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    Uqcc5 ubiquinol-cytochrome c reductase complex assembly factor 5 [ Mus musculus (house mouse) ]

    Gene ID: 66487, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Uqcc5provided by MGI
    Official Full Name
    ubiquinol-cytochrome c reductase complex assembly factor 5provided by MGI
    Primary source
    MGI:MGI:1913737
    See related
    Ensembl:ENSMUSG00000058351 AllianceGenome:MGI:1913737
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Smim4; Gm41122; 2010107H07Rik
    Summary
    Located in mitochondrion. Orthologous to human SMIM4 (small integral membrane protein 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 21.7), kidney adult (RPKM 18.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Uqcc5 in Genome Data Viewer
    Location:
    14; 14 B
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (30810081..30850894, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (31088127..31128930, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene ES cell cis-regulatory motif 1d Neighboring gene small nucleolar RNA, C/D box 19 Neighboring gene guanine nucleotide binding protein nucleolar 3 Neighboring gene polybromo 1 Neighboring gene predicted gene 5459 Neighboring gene STARR-positive B cell enhancer ABC_E934 Neighboring gene 5'-nucleotidase domain containing 2 Neighboring gene stabilin 1 Neighboring gene predicted gene, 52148

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial microproteins link metabolic cues to respiratory chain biogenesis. Liang C, et al. Cell Rep, 2022 Aug 16. PMID 35977508
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mitochondrial ribosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mitochondrial cytochrome c oxidase assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial respiratory chain complex III assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    ubiquinol-cytochrome c reductase complex assembly factor 5
    Names
    small integral membrane protein 4
    small nucleolar RNA host gene 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308091.2 → NP_001295020.1  ubiquinol-cytochrome c reductase complex assembly factor 5 isoform 2

      See identical proteins and their annotated locations for NP_001295020.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 3' terminal exon, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC154446
      Consensus CDS
      CCDS84105.1
      UniProtKB/Swiss-Prot
      Q8BZ92, Q8C1P1, Q8C1Q6
      Related
      ENSMUSP00000050634.6, ENSMUST00000049732.11
      Conserved Domains (1) summary
      pfam15114
      Location:4 → 68
      UPF0640; uncharacterized protein family UPF0640

    2. NM_001308464.2 → NP_001295393.1  ubiquinol-cytochrome c reductase complex assembly factor 5 isoform 1

      See identical proteins and their annotated locations for NP_001295393.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC154446
      Consensus CDS
      CCDS84104.1
      UniProtKB/Swiss-Prot
      Q8C1Q6
      Related
      ENSMUSP00000145018.2, ENSMUST00000203261.3
      Conserved Domains (1) summary
      pfam15114
      Location:4 → 50
      UPF0640; uncharacterized protein family UPF0640

    3. NM_001308466.2 → NP_001295395.1  ubiquinol-cytochrome c reductase complex assembly factor 5 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains two alternate internal exons, resulting in a distinct 3' coding region and a different 3' UTR, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC154446
      Consensus CDS
      CCDS84106.1
      UniProtKB/TrEMBL
      A0A0R3P9C4
      Related
      ENSMUSP00000067418.6, ENSMUST00000064032.10
      Conserved Domains (1) summary
      pfam15114
      Location:4 → 68
      UPF0640; uncharacterized protein family UPF0640

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      30810081..30850894 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C1Q6.2 GenPept UniProtKB/Swiss-Prot:Q8C1Q6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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