Ptk7 PTK7 protein tyrosine kinase 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptk7provided by MGI
Official Full Name: PTK7 protein tyrosine kinase 7provided by MGI
Primary source: MGI:MGI:1918711
See related: Ensembl:ENSMUSG00000023972 AllianceGenome:MGI:1918711
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: chz; mPTK7/CCK4; 8430404F20Rik
Summary: Predicted to enable cell adhesion molecule binding activity. Acts upstream of or within several processes, including animal organ development; axis elongation; and morphogenesis of an epithelium. Located in cell-cell junction and plasma membrane. Is expressed in several structures, including alimentary system; nervous system; paraxial mesenchyme; reproductive system; and sensory organ. Orthologous to human PTK7 (protein tyrosine kinase 7 (inactive)). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in limb E14.5 (RPKM 30.4), ovary adult (RPKM 29.7) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 C; 17 22.9 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (46875377..46940975, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (46564451..46630049, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling.
Title: Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling.
Protein Tyrosine Kinase 7 (PTK7) Promotes Metastasis in Hepatocellular Carcinoma via SOX9 Regulation and TGF-beta Signaling.
Title: Protein Tyrosine Kinase 7 (PTK7) Promotes Metastasis in Hepatocellular Carcinoma via SOX9 Regulation and TGF-β Signaling.
PTK7 regulates extracellular matrix integrity and the activity levels of RAC1 and myosin II, which in turn regulates Wolffian duct morphogenesis and therefore, epididymal function.
Title: Protein tyrosine kinase 7 regulates extracellular matrix integrity and mesenchymal intracellular RAC1 and myosin II activities during Wolffian duct morphogenesis.
In a Ptk7-deficient mouse strain, loss of Ptk7 leads to a diminished pool of hematopoietic stem cells but does not affect in vitro or in vivo differentiation. This is correlated with increased quiescence and reduced homing abilities of Ptk7-deficient hematopoietic stem and progenitor cells.
Title: Ptk7-Deficient Mice Have Decreased Hematopoietic Stem Cell Pools as a Result of Deregulated Proliferation and Migration.
Data suggest that protein tyrosine kinase 7 (PTK7) is essential for Wolffian duct morphogenesis and male fertility.
Title: Protein tyrosine kinase 7 is essential for tubular morphogenesis of the Wolffian duct.
data demonstrates that PTK7 regulates the activity of KDR biphasically by inducing oligomerization of KDR molecules at lower concentrations and by surrounding KDR molecules at higher concentrations.
Title: Biphasic effect of PTK7 on KDR activity in endothelial cells and angiogenesis.
PTK7 expression plays an important role in the invasiveness of intrahepatic cholangiocarcinoma cells.
Title: High expression of protein tyrosine kinase 7 significantly associates with invasiveness and poor prognosis in intrahepatic cholangiocarcinoma.
Planar polarity of neural cell motility and intercalation requires Ptk7 function.
Title: Distinct apical and basolateral mechanisms drive planar cell polarity-dependent convergent extension of the mouse neural plate.
acts in conjunction with the noncanonical Wnt pathway to orient epithelial planar cell polarity through modulation of myosin II-based contractile tension between supporting cells and hair cells
Title: PTK7 regulates myosin II activity to orient planar polarity in the mammalian auditory epithelium.
The tyrosine kinase receptor, PTK7, is implicated in beta-catenin-dependent developmental processes.
Title: PTK7: a cell polarity receptor with multiple facets.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (1)
Gene trapped (2) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

mHAa31e2.seq (e-PCR)
- UniSTS:125970

AW146303 (e-PCR)
- UniSTS:181022

NoName (e-PCR)
- UniSTS:237657

D1S3693 (e-PCR)
- UniSTS:474271

AW821968 (e-PCR)
- UniSTS:209316

RH125764 (e-PCR)
- UniSTS:162515

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
NOT enables ATP binding	IC Inferred by Curator more info	PubMed
NOT enables kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
NOT enables transmembrane receptor protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axis elongation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cellular response to retinoic acid	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cochlea morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within convergent extension	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within coronary vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of epithelial cell apical/basal polarity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung-associated mesenchyme development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural tube closure	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neural tube closure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within planar cell polarity pathway involved in neural tube closure	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within ventricular septum development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within wound healing	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: inactive tyrosine-protein kinase 7

Names: protein chuzhoi; protein-tyrosine kinase 7; pseudo tyrosine kinase receptor 7; receptor tyrosine kinase-like protein; tyrosine-protein kinase-like 7

NP_780377.1

EC 2.7.10.1

XP_006524985.2

EC 2.7.10.1

XP_006524986.1

EC 2.7.10.1

XP_006524987.1

EC 2.7.10.1

XP_017173127.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175168.4 → NP_780377.1 inactive tyrosine-protein kinase 7 precursor

See identical proteins and their annotated locations for NP_780377.1

Status: VALIDATED

Source sequence(s)

AK053044, BC076578

Consensus CDS

CCDS37637.1

UniProtKB/Swiss-Prot

Q3V422, Q6W8S9, Q8BKG3, Q8CHK5, Q8K178

Related

ENSMUSP00000043703.9, ENSMUST00000044442.10

Conserved Domains (8) summary

cd05046
Location:782 → 1055

PTK_CCK4; Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4

cd05760
Location:138 → 214

Ig2_PTK7; Second immunoglobulin (Ig)-like domain of protein tyrosine kinase (PTK) 7, also known as CCK4

smart00219
Location:793 → 1053

TyrKc; Tyrosine kinase, catalytic domain

smart00408
Location:597 → 661

IGc2; Immunoglobulin C-2 Type

smart00409
Location:30 → 98

IG; Immunoglobulin

smart00410
Location:590 → 673

IG_like; Immunoglobulin like

pfam07679
Location:404 → 490

I-set; Immunoglobulin I-set domain

cl11960
Location:406 → 490

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

46875377..46940975 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524924.2 → XP_006524987.1 inactive tyrosine-protein kinase 7 isoform X3

Conserved Domains (6) summary

cd05046
Location:768 → 1041

PTK_CCK4; Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4

cd05760
Location:124 → 200

Ig2_PTK7; Second immunoglobulin (Ig)-like domain of protein tyrosine kinase (PTK) 7, also known as CCK4

smart00408
Location:314 → 376

IGc2; Immunoglobulin C-2 Type

cd00096
Location:587 → 647

Ig; Immunoglobulin domain

pfam13927
Location:205 → 280

Ig_3; Immunoglobulin domain

cl11960
Location:390 → 476

Ig; Immunoglobulin domain
XM_017317638.1 → XP_017173127.1 inactive tyrosine-protein kinase 7 isoform X4

Conserved Domains (5) summary

cd05046
Location:548 → 821

PTK_CCK4; Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4

smart00408
Location:94 → 156

IGc2; Immunoglobulin C-2 Type

cd00096
Location:367 → 427

Ig; Immunoglobulin domain

pfam13927
Location:2 → 60

Ig_3; Immunoglobulin domain

cl11960
Location:170 → 256

Ig; Immunoglobulin domain
XM_006524922.2 → XP_006524985.2 inactive tyrosine-protein kinase 7 isoform X1

Conserved Domains (6) summary

cd05046
Location:788 → 1061

PTK_CCK4; Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4

cd05760
Location:144 → 220

Ig2_PTK7; Second immunoglobulin (Ig)-like domain of protein tyrosine kinase (PTK) 7, also known as CCK4

smart00408
Location:334 → 396

IGc2; Immunoglobulin C-2 Type

cd00096
Location:607 → 667

Ig; Immunoglobulin domain

pfam13927
Location:225 → 300

Ig_3; Immunoglobulin domain

cl11960
Location:410 → 496

Ig; Immunoglobulin domain
XM_006524923.1 → XP_006524986.1 inactive tyrosine-protein kinase 7 isoform X2

Conserved Domains (6) summary

cd05046
Location:808 → 1081

PTK_CCK4; Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4

cd05760
Location:164 → 240

Ig2_PTK7; Second immunoglobulin (Ig)-like domain of protein tyrosine kinase (PTK) 7, also known as CCK4

smart00408
Location:354 → 416

IGc2; Immunoglobulin C-2 Type

cd00096
Location:627 → 687

Ig; Immunoglobulin domain

pfam13927
Location:245 → 320

Ig_3; Immunoglobulin domain

cl11960
Location:430 → 516

Ig; Immunoglobulin domain