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    ZNF652 zinc finger protein 652 [ Homo sapiens (human) ]

    Gene ID: 22834, updated on 5-May-2024

    Summary

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    Official Symbol
    ZNF652provided by HGNC
    Official Full Name
    zinc finger protein 652provided by HGNC
    Primary source
    HGNC:HGNC:29147
    See related
    Ensembl:ENSG00000198740 MIM:613907; AllianceGenome:HGNC:29147
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in skin (RPKM 5.2), testis (RPKM 3.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF652 in Genome Data Viewer
    Location:
    17q21.32-q21.33
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (49288117..49362473, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (50152285..50225479, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (47366568..47439835, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904022 Neighboring gene uncharacterized FLJ40194 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8666 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:47338142-47338954 Neighboring gene microRNA 6129 Neighboring gene MPRA-validated peak2884 silencer Neighboring gene U7 small nuclear RNA Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8667 Neighboring gene MPRA-validated peak2885 silencer Neighboring gene MPRA-validated peak2886 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12359 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12360 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8668 Neighboring gene ZNF652 antisense RNA 1 Neighboring gene ribosomal protein L21 pseudogene 124 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12361 Neighboring gene prohibitin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ZNF652-Induced circRHOT1 Promotes SMAD5 Expression to Modulate Tumorigenic Properties and Nature Killer Cell-Mediated Toxicity in Bladder Cancer via Targeting miR-3666. Ke H, et al. J Immunol Res, 2021. PMID 34926705, Free PMC Article
    2. Fine-mapping the 2q37 and 17q11.2-q22 loci for novel genes and sequence variants associated with a genetic predisposition to prostate cancer. Laitinen VH, et al. Int J Cancer, 2015 May 15. PMID 25335771, Free PMC Article
    3. Genome-wide mapping of ZNF652 promoter binding sites in breast cancer cells. Kumar R, et al. J Cell Biochem, 2011 Oct. PMID 21678463
    4. Circular RNA circVRK1 suppresses the proliferation, migration and invasion of osteosarcoma cells by regulating zinc finger protein ZNF652 expression via microRNA miR-337-3p. Cheng C, et al. Bioengineered, 2021 Dec. PMID 34424826, Free PMC Article
    5. Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21. Haiman CA, et al. Nat Genet, 2011 Jun. PMID 21602798, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZNF652-Induced circRHOT1 Promotes SMAD5 Expression to Modulate Tumorigenic Properties and Nature Killer Cell-Mediated Toxicity in Bladder Cancer via Targeting miR-3666.
      Title: ZNF652-Induced circRHOT1 Promotes SMAD5 Expression to Modulate Tumorigenic Properties and Nature Killer Cell-Mediated Toxicity in Bladder Cancer via Targeting miR-3666.
    2. Circular RNA circVRK1 suppresses the proliferation, migration and invasion of osteosarcoma cells by regulating zinc finger protein ZNF652 expression via microRNA miR-337-3p.
      Title: Circular RNA circVRK1 suppresses the proliferation, migration and invasion of osteosarcoma cells by regulating zinc finger protein ZNF652 expression via microRNA miR-337-3p.
    3. Genetic association studies identify a novel variant in ZNF652 gene suggesting its role in prostate cancer.
      Title: Fine-mapping the 2q37 and 17q11.2-q22 loci for novel genes and sequence variants associated with a genetic predisposition to prostate cancer.
    4. De novo motif scanning of the ZNF652 binding sites identified a novel ZNF652 recognition motif that closely resembles the previously characterised in vitro binding site, being a 10 nucleotide core of that 13 nucleotide sequence.
      Title: Genome-wide mapping of ZNF652 promoter binding sites in breast cancer cells.
    5. Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
      Title: Discovery and replication of novel blood pressure genetic loci in the Women's Genome Health Study.
    6. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
      Title: Common variants in or near FGF5, CYP17A1 and MTHFR genes are associated with blood pressure and hypertension in Chinese Hans.
    7. variation in FGF5 and ZNF652 gene upstream regions with altered susceptibility to hypertension in Han Chinese
      Title: Confirmation of top polymorphisms in hypertension genome wide association study among Han Chinese.
    8. Observational study of gene-disease association. (HuGE Navigator)
      Title: Confirmation of top polymorphisms in hypertension genome wide association study among Han Chinese.
    9. High levels of expression of both the androgen receptor and ZNF652 in clinically organ-defined prostate cancer are associated with a statistically increased risk of relapse
      Title: Co-expression of the androgen receptor and the transcription factor ZNF652 is related to prostate cancer outcome.
    10. Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Genome-wide association study identifies eight loci associated with blood pressure.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
    EBI GWAS Catalog
    Genome-wide association study identifies eight loci associated with blood pressure.
    EBI GWAS Catalog
    Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
    EBI GWAS Catalog
    Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21.
    EBI GWAS Catalog
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    EBI GWAS Catalog
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0924, DKFZp781E2122

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 652

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145365.3 → NP_001138837.1  zinc finger protein 652

      See identical proteins and their annotated locations for NP_001138837.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC004797, AC091180, AK292667, BC152440, DN998934
      Consensus CDS
      CCDS32677.1
      UniProtKB/Swiss-Prot
      A4QPD9, Q5H9Q0, Q9Y2D9
      UniProtKB/TrEMBL
      A8K9F2
      Related
      ENSP00000416305.2, ENST00000430262.3
      Conserved Domains (4) summary
      COG5048
      Location:439 → 488
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:381 → 464
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:387 → 407
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl27293
      Location:240 → 304
      UFD1; Ubiquitin fusion degradation protein UFD1

    2. NM_014897.2 → NP_055712.1  zinc finger protein 652

      See identical proteins and their annotated locations for NP_055712.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC004797, BC152440
      Consensus CDS
      CCDS32677.1
      UniProtKB/Swiss-Prot
      A4QPD9, Q5H9Q0, Q9Y2D9
      UniProtKB/TrEMBL
      A8K9F2
      Related
      ENSP00000354686.2, ENST00000362063.6
      Conserved Domains (4) summary
      COG5048
      Location:439 → 488
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:381 → 464
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:387 → 407
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl27293
      Location:240 → 304
      UFD1; Ubiquitin fusion degradation protein UFD1

    RNA

    1. NR_135579.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC091180, BC034987, BF763222, BU838341, CN371383, DN998934

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      49288117..49362473 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047435629.1 → XP_047291585.1  zinc finger protein 652 isoform X2

      UniProtKB/TrEMBL
      D6RF85

    2. XM_047435628.1 → XP_047291584.1  zinc finger protein 652 isoform X2

      UniProtKB/TrEMBL
      D6RF85

    3. XM_047435626.1 → XP_047291582.1  zinc finger protein 652 isoform X1

      UniProtKB/Swiss-Prot
      A4QPD9, Q5H9Q0, Q9Y2D9

    4. XM_024450656.2 → XP_024306424.1  zinc finger protein 652 isoform X2

      UniProtKB/TrEMBL
      D6RF85
      Related
      ENSP00000424848.1, ENST00000508237.5

    5. XM_024450653.2 → XP_024306421.1  zinc finger protein 652 isoform X1

      UniProtKB/Swiss-Prot
      A4QPD9, Q5H9Q0, Q9Y2D9
      UniProtKB/TrEMBL
      A8K9F2
      Conserved Domains (4) summary
      COG5048
      Location:439 → 488
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:381 → 464
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:387 → 407
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl27293
      Location:240 → 304
      UFD1; Ubiquitin fusion degradation protein UFD1

    6. XM_047435627.1 → XP_047291583.1  zinc finger protein 652 isoform X1

      UniProtKB/Swiss-Prot
      A4QPD9, Q5H9Q0, Q9Y2D9

    7. XM_024450655.2 → XP_024306423.1  zinc finger protein 652 isoform X1

      UniProtKB/Swiss-Prot
      A4QPD9, Q5H9Q0, Q9Y2D9
      UniProtKB/TrEMBL
      A8K9F2
      Conserved Domains (4) summary
      COG5048
      Location:439 → 488
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:381 → 464
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:387 → 407
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl27293
      Location:240 → 304
      UFD1; Ubiquitin fusion degradation protein UFD1

    RNA

    1. XR_934423.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      50152285..50225479 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315490.1 → XP_054171465.1  zinc finger protein 652 isoform X2

      UniProtKB/TrEMBL
      D6RF85

    2. XM_054315489.1 → XP_054171464.1  zinc finger protein 652 isoform X2

      UniProtKB/TrEMBL
      D6RF85

    3. XM_054315484.1 → XP_054171459.1  zinc finger protein 652 isoform X1

      UniProtKB/Swiss-Prot
      A4QPD9, Q5H9Q0, Q9Y2D9

    4. XM_054315488.1 → XP_054171463.1  zinc finger protein 652 isoform X2

      UniProtKB/TrEMBL
      D6RF85

    5. XM_054315485.1 → XP_054171460.1  zinc finger protein 652 isoform X1

      UniProtKB/Swiss-Prot
      A4QPD9, Q5H9Q0, Q9Y2D9

    6. XM_054315486.1 → XP_054171461.1  zinc finger protein 652 isoform X1

      UniProtKB/Swiss-Prot
      A4QPD9, Q5H9Q0, Q9Y2D9

    7. XM_054315487.1 → XP_054171462.1  zinc finger protein 652 isoform X1

      UniProtKB/Swiss-Prot
      A4QPD9, Q5H9Q0, Q9Y2D9

    RNA

    1. XR_008484798.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y2D9.3 GenPept UniProtKB/Swiss-Prot:Q9Y2D9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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