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    Kif18a kinesin family member 18A [ Mus musculus (house mouse) ]

    Gene ID: 228421, updated on 9-May-2024

    Summary

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    Official Symbol
    Kif18aprovided by MGI
    Official Full Name
    kinesin family member 18Aprovided by MGI
    Primary source
    MGI:MGI:2446977
    See related
    Ensembl:ENSMUSG00000027115 AllianceGenome:MGI:2446977
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    gcd2; B130001M12Rik
    Summary
    Predicted to enable several functions, including ATP hydrolysis activity; cytoskeletal protein binding activity; and plus-end-directed microtubule motor activity. Acts upstream of or within nuclear division; regulation of microtubule cytoskeleton organization; and seminiferous tubule development. Located in kinetochore and mitotic spindle midzone. Is expressed in central nervous system; gonad; and retina. Orthologous to human KIF18A (kinesin family member 18A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver E14 (RPKM 8.8), CNS E11.5 (RPKM 7.2) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kif18a in Genome Data Viewer
    Location:
    2 E3; 2 56.55 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (109111165..109172094)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (109280738..109341749)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05346 Neighboring gene predicted gene 13923 Neighboring gene methyltransferase like 15 Neighboring gene STARR-seq mESC enhancer starr_05347 Neighboring gene STARR-seq mESC enhancer starr_05348 Neighboring gene STARR-seq mESC enhancer starr_05349 Neighboring gene STARR-positive B cell enhancer ABC_E5956 Neighboring gene STARR-seq mESC enhancer starr_05353 Neighboring gene STARR-seq mESC enhancer starr_05354 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene STARR-seq mESC enhancer starr_05355 Neighboring gene brain-derived neurotrophic factor antisense RNA Neighboring gene brain derived neurotrophic factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mitotic chromosome alignment ensures mitotic fidelity by promoting interchromosomal compaction during anaphase. Fonseca CL, et al. J Cell Biol, 2019 Apr 1. PMID 30733233, Free PMC Article
    2. Micronuclei in Kif18a mutant mice form stable micronuclear envelopes and do not promote tumorigenesis. Sepaniac LA, et al. J Cell Biol, 2021 Nov 1. PMID 34515734, Free PMC Article
    3. Kinesin family member KIF18A is a critical cellular factor that regulates the differentiation and activation of dendritic cells. Kim S, et al. Genes Genomics, 2020 Jan. PMID 31677127
    4. Targeted deletion of Kif18a protects from colitis-associated colorectal (CAC) tumors in mice through impairing Akt phosphorylation. Zhu H, et al. Biochem Biophys Res Commun, 2013 Aug 16. PMID 23872115
    5. Germinal Cell Aplasia in Kif18a Mutant Male Mice Due to Impaired Chromosome Congression and Dysregulated BubR1 and CENP-E. Liu XS, et al. Genes Cancer, 2010 Jan. PMID 20981276, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Micronuclei in Kif18a mutant mice form stable micronuclear envelopes and do not promote tumorigenesis.
      Title: Micronuclei in Kif18a mutant mice form stable micronuclear envelopes and do not promote tumorigenesis.
    2. phylogenetic analysis revealed that the KIF18A gene family is remarkably conserved across vertebrates.
      Title: Kinesin family member KIF18A is a critical cellular factor that regulates the differentiation and activation of dendritic cells.
    3. Kif18a is specifically required for mitotic progression during germ line development.
      Title: Kif18a is specifically required for mitotic progression during germ line development.
    4. In conclusion, Kif18a is critical for colorectal carcinogenesis in the setting of inflammation by mechanisms of increased PI3K-AKT signaling.
      Title: Targeted deletion of Kif18a protects from colitis-associated colorectal (CAC) tumors in mice through impairing Akt phosphorylation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC27627

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule plus-end binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables plus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables plus-end-directed microtubule motor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tubulin-dependent ATPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within male meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mitotic metaphase chromosome alignment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic metaphase chromosome alignment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within seminiferous tubule development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in caveola ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitotic spindle astral microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitotic spindle midzone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kinesin-like protein KIF18A
    Names
    N-8 kinesin
    kinesin superfamily protein 18A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418960.1 → NP_001405889.1  kinesin-like protein KIF18A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL691430

    2. NM_001418961.1 → NP_001405890.1  kinesin-like protein KIF18A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL691430
      UniProtKB/TrEMBL
      Q8BZ45
      Related
      ENSMUST00000144924.8

    3. NM_001418962.1 → NP_001405891.1  kinesin-like protein KIF18A isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL691430
      UniProtKB/TrEMBL
      Q8BY99
      Related
      ENSMUST00000151395.8

    4. NM_001418963.1 → NP_001405892.1  kinesin-like protein KIF18A isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL691430

    5. NM_139303.2 → NP_647464.1  kinesin-like protein KIF18A isoform 1

      See identical proteins and their annotated locations for NP_647464.1

      Status: VALIDATED

      Source sequence(s)
      AL691430
      Consensus CDS
      CCDS16507.1
      UniProtKB/Swiss-Prot
      Q3TP77, Q8BLL1, Q91WD7
      Related
      ENSMUSP00000028527.8, ENSMUST00000028527.8
      Conserved Domains (2) summary
      cd01370
      Location:11 → 355
      KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup
      pfam00225
      Location:17 → 355
      Kinesin; Kinesin motor domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      109111165..109172094
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91WD7.1 GenPept UniProtKB/Swiss-Prot:Q91WD7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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