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    Ppie peptidylprolyl isomerase E (cyclophilin E) [ Mus musculus (house mouse) ]

    Gene ID: 56031, updated on 12-May-2024

    Summary

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    Official Symbol
    Ppieprovided by MGI
    Official Full Name
    peptidylprolyl isomerase E (cyclophilin E)provided by MGI
    Primary source
    MGI:MGI:1917118
    See related
    Ensembl:ENSMUSG00000028651 AllianceGenome:MGI:1917118
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cyp33; 2010010D16Rik
    Summary
    Predicted to enable RNA binding activity; cyclosporin A binding activity; and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in several processes, including mRNA splicing, via spliceosome; positive regulation of viral genome replication; and protein peptidyl-prolyl isomerization. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in cytosol and nuclear speck. Predicted to be part of U2-type catalytic step 2 spliceosome. Predicted to be active in cytoplasm. Is expressed in brain; cerebral cortex; and olfactory epithelium. Orthologous to human PPIE (peptidylprolyl isomerase E). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 21.0), limb E14.5 (RPKM 14.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ppie in Genome Data Viewer
    Location:
    4 D2.2; 4 57.39 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (123020907..123033783, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (123127114..123139990, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4662 Neighboring gene STARR-positive B cell enhancer ABC_E4663 Neighboring gene predicted gene 12923 Neighboring gene predicted gene, 46868 Neighboring gene bone morphogenetic protein 8b Neighboring gene predicted gene, 17244 Neighboring gene 3-oxoacid CoA transferase 2B Neighboring gene STARR-positive B cell enhancer ABC_E8988 Neighboring gene STARR-seq mESC enhancer starr_11286 Neighboring gene STARR-positive B cell enhancer ABC_E10256 Neighboring gene hippocalcin-like 4 Neighboring gene 5'-nucleotidase, cytosolic IA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Gene structure and evolution of testicular haploid germ cell-specific genes, Oxct2a and Oxct2b. Onishi M, et al. Genomics, 2004 Apr. PMID 15028287
    2. A new family of cyclophilins with an RNA recognition motif that interact with members of the trx/MLL protein family in Drosophila and human cells. Anderson M, et al. Dev Genes Evol, 2002 Apr. PMID 11976948
    3. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
    4. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclosporin A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclosporin A binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables poly(A) binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein peptidyl-prolyl isomerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein peptidyl-prolyl isomerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of U2-type catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    peptidyl-prolyl cis-trans isomerase E
    Names
    PPIase E
    cyclophilin-33
    rotamase E
    NP_062362.1
    XP_006503313.1
    XP_011238883.1
    XP_030109538.1
    XP_036020146.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019489.6 → NP_062362.1  peptidyl-prolyl cis-trans isomerase E

      See identical proteins and their annotated locations for NP_062362.1

      Status: VALIDATED

      Source sequence(s)
      AL606934
      Consensus CDS
      CCDS18610.1
      UniProtKB/Swiss-Prot
      Q9D8C0, Q9QZH3
      Related
      ENSMUSP00000030404.5, ENSMUST00000030404.5
      Conserved Domains (3) summary
      COG0724
      Location:5 → 194
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd01926
      Location:140 → 298
      cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
      cd12347
      Location:8 → 80
      RRM_PPIE; RNA recognition motif in cyclophilin-33 (Cyp33) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      123020907..123033783 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503250.4 → XP_006503313.1  peptidyl-prolyl cis-trans isomerase E isoform X1

      See identical proteins and their annotated locations for XP_006503313.1

      Conserved Domains (1) summary
      cd01926
      Location:56 → 214
      cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...

    2. XM_036164253.1 → XP_036020146.1  peptidyl-prolyl cis-trans isomerase E isoform X1

      Conserved Domains (1) summary
      cd01926
      Location:56 → 214
      cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...

    3. XM_011240581.2 → XP_011238883.1  peptidyl-prolyl cis-trans isomerase E isoform X1

      See identical proteins and their annotated locations for XP_011238883.1

      Conserved Domains (1) summary
      cd01926
      Location:56 → 214
      cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...

    4. XM_030253678.2 → XP_030109538.1  peptidyl-prolyl cis-trans isomerase E isoform X1

      Conserved Domains (1) summary
      cd01926
      Location:56 → 214
      cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZH3.2 GenPept UniProtKB/Swiss-Prot:Q9QZH3

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