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    Srrt serrate RNA effector molecule homolog (Arabidopsis) [ Mus musculus (house mouse) ]

    Gene ID: 83701, updated on 12-May-2024

    Summary

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    Official Symbol
    Srrtprovided by MGI
    Official Full Name
    serrate RNA effector molecule homolog (Arabidopsis)provided by MGI
    Primary source
    MGI:MGI:1933527
    See related
    Ensembl:ENSMUSG00000037364 AllianceGenome:MGI:1933527
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ars2; Asr2; ASR2A; ASR2B; ASR2C; ASR2D; 2810019G02Rik
    Summary
    Enables DNA binding activity. Involved in neuronal stem cell population maintenance; positive regulation of neurogenesis; and regulation of gene expression. Located in cytoplasm and nucleoplasm. Is expressed in several structures, including genitourinary system; liver; lung; retina; and spleen. Orthologous to human SRRT (serrate, RNA effector molecule). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 42.3), thymus adult (RPKM 37.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Srrt in Genome Data Viewer
    Location:
    5 G2; 5 76.33 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137293966..137306564, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137295704..137307716, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene acetylcholinesterase Neighboring gene microRNA 8116 Neighboring gene UFM1-specific peptidase 1 Neighboring gene microRNA 7036 Neighboring gene STARR-seq mESC enhancer starr_14639 Neighboring gene predicted gene 43013 Neighboring gene thyroid hormone receptor interactor 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ARS2 is required for retinal progenitor cell S-phase progression and Müller glial cell fate specification. O'Sullivan C, et al. Biochem Cell Biol, 2020 Feb. PMID 30673303
    2. Mutagenesis of ARS2 Domains To Assess Possible Roles in Cell Cycle Progression and MicroRNA and Replication-Dependent Histone mRNA Biogenesis. O'Sullivan C, et al. Mol Cell Biol, 2015 Nov. PMID 26303529, Free PMC Article
    3. ARS2 is a conserved eukaryotic gene essential for early mammalian development. Wilson MD, et al. Mol Cell Biol, 2008 Mar. PMID 18086880, Free PMC Article
    4. Long-lived microRNA-Argonaute complexes in quiescent cells can be activated to regulate mitogenic responses. Olejniczak SH, et al. Proc Natl Acad Sci U S A, 2013 Jan 2. PMID 23248281, Free PMC Article
    5. Ars2 maintains neural stem-cell identity through direct transcriptional activation of Sox2. Andreu-Agullo C, et al. Nature, 2011 Dec 25. PMID 22198669, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ars2 is an essential neural regulator that interacts dynamically with DNA and controls neural lineage development.
      Title: Regulation of embryonic and adult neurogenesis by Ars2.
    2. The Arsenic-resistance protein 2 (ARS2, also known as SRRT) is a component of the nuclear cap-binding complex involved in RNA Polymerase II transcription, and is required for cell cycle progression.
      Title: ARS2 is required for retinal progenitor cell S-phase progression and Müller glial cell fate specification.
    3. ARS2 plays a central role in RNA recognition and processing through multiple protein and RNA interactions.
      Title: Mutagenesis of ARS2 Domains To Assess Possible Roles in Cell Cycle Progression and MicroRNA and Replication-Dependent Histone mRNA Biogenesis.
    4. findings reveal Ars2 as a new transcription factor that controls the multipotent progenitor state of NSCs through direct activation of the pluripotency factor Sox2
      Title: Ars2 maintains neural stem-cell identity through direct transcriptional activation of Sox2.
    5. These findings provide evidence for a role for Ars2 in RNA interference regulation during cell proliferation.
      Title: Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation.
    6. These data indicate ARS2 is essential for early mammalian development and is likely involved in an essential cellular process.
      Title: ARS2 is a conserved eukaryotic gene essential for early mammalian development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA cap binding complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuronal stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in primary miRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in primary miRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in primary miRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serrate RNA effector molecule homolog
    Names
    arsenate resistance protein 2
    arsenite-resistance protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109909.1 → NP_001103379.1  serrate RNA effector molecule homolog isoform 2

      See identical proteins and their annotated locations for NP_001103379.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different acceptor splice site at the penultimate exon compared to transcript variant 1, resulting in a shorter isoform (2) missing a 7 aa segment, compared to isoform 1.
      Source sequence(s)
      AA986426, BC066831, CJ175065
      Consensus CDS
      CCDS80440.1
      UniProtKB/Swiss-Prot
      Q99MR6
      Related
      ENSMUSP00000143232.2, ENSMUST00000199243.5
      Conserved Domains (2) summary
      pfam04959
      Location:645 → 843
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:153 → 262
      DUF3546; Domain of unknown function (DUF3546)

    2. NM_001109910.1 → NP_001103380.1  serrate RNA effector molecule homolog isoform 3

      See identical proteins and their annotated locations for NP_001103380.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses different acceptor splice sites at the second and third to last exons compared to transcript variant 1, resulting in a shorter isoform (3) compared to isoform 1.
      Source sequence(s)
      AA986426, AK152710, BC066831, CJ175065
      Consensus CDS
      CCDS80439.1
      UniProtKB/Swiss-Prot
      Q99MR6
      Related
      ENSMUSP00000142564.2, ENSMUST00000197466.5
      Conserved Domains (2) summary
      pfam04959
      Location:645 → 839
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:153 → 262
      DUF3546; Domain of unknown function (DUF3546)

    3. NM_001359602.1 → NP_001346531.1  serrate RNA effector molecule homolog isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice junction in the 3' end compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC150682, AC243288
      Conserved Domains (2) summary
      pfam04959
      Location:645 → 846
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:153 → 262
      DUF3546; Domain of unknown function (DUF3546)

    4. NM_031405.2 → NP_113582.1  serrate RNA effector molecule homolog isoform 1

      See identical proteins and their annotated locations for NP_113582.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AA986426, BC066831, CB195376, CJ175065
      Consensus CDS
      CCDS39331.1
      UniProtKB/Swiss-Prot
      Q3UD04, Q5D042, Q8VEE6, Q99MR4, Q99MR5, Q99MR6, Q99MR7
      Conserved Domains (2) summary
      pfam04959
      Location:645 → 850
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:153 → 262
      DUF3546; Domain of unknown function (DUF3546)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      137293966..137306564 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254930.2 → XP_030110790.1  serrate RNA effector molecule homolog isoform X4

      Conserved Domains (2) summary
      pfam04959
      Location:418 → 612
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:1 → 35
      DUF3546; Domain of unknown function (DUF3546)

    2. XM_030254929.2 → XP_030110789.1  serrate RNA effector molecule homolog isoform X3

      Conserved Domains (2) summary
      pfam04959
      Location:418 → 623
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:1 → 35
      DUF3546; Domain of unknown function (DUF3546)

    3. XM_006504631.3 → XP_006504694.1  serrate RNA effector molecule homolog isoform X2

      Conserved Domains (2) summary
      pfam04959
      Location:480 → 685
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:32 → 97
      DUF3546; Domain of unknown function (DUF3546)

    4. XM_030254928.2 → XP_030110788.1  serrate RNA effector molecule homolog isoform X3

      Conserved Domains (2) summary
      pfam04959
      Location:418 → 623
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:1 → 35
      DUF3546; Domain of unknown function (DUF3546)

    5. XM_036165632.1 → XP_036021525.1  serrate RNA effector molecule homolog isoform X2

      Conserved Domains (2) summary
      pfam04959
      Location:480 → 685
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:32 → 97
      DUF3546; Domain of unknown function (DUF3546)

    6. XM_036165633.1 → XP_036021526.1  serrate RNA effector molecule homolog isoform X3

      Conserved Domains (2) summary
      pfam04959
      Location:418 → 623
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:1 → 35
      DUF3546; Domain of unknown function (DUF3546)

    7. XM_030254927.2 → XP_030110787.1  serrate RNA effector molecule homolog isoform X2

      Conserved Domains (2) summary
      pfam04959
      Location:480 → 685
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:32 → 97
      DUF3546; Domain of unknown function (DUF3546)

    8. XM_006504630.2 → XP_006504693.1  serrate RNA effector molecule homolog isoform X1

      See identical proteins and their annotated locations for XP_006504693.1

      Conserved Domains (2) summary
      pfam04959
      Location:548 → 753
      ARS2; Arsenite-resistance protein 2
      pfam12066
      Location:56 → 165
      DUF3546; Domain of unknown function (DUF3546)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99MR6.1 GenPept UniProtKB/Swiss-Prot:Q99MR6

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