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    Haus1 HAUS augmin-like complex, subunit 1 [ Mus musculus (house mouse) ]

    Gene ID: 225745, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Haus1provided by MGI
    Official Full Name
    HAUS augmin-like complex, subunit 1provided by MGI
    Primary source
    MGI:MGI:2385076
    See related
    Ensembl:ENSMUSG00000041840 AllianceGenome:MGI:2385076
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ccdc5; HEI-C
    Summary
    Predicted to be involved in centrosome cycle and spindle assembly. Predicted to act upstream of or within cell division. Predicted to be located in centrosome and mitotic spindle microtubule. Predicted to be part of HAUS complex. Predicted to be active in cytosol. Is expressed in alimentary system; brain ventricular layer; chondrocranium; liver lobe; and renal cortex. Orthologous to human HAUS1 (HAUS augmin like complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 6.2), testis adult (RPKM 5.4) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Haus1 in Genome Data Viewer
    Location:
    18 E3; 18 52.38 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (77844977..77861602, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (77757277..77773885, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A330094K24 gene Neighboring gene RIKEN cDNA 5730552O08 gene Neighboring gene STARR-seq mESC enhancer starr_45128 Neighboring gene STARR-positive B cell enhancer ABC_E4255 Neighboring gene STARR-seq mESC enhancer starr_45130 Neighboring gene predicted gene, 52331 Neighboring gene STARR-seq mESC enhancer starr_45133 Neighboring gene RIKEN cDNA F830208F22 gene Neighboring gene ATP synthase F1 subunit alpha Neighboring gene STARR-positive B cell enhancer mm9_chr18:78030749-78031049 Neighboring gene proline-serine-threonine phosphatase-interacting protein 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:78061325-78061621 Neighboring gene STARR-positive B cell enhancer ABC_E2514 Neighboring gene ectopic P-granules 5 autophagy tethering factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TRIM8 interacts with KIF11 and KIFC1 and controls bipolar spindle formation and chromosomal stability. Venuto S, et al. Cancer Lett, 2020 Mar 31. PMID 31904480
    2. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    3. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068, Free PMC Article
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Hein MY, et al. Cell, 2015 Oct 22. PMID 26496610

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC36238

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centrosome cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centrosome cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of HAUS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of HAUS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    HAUS augmin-like complex subunit 1
    Names
    coiled-coil domain-containing protein 5
    spindle associated

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357531.1 → NP_001344460.1  HAUS augmin-like complex subunit 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC162291
      Consensus CDS
      CCDS89282.1
      UniProtKB/TrEMBL
      A0A494BB26
      Conserved Domains (1) summary
      COG1196
      Location:52 → 286
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. NM_001357532.1 → NP_001344461.1  HAUS augmin-like complex subunit 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC162291
      Consensus CDS
      CCDS89282.1
      UniProtKB/TrEMBL
      A0A494BB26
      Related
      ENSMUSP00000158336.2, ENSMUST00000236234.2
      Conserved Domains (1) summary
      COG1196
      Location:52 → 286
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. NM_001357533.1 → NP_001344462.1  HAUS augmin-like complex subunit 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC162291
      Consensus CDS
      CCDS89282.1
      UniProtKB/TrEMBL
      A0A494BB26
      Conserved Domains (1) summary
      COG1196
      Location:52 → 286
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    4. NM_146089.3 → NP_666201.1  HAUS augmin-like complex subunit 1 isoform 1

      See identical proteins and their annotated locations for NP_666201.1

      Status: VALIDATED

      Source sequence(s)
      AC162291, AK146923, BY106914, CD545676
      Consensus CDS
      CCDS29357.1
      UniProtKB/Swiss-Prot
      Q3UIH2, Q8BHX1, Q8R1M1
      Related
      ENSMUSP00000035826.8, ENSMUST00000048192.9
      Conserved Domains (1) summary
      COG1196
      Location:37 → 271
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      77844977..77861602 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161131.1 → XP_036017024.1  HAUS augmin-like complex subunit 1 isoform X2

      Conserved Domains (1) summary
      COG1196
      Location:43 → 195
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. XM_036161132.1 → XP_036017025.1  HAUS augmin-like complex subunit 1 isoform X2

      Conserved Domains (1) summary
      COG1196
      Location:43 → 195
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. XM_036161130.1 → XP_036017023.1  HAUS augmin-like complex subunit 1 isoform X1

      UniProtKB/TrEMBL
      A0A494BB26
      Conserved Domains (1) summary
      COG1196
      Location:52 → 286
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    4. XM_030250449.2 → XP_030106309.1  HAUS augmin-like complex subunit 1 isoform X1

      UniProtKB/TrEMBL
      A0A494BB26
      Conserved Domains (1) summary
      COG1196
      Location:52 → 286
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    5. XM_036161133.1 → XP_036017026.1  HAUS augmin-like complex subunit 1 isoform X2

      Conserved Domains (1) summary
      COG1196
      Location:43 → 195
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RNA

    1. XR_004939849.1 RNA Sequence

    2. XR_004939848.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BHX1.2 GenPept UniProtKB/Swiss-Prot:Q8BHX1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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