IL22 interleukin 22 [Homo sapiens (human)] - Gene

Summary

Official Symbol: IL22provided by HGNC
Official Full Name: interleukin 22provided by HGNC
Primary source: HGNC:HGNC:14900
See related: Ensembl:ENSG00000127318 MIM:605330; AllianceGenome:HGNC:14900
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TIFa; IL-21; IL-22; ILTIF; IL-TIF; IL-D110; zcyto18; TIFIL-23
Summary: This gene is a member of the IL10 family of cytokines that mediate cellular inflammatory responses. The encoded protein functions in antimicrobial defense at mucosal surfaces and in tissue repair. This protein also has pro-inflammatory properties and plays a role in in the pathogenesis of several intestinal diseases. The encoded protein is a crucial cytokine that regulates host immunity in infectious diseases, including COVID-19 (disease caused by SARS-CoV-2). [provided by RefSeq, Dec 2021]
Annotation information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.; Note: This gene (GeneID: 50616) was identified as IL-21 or IL-TIF in PMID: 10954742. The official symbol for this gene is now IL22. [19 May 2011]
Expression: Low expression observed in reference dataset See more
Orthologs: all
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Genomic context

Location:: 12q15

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (68248242..68253604, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (68227763..68233125, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (68642022..68647384, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interleukin-22 inhibits cardiac fibrosis by regulating fibroblast metabolic reprogramming in myocardial infarction.
Title: Interleukin-22 inhibits cardiac fibrosis by regulating fibroblast metabolic reprogramming in myocardial infarction.
Interleukin-22 enhanced the mucosal barrier and inhibited the invasion of Salmonella enterica in human-induced pluripotent stem cell-derived small intestinal epithelial cells.
Title: Interleukin-22 enhanced the mucosal barrier and inhibited the invasion of Salmonella enterica in human-induced pluripotent stem cell-derived small intestinal epithelial cells.
Unraveling IL-17 and IL-22 role in occult hepatitis C versus chronic hepatitis C virus infection.
Title: Unraveling IL-17 and IL-22 role in occult hepatitis C versus chronic hepatitis C virus infection.
Pro-osteogenic role of interleukin-22 in calcific aortic valve disease.
Title: Pro-osteogenic role of interleukin-22 in calcific aortic valve disease.
IL-22 is secreted by proximal tubule cells and regulates DNA damage response and cell death in acute kidney injury.
Title: IL-22 is secreted by proximal tubule cells and regulates DNA damage response and cell death in acute kidney injury.
Gut microbiota-mediated IL-22 alleviates metabolic inflammation.
Title: Gut microbiota-mediated IL-22 alleviates metabolic inflammation.
Interleukin-22 and acute pancreatitis: A review.
Title: Interleukin-22 and acute pancreatitis: A review.
Interleukin-22 Inhibits Apoptosis of Gingival Epithelial Cells Through TGF-beta Signaling Pathway During Periodontitis.
Title: Interleukin-22 Inhibits Apoptosis of Gingival Epithelial Cells Through TGF-β Signaling Pathway During Periodontitis.
CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis.
Title: CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis.
Screening of IL-22 first and second introns and FOXP3 second exon for SNPs and mutations with potential role in the susceptibility of SLE in selected population.
Title: Screening of IL-22 first and second introns and FOXP3 second exon for SNPs and mutations with potential role in the susceptibility of SLE in selected population.

Submit: New GeneRIF Correction See all GeneRIFs (387)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

IL22_1342 (e-PCR)
- UniSTS:277376

NoName (e-PCR)
- UniSTS:480747

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cytokine activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables interleukin-22 receptor binding	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in acute-phase response	NAS Non-traceable Author Statement more info	PubMed
involved_in inflammatory response	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in response to glucocorticoid	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: interleukin-22

Names: IL-10-related T-cell-derived inducible factor; cytokine Zcyto18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.