Rem1 rad and gem related GTP binding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rem1provided by MGI
Official Full Name: rad and gem related GTP binding protein 1provided by MGI
Primary source: MGI:MGI:1097696
See related: Ensembl:ENSMUSG00000000359 AllianceGenome:MGI:1097696
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ras; Rem; E030011C07Rik
Summary: Predicted to enable GTP binding activity and calcium channel regulator activity. Predicted to be involved in negative regulation of high voltage-gated calcium channel activity and signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in alimentary system and urinary system. Orthologous to human REM1 (RRAD and GEM like GTPase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in genital fat pad adult (RPKM 15.2), ovary adult (RPKM 10.6) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H1; 2 75.41 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (152468928..152477111)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (152627008..152635191)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results reveal that similar molecular determinants on Rem are repurposed to initiate 2 independent mechanisms of CaV1.2 inhibition.
Title: Similar molecular determinants on Rem mediate two distinct modes of inhibition of Ca(V)1.2 channels.
Rad, Gem and Rem all reduce depolarization-dependent Ca2+ entry in developing myotubes.
Title: RGK protein-mediated impairment of slow depolarization- dependent Ca2+ entry into developing myotubes.
amino-termini of Rad and Rem as the structural elements dictating the specific modes of inhibition of CaV1.1
Title: Differential effects of RGK proteins on L-type channel function in adult mouse skeletal muscle.
Loss of an REM1 protein increased L-type calcium current density in vivo in cardiac myocytes.
Title: Rem-GTPase regulates cardiac myocyte L-type calcium current.
Nuclear localization of RGK proteins (Rad, Rem, and Rem2) contributes to the suppression of RGK-mediated cell shape remodeling.
Title: Nuclear localization of endogenous RGK proteins and modulation of cell shape remodeling by regulated nuclear transport.
a role for the Rem C terminus in plasma membrane localization through association with phosphatidylinositol lipids.
Title: Plasma membrane targeting is essential for Rem-mediated Ca2+ channel inhibition.
both Rem and Rad bind directly to Ca2+ channel beta-subunits (CaV beta) in vivo
Title: Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases.
We conclude that Rem is capable of regulating L-type current, that release of Rem block is modulated by cellular kinase pathways, and that the Ca(V)1.2 COOH terminus contributes to Rem-dependent channel inhibition.
Title: L-type calcium channel alpha-subunit and protein kinase inhibitors modulate Rem-mediated regulation of current.
Rem-dependent Ca2+ channel modulation involves formation of a Rem x CaVbeta x alpha-interaction domain regulatory complex without the need to disrupt CaValpha1 x CaVbeta association or alter CaValpha1 expression at the plasma membrane.
Title: Analysis of the complex between Ca2+ channel beta-subunit and the Rem GTPase.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:493675

RH91899 (e-PCR)
- UniSTS:91776

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables calcium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of high voltage-gated calcium channel activity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of skeletal muscle contraction by calcium ion signaling	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in I band	IDA Inferred from Direct Assay more info	PubMed
located_in T-tubule	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: GTP-binding protein REM 1

Names: RAS-like GTP binding protein Rem; rad and Gem-like GTP-binding protein 1

NP_033073.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009047.5 → NP_033073.1 GTP-binding protein REM 1

See identical proteins and their annotated locations for NP_033073.1

Status: PROVISIONAL

Source sequence(s)

AK053133

Consensus CDS

CCDS16895.1

UniProtKB/Swiss-Prot

O35929

UniProtKB/TrEMBL

B2RWZ4

Related

ENSMUSP00000000369.4, ENSMUST00000000369.4

Conserved Domains (2) summary

smart00010
Location:81 → 245

small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily

cd04148
Location:81 → 297

RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases