Eef1g eukaryotic translation elongation factor 1 gamma [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eef1gprovided by MGI
Official Full Name: eukaryotic translation elongation factor 1 gammaprovided by MGI
Primary source: MGI:MGI:1914410
See related: Ensembl:ENSMUSG00000071644 AllianceGenome:MGI:1914410
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EF1G; 2610301D06Rik
Summary: Predicted to enable translation elongation factor activity. Predicted to be involved in translational elongation. Predicted to act upstream of or within translation. Predicted to be active in cytoplasm and nucleus. Predicted to colocalize with endoplasmic reticulum. Is expressed in 2nd branchial arch; 3rd branchial pouch; and early conceptus. Orthologous to human EEF1G (eukaryotic translation elongation factor 1 gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 183.6), testis adult (RPKM 170.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 6.04 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (8944405..8955544)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (8967041..8978180)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:493314 (e-PCR)
- UniSTS:493314

NoName (e-PCR)
- UniSTS:237888

NoName (e-PCR)
- UniSTS:237890

UniSTS:498300 (e-PCR)
- UniSTS:498300

Eef1g (e-PCR), detects polymorphism
- UniSTS:498300

RH125672 (e-PCR)
- UniSTS:162453

MARC_5385-5386:991939571:3 (e-PCR)
- UniSTS:231150

Eef1g (e-PCR), detects polymorphism
- UniSTS:526073

Tut1 (e-PCR), detects polymorphism
- UniSTS:479228

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables translation elongation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info
involved_in translational elongation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
colocalizes_with endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: elongation factor 1-gamma

Names: EF-1-gamma; eEF-1B gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026007.4 → NP_080283.3 elongation factor 1-gamma

See identical proteins and their annotated locations for NP_080283.3

Status: VALIDATED

Source sequence(s)

AK145519

Consensus CDS

CCDS29563.1

UniProtKB/Swiss-Prot

Q920C5, Q9CRT5, Q9CSU3, Q9D004, Q9D8N0

UniProtKB/TrEMBL

Q4FZK2

Related

ENSMUSP00000093955.5, ENSMUST00000052248.8

Conserved Domains (5) summary

cd03181
Location:91 → 213

GST_C_EF1Bgamma_like; Glutathione S-transferase C-terminal-like, alpha helical domain of the Gamma subunit of Elongation Factor 1B and similar proteins

COG0625
Location:5 → 202

GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]

cd03044
Location:4 → 82

GST_N_EF1Bgamma; GST_N family, Gamma subunit of Elongation Factor 1B (EFB1gamma) subfamily; EF1Bgamma is part of the eukaryotic translation elongation factor-1 (EF1) complex which plays a central role in the elongation cycle during protein biosynthesis. EF1 consists of ...

pfam00647
Location:275 → 381

EF1G; Elongation factor 1 gamma, conserved domain

cl15270
Location:211 → 265

FinO_conjug_rep; FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which ...