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    Eogt EGF domain specific O-linked N-acetylglucosamine transferase [ Mus musculus (house mouse) ]

    Gene ID: 101351, updated on 21-May-2024

    Summary

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    Official Symbol
    Eogtprovided by MGI
    Official Full Name
    EGF domain specific O-linked N-acetylglucosamine transferaseprovided by MGI
    Primary source
    MGI:MGI:2141669
    See related
    Ensembl:ENSMUSG00000035245 AllianceGenome:MGI:2141669
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Aer61; A130022J15Rik
    Summary
    Enables protein N-acetylglucosaminyltransferase activity. Involved in protein O-linked glycosylation. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum lumen. Is expressed in several structures, including blood vessel; central nervous system; limb; lung; and tail unsegmented mesenchyme. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome. Orthologous to human EOGT (EGF domain specific O-linked N-acetylglucosamine transferase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lung adult (RPKM 7.7), bladder adult (RPKM 7.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Eogt in Genome Data Viewer
    Location:
    6 D3; 6 44.88 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (97086977..97128445, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (97110016..97151484, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene TAFA chemokine like family member 1 Neighboring gene STARR-seq mESC enhancer starr_16762 Neighboring gene predicted gene, 26011 Neighboring gene STARR-seq mESC enhancer starr_16763 Neighboring gene STARR-seq mESC enhancer starr_16764 Neighboring gene STARR-seq mESC enhancer starr_16765 Neighboring gene STARR-seq mESC enhancer starr_16766 Neighboring gene TAFA chemokine like family member 4 Neighboring gene STARR-seq mESC enhancer starr_16767 Neighboring gene STARR-seq mESC enhancer starr_16770 Neighboring gene STARR-seq mESC enhancer starr_16771 Neighboring gene STARR-seq mESC enhancer starr_16773 Neighboring gene STARR-seq mESC enhancer starr_16775 Neighboring gene STARR-seq mESC enhancer starr_16776 Neighboring gene STARR-positive B cell enhancer ABC_E2796 Neighboring gene predicted gene, 26175 Neighboring gene TATA element modulatory factor 1 Neighboring gene ubiquitin-like modifier activating enzyme 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. N-Glycans on EGF domain-specific O-GlcNAc transferase (EOGT) facilitate EOGT maturation and peripheral endoplasmic reticulum localization. Alam SMD, et al. J Biol Chem, 2020 Jun 19. PMID 32376684, Free PMC Article
    2. Mutations in EOGT confirm the genetic heterogeneity of autosomal-recessive Adams-Oliver syndrome. Shaheen R, et al. Am J Hum Genet, 2013 Apr 4. PMID 23522784, Free PMC Article
    3. O-linked-N-acetylglucosamine modification of mammalian Notch receptors by an atypical O-GlcNAc transferase Eogt1. Sakaidani Y, et al. Biochem Biophys Res Commun, 2012 Mar 2. PMID 22310717
    4. O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals. Sawaguchi S, et al. Elife, 2017 Apr 11. PMID 28395734, Free PMC Article
    5. Cyclical expression of the Notch/Wnt regulator Nrarp requires modulation by Dll3 in somitogenesis. Sewell W, et al. Dev Biol, 2009 May 15. PMID 19268448, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EOGT enables residual Notch signaling in mouse intestinal cells lacking POFUT1.
      Title: EOGT enables residual Notch signaling in mouse intestinal cells lacking POFUT1.
    2. N-Glycans on EGF domain-specific O-GlcNAc transferase (EOGT) facilitate EOGT maturation and peripheral endoplasmic reticulum localization.
      Title: N-Glycans on EGF domain-specific O-GlcNAc transferase (EOGT) facilitate EOGT maturation and peripheral endoplasmic reticulum localization.
    3. the characterization of A130022J15Rik, a mouse gene homolog of Drosophila Eogt (Eogt 1), was reported.
      Title: O-linked-N-acetylglucosamine modification of mammalian Notch receptors by an atypical O-GlcNAc transferase Eogt1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein O-acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein O-acetylglucosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein O-GlcNAcylation via threonine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum lumen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    EGF domain-specific O-linked N-acetylglucosamine transferase
    Names
    EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
    extracellular O-linked N-acetylglucosamine transferase
    NP_780522.1
    XP_036021602.1
    XP_036021603.1
    XP_036021604.1
    XP_036021605.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175313.5 → NP_780522.1  EGF domain-specific O-linked N-acetylglucosamine transferase precursor

      See identical proteins and their annotated locations for NP_780522.1

      Status: VALIDATED

      Source sequence(s)
      AC155727
      Consensus CDS
      CCDS20383.1
      UniProtKB/Swiss-Prot
      Q8BYW9
      Related
      ENSMUSP00000061610.5, ENSMUST00000054344.11
      Conserved Domains (1) summary
      pfam04577
      Location:245 → 469
      DUF563; Protein of unknown function (DUF563)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      97086977..97128445 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165709.1 → XP_036021602.1  EGF domain-specific O-linked N-acetylglucosamine transferase isoform X1

      Conserved Domains (1) summary
      pfam04577
      Location:245 → 473
      DUF563; Protein of unknown function (DUF563)

    2. XM_036165712.1 → XP_036021605.1  EGF domain-specific O-linked N-acetylglucosamine transferase isoform X3

      Conserved Domains (1) summary
      pfam04577
      Location:2 → 228
      DUF563; Protein of unknown function (DUF563)

    3. XM_036165711.1 → XP_036021604.1  EGF domain-specific O-linked N-acetylglucosamine transferase isoform X2

      UniProtKB/Swiss-Prot
      Q8BYW9
      Conserved Domains (1) summary
      pfam04577
      Location:245 → 469
      DUF563; Protein of unknown function (DUF563)

    4. XM_036165710.1 → XP_036021603.1  EGF domain-specific O-linked N-acetylglucosamine transferase isoform X1

      Conserved Domains (1) summary
      pfam04577
      Location:245 → 473
      DUF563; Protein of unknown function (DUF563)

    RNA

    1. XR_004942885.1 RNA Sequence

    2. XR_377399.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BYW9.1 GenPept UniProtKB/Swiss-Prot:Q8BYW9

    Gene LinkOut

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