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    TMEM201 transmembrane protein 201 [ Homo sapiens (human) ]

    Gene ID: 199953, updated on 3-Apr-2024

    Summary

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    Official Symbol
    TMEM201provided by HGNC
    Official Full Name
    transmembrane protein 201provided by HGNC
    Primary source
    HGNC:HGNC:33719
    See related
    Ensembl:ENSG00000188807 AllianceGenome:HGNC:33719
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Ima1; NET5; SAMP1
    Summary
    Predicted to enable actin filament binding activity and lamin binding activity. Involved in centrosome localization; nuclear envelope organization; and protein localization to nuclear envelope. Located in nuclear envelope. Is integral component of nuclear inner membrane. Colocalizes with cortical endoplasmic reticulum and spindle pole centrosome. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 3.5), endometrium (RPKM 2.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TMEM201 in Genome Data Viewer
    Location:
    1p36.22
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (9588911..9614877)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (9125255..9151173)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (9648969..9674935)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 40 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9533371-9533922 Neighboring gene MPRA-validated peak54 silencer Neighboring gene Sharpr-MPRA regulatory region 9854 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 222 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 129 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9601405-9601904 Neighboring gene solute carrier family 25 member 33 Neighboring gene MPRA-validated peak56 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 223 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 224 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 225 Neighboring gene hESC enhancers GRCh37_chr1:9653469-9654066 and GRCh37_chr1:9654067-9654663 Neighboring gene ribosomal protein L9 pseudogene 11 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:9657808-9659007 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:9671778-9672013 Neighboring gene uncharacterized LOC124903837 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9675483-9676027 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 130 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 131 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 226 Neighboring gene nonconserved acetylation island sequence 67 enhancer Neighboring gene uncharacterized LOC105376712 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 227 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 132 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 133 Neighboring gene phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 134 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 135 Neighboring gene PIK3CD antisense RNA 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Characterization of the Clinical Significance and Immunological Landscapes of a Novel TMEMs Signature in Hepatocellular Carcinoma and the Contribution of TMEM201 to Hepatocarcinogenesis. Chen D, et al. Int J Mol Sci, 2023 Jun 17. PMID 37373430, Free PMC Article
    2. Monitoring of chromatin organization in live cells by FRIC. Effects of the inner nuclear membrane protein Samp1. Bergqvist C, et al. Nucleic Acids Res, 2019 May 21. PMID 30793190, Free PMC Article
    3. Mitotic spindle assembly and γ-tubulin localisation depend on the integral nuclear membrane protein Samp1. Larsson VJ, et al. J Cell Sci, 2018 Apr 13. PMID 29514856, Free PMC Article
    4. An inner nuclear membrane protein induces rapid differentiation of human induced pluripotent stem cells. Bergqvist C, et al. Stem Cell Res, 2017 Aug. PMID 28668644
    5. A transmembrane inner nuclear membrane protein in the mitotic spindle. Figueroa R, et al. Nucleus, 2010 May-Jun. PMID 21327071, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Characterization of the Clinical Significance and Immunological Landscapes of a Novel TMEMs Signature in Hepatocellular Carcinoma and the Contribution of TMEM201 to Hepatocarcinogenesis.
      Title: Characterization of the Clinical Significance and Immunological Landscapes of a Novel TMEMs Signature in Hepatocellular Carcinoma and the Contribution of TMEM201 to Hepatocarcinogenesis.
    2. Inner nuclear membrane protein TMEM201 maintains endothelial cell migration and angiogenesis by interacting with the LINC complex.
      Title: Inner nuclear membrane protein TMEM201 maintains endothelial cell migration and angiogenesis by interacting with the LINC complex.
    3. Authors show that Samp1 is involved in the recruitment of HAUS6 and gamma-tubulin to the mitotic spindle. Samp1 is the first inner nuclear membrane protein shown to have a function in mitotic spindle assembly.
      Title: Mitotic spindle assembly and γ-tubulin localisation depend on the integral nuclear membrane protein Samp1.
    4. We also found that peripheral heterochromatin depended on the levels of the inner nuclear membrane protein Samp1, suggesting an important role in promoting peripheral heterochromatin. Taken together, FRIC is a powerful and robust new tool to study dynamic chromatin redistribution in live cells.
      Title: Monitoring of chromatin organization in live cells by FRIC. Effects of the inner nuclear membrane protein Samp1.
    5. the mobility of YFP-Emerin was higher in Samp1 knock out cells and lower in cells overexpressing Samp1, suggesting that Samp1 significantly attenuates the mobility of Emerin in the nuclear envelope. The affinity between Samp1 and Emerin is decreased in the presence of Ran, suggesting that Ran attenuates the interaction between Samp1 and Emerin.
      Title: RanGTPase regulates the interaction between the inner nuclear membrane proteins, Samp1 and Emerin.
    6. Samp1 is involved in early differentiation of induced pluripotent stem cells.
      Title: An inner nuclear membrane protein induces rapid differentiation of human induced pluripotent stem cells.
    7. the nucleoplasmic domains of Samp1 and Emerin can bind directly to each other.
      Title: MCLIP, an effective method to detect interactions of transmembrane proteins of the nuclear envelope in live cells.
    8. characterization of a transmembrane protein of the nuclear envelope that we name spindle-associated membrane protein 1 (Samp1); Samp1 defines a specific membrane domain associated with the mitotic spindle
      Title: An integral protein of the inner nuclear membrane localizes to the mitotic spindle in mammalian cells.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lamin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in fibroblast migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear migration along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nuclear membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 201
    Names
    RP13-15M17.2
    spindle-associated membrane protein 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001010866.4 → NP_001010866.1  transmembrane protein 201 isoform 2

      See identical proteins and their annotated locations for NP_001010866.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a distinct 3' coding region and 3' UTR and lacks multiple 3' exons, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC121187, BC137291
      Consensus CDS
      CCDS30579.1
      UniProtKB/Swiss-Prot
      Q5SNT2
      Related
      ENSP00000344772.5, ENST00000340305.9
      Conserved Domains (2) summary
      pfam09779
      Location:47 → 169
      Ima1_N; Ima1 N-terminal domain
      pfam10476
      Location:192 → 387
      DUF2448; Protein of unknown function C-terminus (DUF2448)

    2. NM_001130924.3 → NP_001124396.2  transmembrane protein 201 isoform 1

      See identical proteins and their annotated locations for NP_001124396.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC137291, BE676679, BG828926, BX648377
      Consensus CDS
      CCDS44055.2
      UniProtKB/Swiss-Prot
      B9EH90, Q5SNT2, Q5SNT3
      UniProtKB/TrEMBL
      H0Y4R5
      Related
      ENSP00000344503.6, ENST00000340381.11
      Conserved Domains (2) summary
      pfam09779
      Location:47 → 169
      Ima1_N; Ima1 N-terminal domain
      pfam10476
      Location:192 → 379
      DUF2448; Protein of unknown function C-terminus (DUF2448)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      9588911..9614877
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017000549.2 → XP_016856038.1  transmembrane protein 201 isoform X1

    2. XM_017000550.2 → XP_016856039.1  transmembrane protein 201 isoform X2

    3. XM_006710417.4 → XP_006710480.1  transmembrane protein 201 isoform X4

      UniProtKB/TrEMBL
      H0Y4R5
      Related
      ENSP00000393626.1, ENST00000416541.5
      Conserved Domains (2) summary
      pfam09779
      Location:47 → 169
      Ima1_N; Ima1 N-terminal domain
      pfam10476
      Location:192 → 379
      DUF2448; Protein of unknown function C-terminus (DUF2448)

    4. XM_047448441.1 → XP_047304397.1  transmembrane protein 201 isoform X5

    5. XM_011540910.3 → XP_011539212.1  transmembrane protein 201 isoform X6

      See identical proteins and their annotated locations for XP_011539212.1

      UniProtKB/Swiss-Prot
      Q5SNT2
      Conserved Domains (2) summary
      pfam09779
      Location:47 → 169
      Ima1_N; Ima1 N-terminal domain
      pfam10476
      Location:192 → 387
      DUF2448; Protein of unknown function C-terminus (DUF2448)

    6. XM_017000552.3 → XP_016856041.1  transmembrane protein 201 isoform X3

    7. XM_017000551.3 → XP_016856040.1  transmembrane protein 201 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      9125255..9151173
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334893.1 → XP_054190868.1  transmembrane protein 201 isoform X1

    2. XM_054334894.1 → XP_054190869.1  transmembrane protein 201 isoform X2

    3. XM_054334897.1 → XP_054190872.1  transmembrane protein 201 isoform X4

    4. XM_054334898.1 → XP_054190873.1  transmembrane protein 201 isoform X5

    5. XM_054334899.1 → XP_054190874.1  transmembrane protein 201 isoform X6

    6. XM_054334896.1 → XP_054190871.1  transmembrane protein 201 isoform X3

    7. XM_054334895.1 → XP_054190870.1  transmembrane protein 201 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SNT2.1 GenPept UniProtKB/Swiss-Prot:Q5SNT2

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