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    Cpz carboxypeptidase Z [ Mus musculus (house mouse) ]

    Gene ID: 242939, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Cpzprovided by MGI
    Official Full Name
    carboxypeptidase Zprovided by MGI
    Primary source
    MGI:MGI:88487
    See related
    Ensembl:ENSMUSG00000036596 AllianceGenome:MGI:88487
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in peptide metabolic process and protein processing. Predicted to act upstream of or within Wnt signaling pathway and proteolysis. Predicted to be located in extracellular matrix. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; ear; genitourinary system; and integumental system. Orthologous to human CPZ (carboxypeptidase Z). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in ovary adult (RPKM 26.2), bladder adult (RPKM 14.2) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 B3; 5 18.16 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (35659562..35682970, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (35502218..35525626, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A930033C23 gene Neighboring gene H6 homeobox 1 Neighboring gene predicted gene, 40283 Neighboring gene STARR-seq mESC enhancer starr_12857 Neighboring gene polo like kinase, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_12858 Neighboring gene tRNA methyltransferase 44 Neighboring gene RIKEN cDNA 4931431C16 gene Neighboring gene STARR-positive B cell enhancer ABC_E3570 Neighboring gene STARR-positive B cell enhancer ABC_E11725 Neighboring gene acyl-Coenzyme A oxidase 3, pristanoyl

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Metallocarboxypeptidase Z is dynamically expressed in mouse development. Novikova E, et al. Mech Dev, 2001 Apr. PMID 11287206
    2. Carboxypeptidase Z (CPZ) modulates Wnt signaling and regulates the development of skeletal elements in the chicken. Moeller C, et al. Development, 2003 Nov. PMID 12944424
    3. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
    4. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallocarboxypeptidase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein processing TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular matrix TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    carboxypeptidase Z

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153107.2 → NP_694747.2  carboxypeptidase Z precursor

      See identical proteins and their annotated locations for NP_694747.2

      Status: VALIDATED

      Source sequence(s)
      AC116705, BX518878, CD742096, CJ067998
      Consensus CDS
      CCDS19229.1
      UniProtKB/Swiss-Prot
      G3X945, Q8R4V4
      Related
      ENSMUSP00000039804.6, ENSMUST00000038676.7
      Conserved Domains (3) summary
      cd03867
      Location:192 → 506
      M14_CPZ; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase Z subgroup
      cd11308
      Location:510 → 586
      Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
      cl02447
      Location:45 → 172
      CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      35659562..35682970 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R4V4.2 GenPept UniProtKB/Swiss-Prot:Q8R4V4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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