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    Phospho2 phosphatase, orphan 2 [ Mus musculus (house mouse) ]

    Gene ID: 73373, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Phospho2provided by MGI
    Official Full Name
    phosphatase, orphan 2provided by MGI
    Primary source
    MGI:MGI:1920623
    See related
    Ensembl:ENSMUSG00000027088 AllianceGenome:MGI:1920623
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Phos2; 1700048E23Rik
    Summary
    Predicted to enable phosphatase activity. Orthologous to human PHOSPHO2 (phosphatase, orphan 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 58.1), adrenal adult (RPKM 8.9) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Phospho2 in Genome Data Viewer
    Location:
    2 C2; 2 40.95 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (69620081..69627567)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (69789605..69797223)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10110 Neighboring gene peptidyl-prolyl isomerase G (cyclophilin G) Neighboring gene STARR-positive B cell enhancer mm9_chr2:69582878-69583179 Neighboring gene 60S ribosomal protein L13-like Neighboring gene cilia and flagella associated protein 210 Neighboring gene STARR-seq mESC enhancer starr_04744 Neighboring gene STARR-positive B cell enhancer ABC_E4461 Neighboring gene predicted gene 13624 Neighboring gene predicted gene, 39841

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Probing the substrate specificities of human PHOSPHO1 and PHOSPHO2. Roberts SJ, et al. Biochim Biophys Acta, 2005 Aug 31. PMID 16054448
    2. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyridoxal phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    pyridoxal phosphate phosphatase PHOSPHO2
    NP_082797.1
    XP_006500320.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028521.2 → NP_082797.1  pyridoxal phosphate phosphatase PHOSPHO2

      See identical proteins and their annotated locations for NP_082797.1

      Status: PROVISIONAL

      Source sequence(s)
      AK006724
      Consensus CDS
      CCDS16099.1
      UniProtKB/Swiss-Prot
      A2AR04, Q3V1M5, Q9D9M5
      Related
      ENSMUSP00000028494.3, ENSMUST00000028494.9
      Conserved Domains (1) summary
      pfam06888
      Location:3 → 239
      Put_Phosphatase; Putative Phosphatase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      69620081..69627567
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500257.3 → XP_006500320.1  pyridoxal phosphate phosphatase PHOSPHO2 isoform X1

      See identical proteins and their annotated locations for XP_006500320.1

      UniProtKB/Swiss-Prot
      A2AR04, Q3V1M5, Q9D9M5
      Related
      ENSMUSP00000136471.2, ENSMUST00000180290.2
      Conserved Domains (1) summary
      pfam06888
      Location:3 → 239
      Put_Phosphatase; Putative Phosphatase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D9M5.1 GenPept UniProtKB/Swiss-Prot:Q9D9M5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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