Zfp568 zinc finger protein 568 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp568provided by MGI
Official Full Name: zinc finger protein 568provided by MGI
Primary source: MGI:MGI:2142347
See related: Ensembl:ENSMUSG00000074221 AllianceGenome:MGI:2142347
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: chato; Gm1691; Znf568
Summary: Enables transcription cis-regulatory region binding activity and transcription corepressor binding activity. Involved in embryonic placenta morphogenesis and negative regulation of transcription by RNA polymerase II. Acts upstream of or within convergent extension involved in axis elongation; convergent extension involved in neural plate elongation; and regulation of cell communication. Located in nucleus. Is expressed in central nervous system; retina; and skeletal musculature. Orthologous to human ZNF568 (zinc finger protein 568). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in placenta adult (RPKM 18.4), limb E14.5 (RPKM 6.9) and 20 other tissues See more
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Genomic context

Location:: 7 B1; 7 17.26 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (29683380..29727707)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (29983955..30028282)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A placental growth factor is silenced in mouse embryos by the zinc finger protein ZFP568
Title: A placental growth factor is silenced in mouse embryos by the zinc finger protein ZFP568.
Zfp568 is both a neural stem cell-maintaining and a brain size-regulating gene.
Title: Targeted disruption in mice of a neural stem cell-maintaining, KRAB-Zn finger-encoding gene that has rapidly evolved in the human lineage.
The results revealed that TRIM28 is differentially required by ZFP568 and other factors during the early stages of mouse embryogenesis.
Title: TRIM28 is required by the mouse KRAB domain protein ZFP568 to control convergent extension and morphogenesis of extra-embryonic tissues.
ZFP568 controls the production of secreted factors required to promote morphogenesis of extraembryonic tissues.
Title: The mouse KRAB zinc-finger protein CHATO is required in embryonic-derived tissues to control yolk sac and placenta morphogenesis.
Chato regulates convergent extension in the mouse embryo.
Title: Chato, a KRAB zinc-finger protein, regulates convergent extension in the mouse embryo.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Gene trapped (2) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C80731 (e-PCR)
- UniSTS:179547

NoName (e-PCR)
- UniSTS:235643

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription corepressor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within convergent extension involved in axis elongation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within convergent extension involved in neural plate elongation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic placenta morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic placenta morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell communication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: zinc finger protein 568

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033355.3 → NP_001028527.2 zinc finger protein 568 isoform 1

See identical proteins and their annotated locations for NP_001028527.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1, and encodes isoform (1). Variants 1 and 2 encode the same protein.

Source sequence(s)

AK143471, AK148548, BC082606, BE456949

Consensus CDS

CCDS21077.1

UniProtKB/Swiss-Prot

E9PYI1, Q0VGV0, Q3UPK4

Related

ENSMUSP00000118387.2, ENSMUST00000148442.8

Conserved Domains (3) summary

smart00349
Location:34 → 94

KRAB; krueppel associated box

COG5048
Location:350 → 665

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:589 → 609

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001167872.1 → NP_001161344.1 zinc finger protein 568 isoform 1

See identical proteins and their annotated locations for NP_001161344.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes isoform (1). Variants 1 and 2 encode the same protein.

Source sequence(s)

AK148548, BC082606, BE456949

Consensus CDS

CCDS21077.1

UniProtKB/Swiss-Prot

E9PYI1, Q0VGV0, Q3UPK4

Conserved Domains (3) summary

smart00349
Location:34 → 94

KRAB; krueppel associated box

COG5048
Location:350 → 665

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:589 → 609

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001167873.1 → NP_001161345.1 zinc finger protein 568 isoform 2

See identical proteins and their annotated locations for NP_001161345.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site in the coding region, compared to variant 1, and encodes a protein (isoform 2) that is 1 aa shorter than isoform 1.

Source sequence(s)

AK148548, BC082606, BE456949

Consensus CDS

CCDS52176.1

UniProtKB/Swiss-Prot

E9PYI1

Related

ENSMUSP00000118823.2, ENSMUST00000146074.8

Conserved Domains (6) summary

smart00349
Location:34 → 94

KRAB; krueppel associated box

COG5048
Location:198 → 633

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:588 → 608

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:418 → 440

zf-C2H2; Zinc finger, C2H2 type

pfam01352
Location:34 → 73

KRAB; KRAB box

pfam13465
Location:432 → 457

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

29683380..29727707

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011250569.4 → XP_011248871.1 zinc finger protein 568 isoform X1

See identical proteins and their annotated locations for XP_011248871.1

UniProtKB/Swiss-Prot

E9PYI1, Q0VGV0, Q3UPK4

Related

ENSMUSP00000073930.6, ENSMUST00000074322.12

Conserved Domains (3) summary

smart00349
Location:34 → 94

KRAB; krueppel associated box

COG5048
Location:350 → 665

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:589 → 609

ZF_C2H2; C2H2 Zn finger [structural motif]