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    Mrpl44 mitochondrial ribosomal protein L44 [ Mus musculus (house mouse) ]

    Gene ID: 69163, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Mrpl44provided by MGI
    Official Full Name
    mitochondrial ribosomal protein L44provided by MGI
    Primary source
    MGI:MGI:1916413
    See related
    Ensembl:ENSMUSG00000026248 AllianceGenome:MGI:1916413
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810030E18Rik; 5730593H20Rik
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translational elongation. Predicted to be located in nuclear body and plasma membrane. Predicted to be part of mitochondrial large ribosomal subunit. Predicted to be active in mitochondrion. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; sensory organ; and spleen. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 16. Orthologous to human MRPL44 (mitochondrial ribosomal protein L44). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 10.3), heart adult (RPKM 9.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mrpl44 in Genome Data Viewer
    Location:
    1 C4; 1 40.96 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (79753735..79759162)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (79776018..79781445)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_01444 Neighboring gene predicted gene, 24160 Neighboring gene STARR-seq mESC enhancer starr_01445 Neighboring gene STARR-seq mESC enhancer starr_01446 Neighboring gene adaptor-related protein complex AP-1, sigma 3 Neighboring gene STARR-positive B cell enhancer ABC_E10017 Neighboring gene STARR-positive B cell enhancer ABC_E3283 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:79707879-79708032 Neighboring gene WD repeat and FYVE domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_01447 Neighboring gene STARR-positive B cell enhancer ABC_E4328 Neighboring gene STARR-positive B cell enhancer mm9_chr1:79772314-79772614 Neighboring gene predicted gene, 39666 Neighboring gene serine (or cysteine) peptidase inhibitor, clade E, member 2 Neighboring gene STARR-seq mESC enhancer starr_01448 Neighboring gene STARR-seq mESC enhancer starr_01449

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice. Richman TR, et al. Nat Commun, 2016 Jun 20. PMID 27319982, Free PMC Article
    2. DDX1 vesicles control calcium-dependent mitochondrial activity in mouse embryos. Wang Y, et al. Nat Commun, 2022 Jul 1. PMID 35778392, Free PMC Article
    3. Nuclear-encoded mitochondrial ribosomal proteins are required to initiate gastrulation. Cheong A, et al. Development, 2020 May 26. PMID 32376682, Free PMC Article
    4. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article
    5. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribonuclease III activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitochondrial translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial translational elongation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of microprocessor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of mitochondrial large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial large ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein mL44
    Names
    39S ribosomal protein L44, mitochondrial
    L44mt
    MRP-L44
    NP_001074679.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081210.1 → NP_001074679.1  large ribosomal subunit protein mL44 precursor

      See identical proteins and their annotated locations for NP_001074679.1

      Status: PROVISIONAL

      Source sequence(s)
      AC170750
      Consensus CDS
      CCDS35629.1
      UniProtKB/Swiss-Prot
      Q3U0J0, Q8VE61, Q9CY73
      UniProtKB/TrEMBL
      Q3UKG1
      Related
      ENSMUSP00000027464.9, ENSMUST00000027464.9
      Conserved Domains (2) summary
      COG0571
      Location:77 → 305
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cl00054
      Location:236 → 304
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      79753735..79759162
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_026970.1: Suppressed sequence

      Description
      NM_026970.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CY73.3 GenPept UniProtKB/Swiss-Prot:Q9CY73

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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