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    Sprtn SprT-like N-terminal domain [ Mus musculus (house mouse) ]

    Gene ID: 244666, updated on 25-May-2024

    Summary

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    Official Symbol
    Sprtnprovided by MGI
    Official Full Name
    SprT-like N-terminal domainprovided by MGI
    Primary source
    MGI:MGI:2685351
    See related
    Ensembl:ENSMUSG00000031986 AllianceGenome:MGI:2685351
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm505
    Summary
    Predicted to enable several functions, including DNA binding activity; K63-linked polyubiquitin modification-dependent protein binding activity; and metalloendopeptidase activity. Involved in protein-DNA covalent cross-linking repair. Predicted to be located in chromatin and nuclear speck. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Ruijs-Aalfs syndrome. Orthologous to human SPRTN (SprT-like N-terminal domain). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 49.2), thymus adult (RPKM 7.8) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sprtn in Genome Data Viewer
    Location:
    8 E2; 8 72.83 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (125624612..125632903)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (124897771..124906161)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene 16163 Neighboring gene glyceronephosphate O-acyltransferase Neighboring gene exocyst complex component 8 Neighboring gene egl-9 family hypoxia-inducible factor 1 Neighboring gene predicted gene, 46060 Neighboring gene predicted gene, 39281

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis. Maskey RS, et al. Nucleic Acids Res, 2017 May 5. PMID 28199696, Free PMC Article
    2. Spartan deficiency causes genomic instability and progeroid phenotypes. Maskey RS, et al. Nat Commun, 2014 Dec 11. PMID 25501849, Free PMC Article
    3. SPRTN is a mammalian DNA-binding metalloprotease that resolves DNA-protein crosslinks. Lopez-Mosqueda J, et al. Elife, 2016 Nov 17. PMID 27852435, Free PMC Article
    4. Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging. Huang J, et al. Mol Cell, 2020 Sep 3. PMID 32649882, Free PMC Article
    5. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables K63-linked polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autoprocessing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-DNA covalent cross-linking repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein-DNA covalent cross-linking repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to UV ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translesion synthesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA-dependent metalloprotease SPRTN
    Names
    protein with SprT-like domain at the N terminus
    spartan
    sprT-like domain-containing protein Spartan
    NP_001104611.1
    XP_006531083.1
    XP_036009942.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111141.2 → NP_001104611.1  DNA-dependent metalloprotease SPRTN isoform 1

      See identical proteins and their annotated locations for NP_001104611.1

      Status: VALIDATED

      Source sequence(s)
      AC139158
      Consensus CDS
      CCDS52705.1
      UniProtKB/Swiss-Prot
      B2RY42, G3X912
      Related
      ENSMUSP00000034467.6, ENSMUST00000034467.7
      Conserved Domains (2) summary
      smart00734
      Location:462 → 485
      ZnF_Rad18; Rad18-like CCHC zinc finger
      pfam10263
      Location:46 → 214
      SprT-like; SprT-like family

    2. NM_001428364.1 → NP_001415293.1  DNA-dependent metalloprotease SPRTN isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC139158

    3. NM_001428365.1 → NP_001415294.1  DNA-dependent metalloprotease SPRTN isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC139158

    4. NM_001428366.1 → NP_001415295.1  DNA-dependent metalloprotease SPRTN isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC139158

    5. NM_001428367.1 → NP_001415296.1  DNA-dependent metalloprotease SPRTN isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC139158

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      125624612..125632903
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154049.1 → XP_036009942.1  DNA-dependent metalloprotease SPRTN isoform X1

      Conserved Domains (3) summary
      smart00734
      Location:419 → 442
      ZnF_Rad18; Rad18-like CCHC zinc finger
      COG5432
      Location:375 → 442
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
      cl19237
      Location:44 → 170
      DUF45; Protein of unknown function DUF45

    2. XM_006531020.5 → XP_006531083.1  DNA-dependent metalloprotease SPRTN isoform X2

      Conserved Domains (3) summary
      smart00734
      Location:375 → 398
      ZnF_Rad18; Rad18-like CCHC zinc finger
      smart00731
      Location:1 → 126
      SprT; SprT homologues
      COG5432
      Location:331 → 398
      RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

    RNA

    1. XR_387744.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G3X912.1 GenPept UniProtKB/Swiss-Prot:G3X912

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