U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif 5 [ Canis lupus familiaris (dog) ]

    Gene ID: 487713, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ADAMTS5provided by VGNC
    Official Full Name
    ADAM metallopeptidase with thrombospondin type 1 motif 5provided by VGNC
    Primary source
    VGNC:VGNC:37601
    See related
    Ensembl:ENSCAFG00845018095
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ADAMTS5 in Genome Data Viewer
    Location:
    chromosome: 31
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 31 NC_051835.1 (22341143..22388689, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 31 NC_006613.4 (22237302..22284778, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 31 NC_049252.1 (22794062..22841615, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 31 NC_049291.1 (22313499..22361201, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 31 NC_049772.1 (22319121..22366648, complement)

    Chromosome 31 - NC_051835.1Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 1 Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like Neighboring gene uncharacterized LOC106558103 Neighboring gene keratin, type I cytoskeletal 18-like

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    A disintegrin and metalloproteinase with thrombospondin motifs 5; LOW QUALITY PROTEIN: A disintegrin and metalloproteinase with thrombospondin motifs 5
    Names
    ADAM metallopeptidase with thrombospondin type 1 motif, 5 (aggrecanase-2)

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051835.1 Reference ROS_Cfam_1.0

      Range
      22341143..22388689 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038443286.1 → XP_038299214.1  A disintegrin and metalloproteinase with thrombospondin motifs 5

      UniProtKB/TrEMBL
      A0A8C0TFB3, A0A8I3P533, A0A8P0SDL0
      Related
      ENSCAFP00845025040.1, ENSCAFT00845032021.1
      Conserved Domains (6) summary
      smart00209
      Location:574 → 626
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:273 → 477
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam05986
      Location:736 → 856
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam01562
      Location:60 → 172
      Pep_M12B_propep; Reprolysin family propeptide
      pfam17771
      Location:491 → 558
      ADAM_CR_2; ADAM cysteine-rich domain
      pfam19030
      Location:883 → 934
      TSP1_ADAMTS; Thrombospondin type 1 domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049291.1 Alternate UMICH_Zoey_3.1

      Range
      22313499..22361201 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038517701.1 → XP_038373629.1  LOW QUALITY PROTEIN: A disintegrin and metalloproteinase with thrombospondin motifs 5

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049772.1 Alternate UNSW_CanFamBas_1.0

      Range
      22319121..22366648 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038645660.1 → XP_038501588.1  A disintegrin and metalloproteinase with thrombospondin motifs 5

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049252.1 Alternate UU_Cfam_GSD_1.0

      Range
      22794062..22841615 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038581284.1 → XP_038437212.1  A disintegrin and metalloproteinase with thrombospondin motifs 5

      UniProtKB/TrEMBL
      A0A8C0TFB3

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006613.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      22237302..22284778 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_846025.5 → XP_851118.3  A disintegrin and metalloproteinase with thrombospondin motifs 5

      UniProtKB/TrEMBL
      A0A8C0TFB3, A0A8I3P533, A0A8P0SDL0
      Conserved Domains (6) summary
      smart00209
      Location:574 → 626
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:273 → 477
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam05986
      Location:736 → 856
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam01562
      Location:60 → 172
      Pep_M12B_propep; Reprolysin family propeptide
      pfam17771
      Location:491 → 558
      ADAM_CR_2; ADAM cysteine-rich domain
      pfam19030
      Location:883 → 934
      TSP1_ADAMTS; Thrombospondin type 1 domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Miscellaneous