Akirin1 akirin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Akirin1provided by MGI
Official Full Name: akirin 1provided by MGI
Primary source: MGI:MGI:1915300
See related: Ensembl:ENSMUSG00000023075 AllianceGenome:MGI:1915300
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 6330407G11Rik
Summary: Predicted to enable transcription coregulator activity. Involved in several processes, including myoblast migration involved in skeletal muscle regeneration; negative regulation of satellite cell differentiation; and positive regulation of lamellipodium assembly. Predicted to be located in nuclear membrane and nucleoplasm. Predicted to be active in chromatin and nucleus. Is expressed in several structures, including foregut; ganglia; jaw; lung; and nose. Orthologous to human AKIRIN1 (akirin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 45.1), bladder adult (RPKM 24.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.2; 4 57.42 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (123628988..123644092, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (123735195..123750299, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

that mouse Akhirin plays a crucial role in mouse spinal cord formation by regulating the ependymal niche in the central canal
Title: Akhirin regulates the proliferation and differentiation of neural stem cells in intact and injured mouse spinal cord.
glucocorticoids stimulate myostatin which inhibits Akirin1 expression and the reparative functions of satellite cells
Title: Myostatin suppression of Akirin1 mediates glucocorticoid-induced satellite cell dysfunction.
Mighty is a critical promyogenic factor which plays a key role in the signalling pathway downstream of Myostatin.
Title: Mighty is a novel promyogenic factor in skeletal myogenesis.
myostatin regulates key steps of muscle regeneration including chemotaxis of inflammatory cells, SC activation and migration through akirin1.
Title: Akirin1 (Mighty), a novel promyogenic factor regulates muscle regeneration and cell chemotaxis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in myoblast migration involved in skeletal muscle regeneration	IBA Inferred from Biological aspect of Ancestor more info
involved_in myoblast migration involved in skeletal muscle regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of satellite cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of skeletal muscle satellite cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of skeletal muscle satellite cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lamellipodium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of lamellipodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macrophage chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of macrophage chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of myoblast differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of myoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: akirin-1

Names: mighty protein; protein mighty

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.