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    Lmtk3 lemur tyrosine kinase 3 [ Mus musculus (house mouse) ]

    Gene ID: 381983, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Lmtk3provided by MGI
    Official Full Name
    lemur tyrosine kinase 3provided by MGI
    Primary source
    MGI:MGI:3039582
    See related
    Ensembl:ENSMUSG00000062044 AllianceGenome:MGI:3039582
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    aatyk3
    Summary
    Predicted to enable protein kinase activity. Predicted to be involved in protein phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in Golgi apparatus; cell projection; and membrane. Predicted to be integral component of membrane. Is expressed in liver lobe and nervous system. Orthologous to human LMTK3 (lemur tyrosine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in whole brain E14.5 (RPKM 35.4), CNS E14 (RPKM 29.4) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lmtk3 in Genome Data Viewer
    Location:
    7 B3; 7 29.5 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45432577..45456315)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45783134..45804144)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene sulfotransferase family, cytosolic, 2B, member 1 Neighboring gene STARR-seq mESC enhancer starr_18855 Neighboring gene predicted gene, 31597 Neighboring gene predicted gene, 39009 Neighboring gene predicted gene 5897 Neighboring gene STARR-positive B cell enhancer ABC_E6546 Neighboring gene STARR-positive B cell enhancer ABC_E8838 Neighboring gene STARR-positive B cell enhancer ABC_E549 Neighboring gene cytohesin 2 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 14 Neighboring gene glutamate-rich WD repeat containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Lmtk3-KO Mice Display a Range of Behavioral Abnormalities and Have an Impairment in GluA1 Trafficking. Montrose K, et al. Neuroscience, 2019 Aug 21. PMID 31310731
    2. LMTK3 deficiency causes pronounced locomotor hyperactivity and impairs endocytic trafficking. Inoue T, et al. J Neurosci, 2014 Apr 23. PMID 24760852, Free PMC Article
    3. Structural and functional analysis of the apoptosis-associated tyrosine kinase (AATYK) family. Tomomura M, et al. Neuroscience, 2007 Aug 24. PMID 17651901
    4. Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Trinidad JC, et al. Mol Cell Proteomics, 2006 May. PMID 16452087
    5. Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Munton RP, et al. Mol Cell Proteomics, 2007 Feb. PMID 17114649

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Behavioral analysis of Lmtk3-KO mice revealed a number of abnormalities that have been linked to psychiatric disease such as hyper-sociability, PPI deficits and cognitive dysfunction. Further investigation revealed abnormalities in GluA1 trafficking after AMPA stimulation in Lmtk3-KO neurons, along with a reduction in GluA1 expression in the post-synaptic density.
      Title: Lmtk3-KO Mice Display a Range of Behavioral Abnormalities and Have an Impairment in GluA1 Trafficking.
    2. the dopamine metabolite levels and dopamine turnover rate are increased in the striata of Lmtk3(-/-) mice compared with controls. In addition, we found that LMTK3 is involved in the endocytic trafficking of N-methyl-d-aspartate receptors.
      Title: LMTK3 deficiency causes pronounced locomotor hyperactivity and impairs endocytic trafficking.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC90743

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase LMTK3
    Names
    apoptosis-associated tyrosine kinase 3
    NP_001005511.2
    NP_001277919.1
    XP_006541027.1
    XP_017177816.1
    XP_030098591.1
    XP_030098592.1
    XP_030098593.1
    XP_030098594.1
    XP_030098595.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005511.4 → NP_001005511.2  serine/threonine-protein kinase LMTK3 precursor

      See identical proteins and their annotated locations for NP_001005511.2

      Status: VALIDATED

      Source sequence(s)
      AC149053, AC167242
      Consensus CDS
      CCDS39961.1
      UniProtKB/Swiss-Prot
      A6BLZ0, Q52KF1, Q5XJV6
      UniProtKB/TrEMBL
      A0A0R4J0W7
      Related
      ENSMUSP00000072388.6, ENSMUST00000072580.12
      Conserved Domains (1) summary
      cl21453
      Location:135 → 410
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001290990.2 → NP_001277919.1  serine/threonine-protein kinase LMTK3 precursor

      See identical proteins and their annotated locations for NP_001277919.1

      Status: VALIDATED

      Source sequence(s)
      AC149053, AC167242
      Consensus CDS
      CCDS39961.1
      UniProtKB/Swiss-Prot
      A6BLZ0, Q52KF1, Q5XJV6
      UniProtKB/TrEMBL
      A0A0R4J0W7
      Related
      ENSMUSP00000112592.2, ENSMUST00000120005.10
      Conserved Domains (1) summary
      cl21453
      Location:135 → 410
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. NR_110987.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC149053, AC167242

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      45432577..45456315
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017322327.3 → XP_017177816.1  serine/threonine-protein kinase LMTK3 isoform X2

      UniProtKB/Swiss-Prot
      A6BLZ0, Q52KF1, Q5XJV6
      UniProtKB/TrEMBL
      A0A0R4J0W7
      Conserved Domains (1) summary
      cl21453
      Location:135 → 410
      PKc_like; Protein Kinases, catalytic domain

    2. XM_030242731.2 → XP_030098591.1  serine/threonine-protein kinase LMTK3 isoform X1

      UniProtKB/TrEMBL
      A0A1B0GSR5
      Conserved Domains (1) summary
      cl21453
      Location:162 → 437
      PKc_like; Protein Kinases, catalytic domain

    3. XM_030242732.2 → XP_030098592.1  serine/threonine-protein kinase LMTK3 isoform X3

      UniProtKB/Swiss-Prot
      A6BLZ0, Q52KF1, Q5XJV6
      Conserved Domains (1) summary
      cl21453
      Location:24 → 299
      PKc_like; Protein Kinases, catalytic domain

    4. XM_030242734.2 → XP_030098594.1  serine/threonine-protein kinase LMTK3 isoform X4

      UniProtKB/Swiss-Prot
      A6BLZ0, Q52KF1, Q5XJV6
      Conserved Domains (1) summary
      cl21453
      Location:1 → 201
      PKc_like; Protein Kinases, catalytic domain

    5. XM_030242735.2 → XP_030098595.1  serine/threonine-protein kinase LMTK3 isoform X5

      UniProtKB/Swiss-Prot
      A6BLZ0, Q52KF1, Q5XJV6
      Conserved Domains (1) summary
      cl21453
      Location:34 → 179
      PKc_like; Protein Kinases, catalytic domain

    6. XM_006540964.5 → XP_006541027.1  serine/threonine-protein kinase LMTK3 isoform X2

      See identical proteins and their annotated locations for XP_006541027.1

      UniProtKB/Swiss-Prot
      A6BLZ0, Q52KF1, Q5XJV6
      UniProtKB/TrEMBL
      A0A0R4J0W7
      Conserved Domains (1) summary
      cl21453
      Location:135 → 410
      PKc_like; Protein Kinases, catalytic domain

    7. XM_030242733.2 → XP_030098593.1  serine/threonine-protein kinase LMTK3 isoform X4

      UniProtKB/Swiss-Prot
      A6BLZ0, Q52KF1, Q5XJV6
      Conserved Domains (1) summary
      cl21453
      Location:1 → 201
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_004934123.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XJV6.1 GenPept UniProtKB/Swiss-Prot:Q5XJV6

    Gene LinkOut

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