Zfp366 zinc finger protein 366 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp366provided by MGI
Official Full Name: zinc finger protein 366provided by MGI
Primary source: MGI:MGI:2178429
See related: Ensembl:ENSMUSG00000050919 AllianceGenome:MGI:2178429
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Znf366; DC-SCRIPT
Summary: Predicted to enable several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; estrogen receptor binding activity; and transcription corepressor activity. Predicted to be involved in negative regulation of intracellular estrogen receptor signaling pathway; negative regulation of transcription by RNA polymerase II; and response to estrogen. Located in nucleus. Used to study DiGeorge syndrome. Orthologous to human ZNF366 (zinc finger protein 366). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in lung adult (RPKM 7.2), spleen adult (RPKM 3.6) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 D1; 13 52.25 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (99321331..99383540)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (99184823..99247032)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Type 1 conventional dendritic cell fate and function are controlled by DC-SCRIPT.
Title: Type 1 conventional dendritic cell fate and function are controlled by DC-SCRIPT.
DC-SCRIPT affects mammary organoids branching morphogenesis by modulating the FGFR1-pERK signaling axis.
Title: DC-SCRIPT affects mammary organoids branching morphogenesis by modulating the FGFR1-pERK signaling axis.
Findings show that zinc finger protein 366 (DC-SCRIPT) deficiency delays mammary gland morphogenesis in vivo and in vitro and indicate DC-SCRIPT as a modulator of mammary gland development.
Title: DC-SCRIPT deficiency delays mouse mammary gland development and branching morphogenesis.
this study shows that PU.1 promotes conventional dendritic cell identity and function via induction of transcriptional regulator DC-SCRIPT
Title: Transcription Factor PU.1 Promotes Conventional Dendritic Cell Identity and Function via Induction of Transcriptional Regulator DC-SCRIPT.
Taken together, these data show that DC-SCRIPT is well-conserved in evolution and that the mouse homologue is more than 80% homologous to the human protein.(DC-SCRIPT protein, mouse)
Title: Molecular characterization of the murine homologue of the DC-derived protein DC-SCRIPT.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (1)
Targeted (1) 1 citation

General gene information

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Markers

D13Mit109 (e-PCR), detects polymorphism
- UniSTS:126933

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear estrogen receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear estrogen receptor binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of intracellular estrogen receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of intracellular estrogen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to estrogen	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to estrogen	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger protein 366

Names: dendritic cell-specific transcript protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004149.1 → NP_001004149.1 zinc finger protein 366

See identical proteins and their annotated locations for NP_001004149.1

Status: PROVISIONAL

Source sequence(s)

BC070399

Consensus CDS

CCDS26720.1

UniProtKB/Swiss-Prot

Q6NS86

Related

ENSMUSP00000060040.9, ENSMUST00000056558.11

Conserved Domains (3) summary

COG5048
Location:250 → 546

COG5048; FOG: Zn-finger [General function prediction only]

PRK10263
Location:51 → 227

PRK10263; DNA translocase FtsK; Provisional

sd00017
Location:252 → 272

ZF_C2H2; C2H2 Zn finger [structural motif]