Psmb3 proteasome (prosome, macropain) subunit, beta type 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Psmb3provided by MGI
Official Full Name: proteasome (prosome, macropain) subunit, beta type 3provided by MGI
Primary source: MGI:MGI:1347014
See related: Ensembl:ENSMUSG00000069744 AllianceGenome:MGI:1347014
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C10-II
Summary: Predicted to enable endopeptidase activity. Predicted to be involved in proteasomal protein catabolic process. Predicted to act upstream of or within protein catabolic process. Part of proteasome core complex. Is expressed in several structures, including alimentary system; cranial ganglion; gonad; maturing glomerular tuft; and orbito-sphenoid. Orthologous to human PSMB3 (proteasome 20S subunit beta 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in large intestine adult (RPKM 174.6), kidney adult (RPKM 115.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 61.07 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (97594260..97604326)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (97703434..97713500)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

located within a 185-kb contig surrounding a transgene on chromosome 11
Title: Mutagenic transgene insertion into a region of high gene density and multiple linkage disruptions on mouse chromosome 11.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein catabolic process	TAS Traceable Author Statement more info	PubMed
involved_in proteolysis involved in protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
part_of proteasome complex	ISO Inferred from Sequence Orthology more info
part_of proteasome core complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome core complex	ISO Inferred from Sequence Orthology more info
part_of proteasome core complex, beta-subunit complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: proteasome subunit beta type-3

Names: proteasome chain 13; proteasome component C10-II; proteasome theta chain

NP_036101.1

EC 3.4.25.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011971.4 → NP_036101.1 proteasome subunit beta type-3

See identical proteins and their annotated locations for NP_036101.1

Status: PROVISIONAL

Source sequence(s)

AL596123

Consensus CDS

CCDS25328.1

UniProtKB/Swiss-Prot

Q9R1P1

UniProtKB/TrEMBL

Q545G0

Related

ENSMUSP00000099436.5, ENSMUST00000103147.5

Conserved Domains (1) summary

cd03759
Location:6 → 201

proteasome_beta_type_3; proteasome beta type-3 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...