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    Pof1b POF1B, actin binding protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302328, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Pof1bprovided by RGD
    Official Full Name
    POF1B, actin binding proteinprovided by RGD
    Primary source
    RGD:1560798
    See related
    Ensembl:ENSRNOG00000004795 AllianceGenome:RGD:1560798
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560798
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization; bicellular tight junction assembly; and epithelial cell morphogenesis. Predicted to be located in desmosome. Predicted to be active in actin filament; adherens junction; and bicellular tight junction. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 2B. Orthologous to human POF1B (POF1B actin binding protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 59.7), Uterus (RPKM 8.8) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pof1b in Genome Data Viewer
    Location:
    Xq31
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (81875348..81942046, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (77683128..77749827, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (84099618..84167717, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2010106E10 gene like Neighboring gene zinc finger protein 711 Neighboring gene replication factor C subunit 4, pseudogene 1 Neighboring gene uncharacterized LOC134484037 Neighboring gene lactate dehydrogenase A, pseudogene 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The POF1B candidate gene for premature ovarian failure regulates epithelial polarity. Padovano V, et al. J Cell Sci, 2011 Oct 1. PMID 21940798
    2. Disruption of POF1B binding to nonmuscle actin filaments is associated with premature ovarian failure. Lacombe A, et al. Am J Hum Genet, 2006 Jul. PMID 16773570, Free PMC Article
    3. Isolation of mammalian 26S proteasomes and p97/VCP complexes using the ubiquitin-like domain from HHR23B reveals novel proteasome-associated proteins. Besche HC, et al. Biochemistry, 2009 Mar 24. PMID 19182904, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in bicellular tight junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in bicellular tight junction assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in epithelial cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin filament ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in bicellular tight junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in desmosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein POF1B
    Names
    premature ovarian failure 1B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106934.1 → NP_001100404.1  protein POF1B

      See identical proteins and their annotated locations for NP_001100404.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473969
      UniProtKB/TrEMBL
      A6IVA4, D3ZWE3
      Related
      ENSRNOP00000006415.5, ENSRNOT00000006415.6
      Conserved Domains (1) summary
      cl24005
      Location:337 → 435
      DUF2570; Protein of unknown function (DUF2570)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      81875348..81942046 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279892.1 → XP_063135962.1  protein POF1B isoform X2

      UniProtKB/TrEMBL
      A6IVA4, D3ZWE3

    2. XM_039099585.2 → XP_038955513.1  protein POF1B isoform X1

      Conserved Domains (1) summary
      TIGR02169
      Location:273 → 529
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    Nucleotide Protein Strain
    Heading Accession and Version

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