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    Meak7 MTOR associated protein, eak-7 homolog [ Mus musculus (house mouse) ]

    Gene ID: 74347, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Meak7provided by MGI
    Official Full Name
    MTOR associated protein, eak-7 homologprovided by MGI
    Primary source
    MGI:MGI:1921597
    See related
    Ensembl:ENSMUSG00000034105 AllianceGenome:MGI:1921597
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tldc1; Kiaa1609; 4632415K11Rik
    Summary
    Acts upstream of or within negative regulation of oxidative stress-induced neuron death. Predicted to be located in cytosol; lysosomal membrane; and nuclear lumen. Is expressed in several structures, including central nervous system; genitourinary system; liver; lung; and spleen. Orthologous to human MEAK7 (MTOR associated protein, eak-7 homolog). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 8.2), colon adult (RPKM 7.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Meak7 in Genome Data Viewer
    Location:
    8 E1; 8 68.32 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (120486802..120505173, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (119760063..119778439, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene WAP four-disulfide core domain 1 Neighboring gene predicted gene, 53463 Neighboring gene ATPase, Ca++ transporting, type 2C, member 2 Neighboring gene STARR-positive B cell enhancer mm9_chr8:122241776-122242076 Neighboring gene STARR-positive B cell enhancer ABC_E113 Neighboring gene coactosin like F-actin binding protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:122361795-122361952 Neighboring gene STARR-positive B cell enhancer ABC_E2880 Neighboring gene STARR-positive B cell enhancer mm9_chr8:122367394-122367695 Neighboring gene STARR-positive B cell enhancer ABC_E2881 Neighboring gene kelch-like 36

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Evolutionarily Conserved Tre2/Bub2/Cdc16 (TBC), Lysin Motif (LysM), Domain Catalytic (TLDc) Domain Is Neuroprotective against Oxidative Stress. Finelli MJ, et al. J Biol Chem, 2016 Feb 5. PMID 26668325, Free PMC Article
    2. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of cellular response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to amino acid ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to insulin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to nutrient levels ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    MTOR-associated protein MEAK7
    Names
    MTOR associated protein , eak-7 homolog
    TBC/LysM associated domain containing 1
    TBC/LysM-associated domain-containing protein 1
    TLD domain-containing protein 1
    NP_083159.1
    XP_030099677.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028883.2 → NP_083159.1  MTOR-associated protein MEAK7

      See identical proteins and their annotated locations for NP_083159.1

      Status: PROVISIONAL

      Source sequence(s)
      AC161435
      Consensus CDS
      CCDS40494.1
      UniProtKB/Swiss-Prot
      Q69ZF1, Q8K0P3
      Related
      ENSMUSP00000044430.6, ENSMUST00000049156.7
      Conserved Domains (1) summary
      smart00584
      Location:242 → 410
      TLDc; domain in TBC and LysM domain containing proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      120486802..120505173 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243817.2 → XP_030099677.1  MTOR-associated protein MEAK7 isoform X1

      UniProtKB/Swiss-Prot
      Q69ZF1, Q8K0P3
      Conserved Domains (1) summary
      smart00584
      Location:242 → 410
      TLDc; domain in TBC and LysM domain containing proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K0P3.1 GenPept UniProtKB/Swiss-Prot:Q8K0P3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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