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    Wdr5b WD repeat domain 5B [ Mus musculus (house mouse) ]

    Gene ID: 69544, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Wdr5bprovided by MGI
    Official Full Name
    WD repeat domain 5Bprovided by MGI
    Primary source
    MGI:MGI:1916794
    See related
    Ensembl:ENSMUSG00000034379 AllianceGenome:MGI:1916794
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310009C03Rik
    Summary
    Predicted to enable histone binding activity. Predicted to be involved in histone H3-K4 methylation. Predicted to be part of Set1C/COMPASS complex. Orthologous to human WDR5B (WD repeat domain 5B). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human all
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    Genomic context

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    See Wdr5b in Genome Data Viewer
    Location:
    16 B3; 16 25.43 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (35861560..35863344)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (36041190..36042974)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene poly (ADP-ribose) polymerase family, member 9 Neighboring gene STARR-seq mESC enhancer starr_40752 Neighboring gene predicted gene 15564 Neighboring gene karyopherin subunit alpha 1 Neighboring gene STARR-positive B cell enhancer ABC_E5540 Neighboring gene family with sequence similarity 162, member A Neighboring gene STARR-seq mESC enhancer starr_40755 Neighboring gene mitochondrial matrix import factor 23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. Higa LA, et al. Nat Cell Biol, 2006 Nov. PMID 17041588
    2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Set1C/COMPASS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat-containing protein 5B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027113.2 → NP_081389.1  WD repeat-containing protein 5B

      See identical proteins and their annotated locations for NP_081389.1

      Status: PROVISIONAL

      Source sequence(s)
      BC064045
      Consensus CDS
      CCDS28145.1
      UniProtKB/Swiss-Prot
      Q9D7H2
      Related
      ENSMUSP00000040852.9, ENSMUST00000042203.10
      Conserved Domains (3) summary
      COG2319
      Location:34 → 325
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:31 → 325
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:42 → 79
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      35861560..35863344
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D7H2.1 GenPept UniProtKB/Swiss-Prot:Q9D7H2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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