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    Ipo4 importin 4 [ Mus musculus (house mouse) ]

    Gene ID: 75751, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Ipo4provided by MGI
    Official Full Name
    importin 4provided by MGI
    Primary source
    MGI:MGI:1923001
    See related
    Ensembl:ENSMUSG00000002319 AllianceGenome:MGI:1923001
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Imp4a; RanBP4; 8430408O15Rik
    Summary
    Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in DNA replication-dependent chromatin assembly; DNA replication-independent chromatin assembly; and protein import into nucleus. Predicted to act upstream of or within ribosome biogenesis. Predicted to be located in chromatin. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Is expressed in retina outer nuclear layer. Orthologous to human IPO4 (importin 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 123.0), ovary adult (RPKM 46.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ipo4 in Genome Data Viewer
    Location:
    14 C3; 14 28.19 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55862857..55873321, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55625400..55635868, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:56222707-56223021 Neighboring gene interferon regulatory factor 9 Neighboring gene REC8 meiotic recombination protein Neighboring gene transmembrane 9 superfamily member 1 Neighboring gene testis-specific serine kinase 4 Neighboring gene magnesium-dependent phosphatase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Distinct effects of importin α2 and α4 on Oct3/4 localization and expression in mouse embryonic stem cells. Young JC, et al. FASEB J, 2011 Nov. PMID 21840941
    2. Involvement of importin-4 in the transport of transition protein 2 into the spermatid nucleus. Pradeepa MM, et al. Mol Cell Biol, 2008 Jul. PMID 17682055, Free PMC Article
    3. CCAAT/enhancer binding protein delta (C/EBPdelta, CEBPD)-mediated nuclear import of FANCD2 by IPO4 augments cellular response to DNA damage. Wang J, et al. Proc Natl Acad Sci U S A, 2010 Sep 14. PMID 20805509, Free PMC Article
    4. The role of metallothionein in the pathogenesis of acute lung injury. Wesselkamper SC, et al. Am J Respir Cell Mol Biol, 2006 Jan. PMID 16166738, Free PMC Article
    5. Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains. Jäkel S, et al. EMBO J, 2002 Feb 1. PMID 11823430, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. report a function of IPO4 and nuclear import in the Fanconi anemia pathway of DNA repair
      Title: CCAAT/enhancer binding protein delta (C/EBPdelta, CEBPD)-mediated nuclear import of FANCD2 by IPO4 augments cellular response to DNA damage.
    2. Metallothionein deficient mice have a marked decrease in Importin 4 transcripts during acute lung injury
      Title: The role of metallothionein in the pathogenesis of acute lung injury.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC113723

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear import signal receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear localization sequence binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ribosome biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    importin-4
    Names
    imp4
    importin 4a
    ran-binding protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360078.1 → NP_001347007.1  importin-4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK030490, AK147086, BM950244
      Conserved Domains (3) summary
      smart00913
      Location:24 → 90
      IBN_N; Importin-beta N-terminal domain
      COG5215
      Location:353 → 620
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:353 → 381
      HEAT; HEAT repeat [structural motif]

    2. NM_024267.7 → NP_077229.4  importin-4 isoform 1

      See identical proteins and their annotated locations for NP_077229.4

      Status: VALIDATED

      Source sequence(s)
      AK030490, AK147086
      Consensus CDS
      CCDS27121.1
      UniProtKB/Swiss-Prot
      Q3TBW0, Q8VI75, Q99J52
      Related
      ENSMUSP00000036555.10, ENSMUST00000047131.16
      Conserved Domains (2) summary
      smart00913
      Location:24 → 90
      IBN_N; Importin-beta N-terminal domain
      sd00044
      Location:353 → 381
      HEAT; HEAT repeat [structural motif]

    RNA

    1. NR_153401.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK030490, AK147086, BC085150
      Related
      ENSMUST00000135221.8

    2. NR_153402.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK018399, AK030490, AK147086
      Related
      ENSMUST00000148351.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      55862857..55873321 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316220.3 → XP_017171709.1  importin-4 isoform X1

      Conserved Domains (2) summary
      COG5215
      Location:153 → 420
      KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
      sd00044
      Location:153 → 181
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VI75.1 GenPept UniProtKB/Swiss-Prot:Q8VI75

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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