurrent cis-SAGe chimeric RNA, D2HGDH-GAL3ST2, in prostate cancer.
    7. D2HGDH elevates alpha-KG levels via IDH2 expression modulation, influencing histone and DNA methylation, and HIF1alpha hydroxylation. D2HGDH mutants found in diffuse large B-cell lymphoma are enzymatically inert.
      Title: D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2.
    8. D2HGDH mutation is not associated with glioblastoma.
      Title: Screen for IDH1, IDH2, IDH3, D2HGDH and L2HGDH mutations in glioblastoma.
    9. We did not find evidence for mutations in the genes D2HGDH and L2HGDH as an alternative mechanism for raised 2-hydroxyglutarate levels in brain tumours
      Title: Mutational analysis of D2HGDH and L2HGDH in brain tumours without IDH1 or IDH2 mutations.
    10. Observational study of gene-disease association. (HuGE Navigator)
      Title: Mutational analysis of D2HGDH and L2HGDH in brain tumours without IDH1 or IDH2 mutations.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    D-2-hydroxyglutaric aciduria 1
    MedGen: C3152055 OMIM: 600721 GeneReviews: Not available
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ42195, MGC25181

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables (R)-2-hydroxyglutarate dehydrogenase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables (R)-2-hydroxyglutarate dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables (R)-2-hydroxyglutarate dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 2-oxoglutarate metabolic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in malate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    NOT involved_in response to calcium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in response to cobalt ion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    NOT involved_in response to magnesium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in response to manganese ion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in response to zinc ion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    D-2-hydroxyglutarate dehydrogenase, mitochondrial
    NP_001274178.1
    NP_001339753.1
    NP_689996.4
    XP_011510040.1
    XP_011510041.1
    XP_011510042.1
    XP_011510043.1
    XP_011510045.1
    XP_011510048.1
    XP_011510049.1
    XP_011510052.1
    XP_011510054.1
    XP_011510058.1
    XP_011510059.1
    XP_011510060.1
    XP_011510061.1
    XP_011510062.1
    XP_016860316.1
    XP_016860318.1
    XP_016860319.1
    XP_047301643.1
    XP_047301648.1
    XP_047301649.1
    XP_047301650.1
    XP_047301652.1
    XP_047301664.1
    XP_047301666.1
    XP_047301668.1
    XP_047301673.1
    XP_047301674.1
    XP_047301675.1
    XP_047301676.1
    XP_054199651.1
    XP_054199652.1
    XP_054199653.1
    XP_054199654.1
    XP_054199655.1
    XP_054199656.1
    XP_054199657.1
    XP_054199658.1
    XP_054199659.1
    XP_054199660.1
    XP_054199661.1
    XP_054199662.1
    XP_054199663.1
    XP_054199664.1
    XP_054199665.1
    XP_054199666.1
    XP_054199667.1
    XP_054199668.1
    XP_054199669.1
    XP_054199670.1
    XP_054199671.1
    XP_054199672.1
    XP_054199673.1
    XP_054199674.1
    XP_054199675.1
    XP_054199676.1
    XP_054199677.1
    XP_054199678.1
    XP_054199679.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012012.1 RefSeqGene

      Range
      5016..39197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001287249.2 → NP_001274178.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK094149, AK304764, AK304773, BC031817, BC036604, BC073980
      Consensus CDS
      CCDS74684.1
      UniProtKB/TrEMBL
      B3KSR6, B5MCV2
      Related
      ENSP00000384723.1, ENST00000403782.5
      Conserved Domains (1) summary
      COG0277
      Location:2 → 386
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]

    2. NM_001352824.2 → NP_001339753.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC114730
      UniProtKB/TrEMBL
      B3KSR6
      Conserved Domains (1) summary
      COG0277
      Location:2 → 333
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]

    3. NM_152783.5 → NP_689996.4  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      AK304764, AK304773, BC031817, BC036604, BC071598
      Consensus CDS
      CCDS33426.1
      UniProtKB/Swiss-Prot
      B4E3L6, E7ENP2, Q6IQ24, Q8N465, Q8N5Q8
      Related
      ENSP00000315351.4, ENST00000321264.9
      Conserved Domains (3) summary
      COG0277
      Location:69 → 520
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
      pfam01565
      Location:101 → 238
      FAD_binding_4; FAD binding domain
      pfam02913
      Location:275 → 515
      FAD-oxidase_C; FAD linked oxidases, C-terminal domain

    RNA

    1. NR_109778.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK091725, AK304764, AK304773, BC031817, BC073980
      Related
      ENST00000400769.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      241734630..241768811
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011511750.4 → XP_011510052.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X13

      Conserved Domains (3) summary
      COG0277
      Location:69 → 408
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
      pfam01565
      Location:101 → 238
      FAD_binding_4; FAD binding domain
      pfam02913
      Location:311 → 408
      FAD-oxidase_C; FAD linked oxidases, C-terminal domain

    2. XM_047445718.1 → XP_047301674.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X15

    3. XM_011511756.3 → XP_011510058.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X18

      Conserved Domains (1) summary
      COG0277
      Location:69 → 370
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]

    4. XM_047445694.1 → XP_047301650.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X6

    5. XM_011511743.3 → XP_011510045.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X6

      Conserved Domains (2) summary
      COG0277
      Location:69 → 286
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
      pfam01565
      Location:101 → 238
      FAD_binding_4; FAD binding domain

    6. XM_047445696.1 → XP_047301652.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X6

    7. XM_047445710.1 → XP_047301666.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X11

    8. XM_017004830.3 → XP_016860319.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X10

    9. XM_017004829.3 → XP_016860318.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X6

      Conserved Domains (2) summary
      COG0277
      Location:69 → 286
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
      pfam01565
      Location:101 → 238
      FAD_binding_4; FAD binding domain

    10. XM_047445712.1 → XP_047301668.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X12

    11. XM_047445708.1 → XP_047301664.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X7

    12. XM_011511757.4 → XP_011510059.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X19

      UniProtKB/TrEMBL
      B4E3K7
      Conserved Domains (3) summary
      COG0277
      Location:69 → 286
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
      pfam01565
      Location:101 → 238
      FAD_binding_4; FAD binding domain
      pfam02913
      Location:311 → 356
      FAD-oxidase_C; FAD linked oxidases, C-terminal domain

    13. XM_047445693.1 → XP_047301649.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X4

    14. XM_047445719.1 → XP_047301675.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X17

    15. XM_011511738.4 → XP_011510040.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X1

      Conserved Domains (2) summary
      COG0277
      Location:69 → 286
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
      pfam01565
      Location:101 → 238
      FAD_binding_4; FAD binding domain

    16. XM_011511759.4 → XP_011510061.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X20

      UniProtKB/TrEMBL
      B4E3K7
      Conserved Domains (2) summary
      COG0277
      Location:69 → 286
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
      pfam01565
      Location:101 → 238
      FAD_binding_4; FAD binding domain

    17. XM_011511740.4 → XP_011510042.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X1

      Conserved Domains (2) summary
      COG0277
      Location:69 → 286
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
      pfam01565
      Location:101 → 238
      FAD_binding_4; FAD binding domain

    18. XM_047445692.1 → XP_047301648.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X2

    19. XM_047445717.1 → XP_047301673.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X14

    20. XM_047445687.1 → XP_047301643.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X1

    21. XM_011511739.3 → XP_011510041.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X1

      Conserved Domains (2) summary
      COG0277
      Location:69 → 286
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
      pfam01565
      Location:101 → 238
      FAD_binding_4; FAD binding domain

    22. XM_017004827.3 → XP_016860316.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X3

    23. XM_011511741.4 → XP_011510043.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X5

      Conserved Domains (2) summary
      COG0277
      Location:69 → 286
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
      pfam01565
      Location:101 → 238
      FAD_binding_4; FAD binding domain

    24. XM_011511752.3 → XP_011510054.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X16

      Conserved Domains (2) summary
      COG0277
      Location:69 → 286
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
      pfam01565
      Location:101 → 238
      FAD_binding_4; FAD binding domain

    25. XM_011511747.4 → XP_011510049.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X9

      Conserved Domains (2) summary
      COG0277
      Location:69 → 286
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
      pfam01565
      Location:101 → 238
      FAD_binding_4; FAD binding domain

    26. XM_047445720.1 → XP_047301676.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X20

    27. XM_011511760.4 → XP_011510062.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X21

      UniProtKB/TrEMBL
      B4E3K7
      Conserved Domains (2) summary
      COG0277
      Location:69 → 286
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
      pfam01565
      Location:101 → 238
      FAD_binding_4; FAD binding domain

    28. XM_011511758.4 → XP_011510060.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X20

      UniProtKB/TrEMBL
      B4E3K7
      Conserved Domains (2) summary
      COG0277
      Location:69 → 286
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
      pfam01565
      Location:101 → 238
      FAD_binding_4; FAD binding domain

    29. XM_011511746.4 → XP_011510048.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X8

      Conserved Domains (2) summary
      COG0277
      Location:69 → 339
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
      pfam01565
      Location:101 → 238
      FAD_binding_4; FAD binding domain

    RNA

    1. XR_007081557.1 RNA Sequence

    2. XR_007081578.1 RNA Sequence

    3. XR_923016.4 RNA Sequence

    4. XR_923015.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      242238652..242271341
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054343694.1 → XP_054199669.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X13

    2. XM_054343696.1 → XP_054199671.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X15

    3. XM_054343699.1 → XP_054199674.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X18

    4. XM_054343684.1 → XP_054199659.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X6

    5. XM_054343686.1 → XP_054199661.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X6

    6. XM_054343685.1 → XP_054199660.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X6

    7. XM_054343692.1 → XP_054199667.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X11

    8. XM_054343691.1 → XP_054199666.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X10

    9. XM_054343687.1 → XP_054199662.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X6

    10. XM_054343693.1 → XP_054199668.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X12

    11. XM_054343688.1 → XP_054199663.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X7

    12. XM_054343700.1 → XP_054199675.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X19

    13. XM_054343682.1 → XP_054199657.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X4

    14. XM_054343698.1 → XP_054199673.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X17

    15. XM_054343677.1 → XP_054199652.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X1

    16. XM_054343703.1 → XP_054199678.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X20

    17. XM_054343679.1 → XP_054199654.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X1

    18. XM_054343680.1 → XP_054199655.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X2

    19. XM_054343695.1 → XP_054199670.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X14

    20. XM_054343676.1 → XP_054199651.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X1

    21. XM_054343678.1 → XP_054199653.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X1

    22. XM_054343681.1 → XP_054199656.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X3

    23. XM_054343683.1 → XP_054199658.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X5

    24. XM_054343697.1 → XP_054199672.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X16

    25. XM_054343690.1 → XP_054199665.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X9

    26. XM_054343701.1 → XP_054199676.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X20

    27. XM_054343704.1 → XP_054199679.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X21

    28. XM_054343702.1 → XP_054199677.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X20

    29. XM_054343689.1 → XP_054199664.1  D-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X8

    RNA

    1. XR_008486500.1 RNA Sequence

    2. XR_008486501.1 RNA Sequence

    3. XR_008486503.1 RNA Sequence

    4. XR_008486502.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N465.3 GenPept UniProtKB/Swiss-Prot:Q8N465

    Gene LinkOut

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