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    LTO1 ABCE maturation factor [ Mus musculus (house mouse) ]

    Gene ID: 72284, updated on 3-Apr-2024

    Summary

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    Official Symbol
    LTO1provided by MGI
    Official Full Name
    ABCE maturation factorprovided by MGI
    Primary source
    MGI:MGI:1919534
    See related
    Ensembl:ENSMUSG00000031072 AllianceGenome:MGI:1919534
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TAOS1; Oraov1; 2210010N10Rik
    Summary
    Predicted to be involved in several processes, including protein maturation by [4Fe-4S] cluster transfer; telomere maintenance; and translational initiation. Predicted to be located in nucleus. Is expressed in cerebellum and rest of cerebellum mantle layer. Orthologous to human LTO1 (LTO1 maturation factor of ABCE1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 18.5), kidney adult (RPKM 17.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See LTO1 in Genome Data Viewer
    Location:
    7 F5; 7 88.92 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (144468882..144485989)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (144915100..144930748)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3764 Neighboring gene predicted gene, 39119 Neighboring gene STARR-positive B cell enhancer mm9_chr7:152123400-152123700 Neighboring gene brain cytoplasmic RNA 1 Neighboring gene cyclin D1 Neighboring gene STARR-seq mESC enhancer starr_20559 Neighboring gene STARR-seq mESC enhancer starr_20560 Neighboring gene predicted gene, 46023 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:152297325-152297512 Neighboring gene STARR-seq mESC enhancer starr_20563 Neighboring gene predicted gene 45181

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Neural BC1 RNA: cDNA clones reveal nonrepetitive sequence content. DeChiara TM, et al. Proc Natl Acad Sci U S A, 1987 May. PMID 2437583, Free PMC Article
    2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein maturation by [4Fe-4S] cluster transfer ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal large subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in telomere maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein LTO1 homolog
    Names
    oral cancer overexpressed 1
    oral cancer-overexpressed protein 1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347536.2 → NP_001334465.2  protein LTO1 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC161763
      Consensus CDS
      CCDS85485.1
      UniProtKB/TrEMBL
      D3Z5L0
      Related
      ENSMUSP00000101515.3, ENSMUST00000105895.2

    2. NM_001347537.2 → NP_001334466.2  protein LTO1 homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC161763
      Consensus CDS
      CCDS85486.1
      UniProtKB/TrEMBL
      F6SHW1
      Related
      ENSMUSP00000115840.3, ENSMUST00000128057.8

    3. NM_001357868.2 → NP_001344797.2  protein LTO1 homolog isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC161763

    4. NM_001357869.2 → NP_001344798.2  protein LTO1 homolog isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC161763

    5. NM_001361263.2 → NP_001348192.2  protein LTO1 homolog isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC161763

    6. NM_028184.5 → NP_082460.3  protein LTO1 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC161763
      Consensus CDS
      CCDS22054.1
      UniProtKB/Swiss-Prot
      Q8CH62, Q91YY7, Q922P0, Q9D7Y4
      Related
      ENSMUSP00000033388.7, ENSMUST00000033388.13

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      144468882..144485989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CH62.1 GenPept UniProtKB/Swiss-Prot:Q8CH62

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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