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    Dgki diacylglycerol kinase, iota [ Mus musculus (house mouse) ]

    Gene ID: 320127, updated on 12-May-2024

    Summary

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    Official Symbol
    Dgkiprovided by MGI
    Official Full Name
    diacylglycerol kinase, iotaprovided by MGI
    Primary source
    MGI:MGI:2443430
    See related
    Ensembl:ENSMUSG00000038665 AllianceGenome:MGI:2443430
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6430604M11Rik; C130010K08Rik
    Summary
    Enables GTPase inhibitor activity; diacylglycerol kinase activity; and small GTPase binding activity. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within several processes, including chemical synaptic transmission; habituation; and modulation of chemical synaptic transmission. Located in Schaffer collateral - CA1 synapse; glutamatergic synapse; and perinuclear region of cytoplasm. Part of guanyl-nucleotide exchange factor complex. Is expressed in cerebral cortex; cerebral cortex mantle layer; and cerebral cortex marginal layer. Orthologous to human DGKI (diacylglycerol kinase iota). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in frontal lobe adult (RPKM 3.1), cortex adult (RPKM 2.4) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6; 6 B1
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (36814316..37281034, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (36837381..37300955, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15571 Neighboring gene predicted gene 2189 Neighboring gene STARR-seq mESC enhancer starr_15572 Neighboring gene pleiotrophin Neighboring gene predicted gene, 53282 Neighboring gene STARR-seq mESC enhancer starr_15573 Neighboring gene predicted gene, 52857 Neighboring gene STARR-seq mESC enhancer starr_15575 Neighboring gene predicted pseudogene 7452 Neighboring gene STARR-seq mESC enhancer starr_15579 Neighboring gene cAMP responsive element binding protein 3-like 2 Neighboring gene STARR-positive B cell enhancer mm9_chr6:37392120-37392421 Neighboring gene predicted gene, 33275 Neighboring gene predicted gene, 33318

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Enhanced histamine-induced itch in diacylglycerol kinase iota knockout mice. Bartsch VB, et al. PLoS One, 2019. PMID 31167004, Free PMC Article
    2. Mania- and anxiety-like behavior and impaired maternal care in female diacylglycerol kinase eta and iota double knockout mice. Bartsch VB, et al. Genes Brain Behav, 2020 Mar. PMID 30985063, Free PMC Article
    3. Exome Sequencing Identifies Genes and Gene Sets Contributing to Severe Childhood Obesity, Linking PHIP Variants to Repressed POMC Transcription. Marenne G, et al. Cell Metab, 2020 Jun 2. PMID 32492392, Free PMC Article
    4. Diacylglycerol kinase delta regulates protein kinase C and epidermal growth factor receptor signaling. Crotty T, et al. Proc Natl Acad Sci U S A, 2006 Oct 17. PMID 17021016, Free PMC Article
    5. Diacylglycerol kinase iota regulates Ras guanyl-releasing protein 3 and inhibits Rap1 signaling. Regier DS, et al. Proc Natl Acad Sci U S A, 2005 May 24. PMID 15894621, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mania- and anxiety-like behavior and impaired maternal care in female diacylglycerol kinase eta and iota double knockout mice.
      Title: Mania- and anxiety-like behavior and impaired maternal care in female diacylglycerol kinase eta and iota double knockout mice.
    2. These data suggest Dgki regulates sensory neuron and behavioral responses to histamine.
      Title: Enhanced histamine-induced itch in diacylglycerol kinase iota knockout mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent diacylglycerol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent diacylglycerol kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP-dependent diacylglycerol kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of Ras protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in diacylglycerol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in diacylglycerol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within excitatory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within habituation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neurotransmitter secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidic acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidic acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of Ras protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein kinase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of long-term synaptic depression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of synaptic transmission, glutamatergic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Schaffer collateral - CA1 synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in axon terminus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in excitatory synapse ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in extrinsic component of postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extrinsic component of presynaptic active zone membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of guanyl-nucleotide exchange factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in presynaptic active zone ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in synaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    diacylglycerol kinase iota
    Names
    DAG kinase iota
    NP_001074675.1
    NP_001334033.1
    XP_006506321.1
    XP_006506322.1
    XP_011239687.1
    XP_017177113.1
    XP_017177114.1
    XP_017177115.1
    XP_017177116.1
    XP_017177117.1
    XP_017177118.1
    XP_017177119.1
    XP_017177121.1
    XP_017177122.1
    XP_030111313.1
    XP_030111314.1
    XP_036022113.1
    XP_036022114.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081206.2 → NP_001074675.1  diacylglycerol kinase iota isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC154019, AC159480, AK081360
      Consensus CDS
      CCDS39459.1
      UniProtKB/Swiss-Prot
      D3YWQ0, D3Z2W1
      UniProtKB/TrEMBL
      D3Z519
      Related
      ENSMUSP00000099071.4, ENSMUST00000101532.10
      Conserved Domains (7) summary
      smart00045
      Location:521 → 678
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:373 → 494
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG0666
      Location:869 → 1068
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:966 → 997
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:936 → 1031
      Ank_2; Ankyrin repeats (3 copies)
      cd20850
      Location:163 → 235
      C1_DGKiota_rpt1; first protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase iota (DAG kinase iota) and similar proteins
      cd20896
      Location:244 → 318
      C1_DGKiota_rpt2; second protein kinase C conserved region 1 (C1 domain) found in diacylglycerol kinase iota (DAG kinase iota) and similar proteins

    2. NM_001347104.2 → NP_001334033.1  diacylglycerol kinase iota isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC114574, AC154019, AC159480, AC184160
      Consensus CDS
      CCDS85032.1
      UniProtKB/TrEMBL
      D3Z519
      Related
      ENSMUSP00000087788.5, ENSMUST00000090314.11

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      36814316..37281034 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506259.5 → XP_006506322.1  diacylglycerol kinase iota isoform X8

      UniProtKB/TrEMBL
      D3Z519
      Conserved Domains (6) summary
      smart00045
      Location:516 → 673
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:368 → 489
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG0666
      Location:864 → 1063
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:961 → 992
      ANK; ANK repeat [structural motif]
      pfam00130
      Location:246 → 303
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam12796
      Location:931 → 1026
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_011241385.4 → XP_011239687.1  diacylglycerol kinase iota isoform X16

      UniProtKB/TrEMBL
      D3Z519
      Conserved Domains (6) summary
      smart00045
      Location:520 → 677
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:372 → 493
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG0666
      Location:832 → 1031
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:929 → 960
      ANK; ANK repeat [structural motif]
      pfam00130
      Location:246 → 303
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam12796
      Location:899 → 994
      Ank_2; Ankyrin repeats (3 copies)

    3. XM_006506258.5 → XP_006506321.1  diacylglycerol kinase iota isoform X7

      UniProtKB/TrEMBL
      D3Z519
      Conserved Domains (6) summary
      smart00045
      Location:520 → 677
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:372 → 493
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG0666
      Location:868 → 1067
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:965 → 996
      ANK; ANK repeat [structural motif]
      pfam00130
      Location:246 → 303
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam12796
      Location:935 → 1030
      Ank_2; Ankyrin repeats (3 copies)

    4. XM_030255453.2 → XP_030111313.1  diacylglycerol kinase iota isoform X9

      UniProtKB/TrEMBL
      D3Z519
      Conserved Domains (6) summary
      smart00045
      Location:521 → 678
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:373 → 494
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG0666
      Location:854 → 1053
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:951 → 982
      ANK; ANK repeat [structural motif]
      pfam00130
      Location:246 → 303
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam12796
      Location:921 → 1016
      Ank_2; Ankyrin repeats (3 copies)

    5. XM_017321628.3 → XP_017177117.1  diacylglycerol kinase iota isoform X5

      UniProtKB/TrEMBL
      D3Z519
      Conserved Domains (6) summary
      smart00045
      Location:561 → 718
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:413 → 534
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG0666
      Location:888 → 1087
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:985 → 1016
      ANK; ANK repeat [structural motif]
      pfam00130
      Location:246 → 303
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam12796
      Location:955 → 1050
      Ank_2; Ankyrin repeats (3 copies)

    6. XM_017321625.3 → XP_017177114.1  diacylglycerol kinase iota isoform X2

      Conserved Domains (6) summary
      smart00045
      Location:561 → 718
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:413 → 534
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG0666
      Location:909 → 1108
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:1006 → 1037
      ANK; ANK repeat [structural motif]
      pfam00130
      Location:246 → 303
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam12796
      Location:976 → 1071
      Ank_2; Ankyrin repeats (3 copies)

    7. XM_017321629.3 → XP_017177118.1  diacylglycerol kinase iota isoform X6

      UniProtKB/TrEMBL
      D3Z519
      Conserved Domains (6) summary
      smart00045
      Location:562 → 719
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:414 → 535
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG0666
      Location:874 → 1073
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:971 → 1002
      ANK; ANK repeat [structural motif]
      pfam00130
      Location:246 → 303
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam12796
      Location:941 → 1036
      Ank_2; Ankyrin repeats (3 copies)

    8. XM_017321627.3 → XP_017177116.1  diacylglycerol kinase iota isoform X4

      UniProtKB/TrEMBL
      D3Z519
      Conserved Domains (6) summary
      smart00045
      Location:562 → 719
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:414 → 535
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG0666
      Location:889 → 1088
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:986 → 1017
      ANK; ANK repeat [structural motif]
      pfam00130
      Location:246 → 303
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam12796
      Location:956 → 1051
      Ank_2; Ankyrin repeats (3 copies)

    9. XM_017321626.3 → XP_017177115.1  diacylglycerol kinase iota isoform X3

      Conserved Domains (6) summary
      smart00045
      Location:562 → 719
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:414 → 535
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG0666
      Location:895 → 1094
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:992 → 1023
      ANK; ANK repeat [structural motif]
      pfam00130
      Location:246 → 303
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam12796
      Location:962 → 1057
      Ank_2; Ankyrin repeats (3 copies)

    10. XM_017321624.3 → XP_017177113.1  diacylglycerol kinase iota isoform X1

      Conserved Domains (6) summary
      smart00045
      Location:562 → 719
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:414 → 535
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG0666
      Location:910 → 1109
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:1007 → 1038
      ANK; ANK repeat [structural motif]
      pfam00130
      Location:246 → 303
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam12796
      Location:977 → 1072
      Ank_2; Ankyrin repeats (3 copies)

    11. XM_036166220.1 → XP_036022113.1  diacylglycerol kinase iota isoform X13

      UniProtKB/TrEMBL
      D3Z519
      Conserved Domains (6) summary
      smart00045
      Location:226 → 383
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:78 → 199
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG0666
      Location:574 → 773
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:671 → 702
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:641 → 736
      Ank_2; Ankyrin repeats (3 copies)
      cl00040
      Location:1 → 23
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    12. XM_036166221.1 → XP_036022114.1  diacylglycerol kinase iota isoform X14

      UniProtKB/TrEMBL
      D3Z519
      Conserved Domains (5) summary
      smart00045
      Location:196 → 353
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:48 → 169
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG0666
      Location:544 → 743
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:641 → 672
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:611 → 706
      Ank_2; Ankyrin repeats (3 copies)

    13. XM_030255454.2 → XP_030111314.1  diacylglycerol kinase iota isoform X12

      UniProtKB/TrEMBL
      S4R2G0
      Conserved Domains (3) summary
      smart00045
      Location:516 → 673
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:368 → 489
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      pfam00130
      Location:246 → 303
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    14. XM_017321632.3 → XP_017177121.1  diacylglycerol kinase iota isoform X11

      UniProtKB/TrEMBL
      S4R2G0
      Conserved Domains (3) summary
      smart00045
      Location:562 → 719
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:414 → 535
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      pfam00130
      Location:246 → 303
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    15. XM_017321630.3 → XP_017177119.1  diacylglycerol kinase iota isoform X10

      UniProtKB/TrEMBL
      S4R2G0
      Related
      ENSMUSP00000138628.2, ENSMUST00000138286.8
      Conserved Domains (3) summary
      smart00045
      Location:562 → 719
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:414 → 535
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      pfam00130
      Location:246 → 303
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    16. XM_017321633.3 → XP_017177122.1  diacylglycerol kinase iota isoform X15

      UniProtKB/TrEMBL
      S4R215
      Related
      ENSMUSP00000138457.2, ENSMUST00000150300.9
      Conserved Domains (3) summary
      smart00046
      Location:414 → 535
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      pfam00130
      Location:246 → 303
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl02440
      Location:562 → 624
      DAGK_acc; Diacylglycerol kinase accessory domain

    RNA

    1. XR_004942967.1 RNA Sequence

    2. XR_004942966.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3YWQ0.1 GenPept UniProtKB/Swiss-Prot:D3YWQ0

    Gene LinkOut

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