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    Tmem141 transmembrane protein 141 [ Mus musculus (house mouse) ]

    Gene ID: 51875, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tmem141provided by MGI
    Official Full Name
    transmembrane protein 141provided by MGI
    Primary source
    MGI:MGI:1098773
    See related
    Ensembl:ENSMUSG00000026939 AllianceGenome:MGI:1098773
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D2Ertd217e; 1110065P14Rik
    Summary
    Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in retina. Orthologous to human TMEM141 (transmembrane protein 141). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 17.0), bladder adult (RPKM 12.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem141 in Genome Data Viewer
    Location:
    2 A3; 2 17.57 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25510078..25512059, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25620066..25622047, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RAB, member RAS oncogene family-like 6 Neighboring gene coiled-coil domain containing 183 Neighboring gene ficolin A, opposite strand Neighboring gene ficolin A Neighboring gene predicted gene, 35630 Neighboring gene lipocalin 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Barhl1, a gene belonging to a new subfamily of mammalian homeobox genes, is expressed in migrating neurons of the CNS. Bulfone A, et al. Hum Mol Genet, 2000 May 22. PMID 10814725
    2. Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Lumayag S, et al. Proc Natl Acad Sci U S A, 2013 Feb 5. PMID 23341629, Free PMC Article
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 141

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040130.3 → NP_001035219.2  transmembrane protein 141 isoform 1

      See identical proteins and their annotated locations for NP_001035219.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AI852650, AK004380, BY648636, BY704611, CD774285
      Consensus CDS
      CCDS50534.1
      UniProtKB/Swiss-Prot
      A2AJB2
      UniProtKB/TrEMBL
      F8WGV9
      Related
      ENSMUSP00000121862.2, ENSMUST00000142087.2
      Conserved Domains (1) summary
      pfam15110
      Location:6 → 96
      TMEM141; TMEM141 protein family

    2. NM_001109993.1 → NP_001103463.1  transmembrane protein 141 isoform 2

      See identical proteins and their annotated locations for NP_001103463.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus when compared to isoform 1.
      Source sequence(s)
      AI852650, BC048537, BY281807, CD774285
      UniProtKB/TrEMBL
      Q80ZR4
      Related
      ENSMUST00000150165.8
      Conserved Domains (1) summary
      pfam15110
      Location:1 → 65
      TMEM141; TMEM141 protein family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      25510078..25512059 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498180.4 → XP_006498243.1  transmembrane protein 141 isoform X1

      See identical proteins and their annotated locations for XP_006498243.1

      UniProtKB/TrEMBL
      Q80ZR4
      Conserved Domains (1) summary
      pfam15110
      Location:1 → 65
      TMEM141; TMEM141 protein family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AJB2.1 GenPept UniProtKB/Swiss-Prot:A2AJB2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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