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    Cltb clathrin light chain B [ Mus musculus (house mouse) ]

    Gene ID: 74325, updated on 12-May-2024

    Summary

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    Official Symbol
    Cltbprovided by MGI
    Official Full Name
    clathrin light chain Bprovided by MGI
    Primary source
    MGI:MGI:1921575
    See related
    Ensembl:ENSMUSG00000047547 AllianceGenome:MGI:1921575
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    lcb; 2310046E19Rik
    Summary
    Predicted to enable clathrin heavy chain binding activity and peptide binding activity. Predicted to be involved in clathrin coat assembly and clathrin-dependent endocytosis. Located in ciliary membrane and trans-Golgi network. Is expressed in central nervous system; dorsal root ganglion; liver; and neural retina. Orthologous to human CLTB (clathrin light chain B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 62.4), frontal lobe adult (RPKM 47.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cltb in Genome Data Viewer
    Location:
    13 B1; 13 28.84 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (54740199..54759186, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (54592386..54611373, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E927 Neighboring gene NOP16 nucleolar protein Neighboring gene HIG1 domain family, member 2A Neighboring gene STARR-seq mESC enhancer starr_34588 Neighboring gene STARR-seq mESC enhancer starr_34589 Neighboring gene STARR-seq mESC enhancer starr_34590 Neighboring gene STARR-seq mESC enhancer starr_34591 Neighboring gene Fas associated factor family member 2 Neighboring gene 4.5s RNA, pseudogene 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:54788483-54788694 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:54789238-54789421 Neighboring gene STARR-positive B cell enhancer ABC_E2408 Neighboring gene ring finger protein 44 Neighboring gene STARR-positive B cell enhancer ABC_E3083

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Clathrin light chain diversity regulates membrane deformation in vitro and synaptic vesicle formation in vivo. Redlingshöfer L, et al. Proc Natl Acad Sci U S A, 2020 Sep 22. PMID 32907943, Free PMC Article
    2. The ciliary pocket: an endocytic membrane domain at the base of primary and motile cilia. Molla-Herman A, et al. J Cell Sci, 2010 May 15. PMID 20427320
    3. Expression of mRNA and protein-protein interaction of the antiviral endoribonuclease RNase L in mouse spleen. Gupta A, et al. Int J Biol Macromol, 2014 Aug. PMID 24780566
    4. Clathrin light chain A drives selective myosin VI recruitment to clathrin-coated pits under membrane tension. Biancospino M, et al. Nat Commun, 2019 Oct 31. PMID 31672988, Free PMC Article
    5. Assembly of the cochlear gap junction macromolecular complex requires connexin 26. Kamiya K, et al. J Clin Invest, 2014 Apr. PMID 24590285, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clathrin light chains CLCa and CLCb have non-redundant roles in epithelial lumen formation.
      Title: Clathrin light chains CLCa and CLCb have non-redundant roles in epithelial lumen formation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables clathrin heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in ciliary membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of clathrin coat ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of clathrin coat of coated pit IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of clathrin coat of trans-Golgi network vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of clathrin vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic endocytic zone cytoplasmic component IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in presynaptic endocytic zone membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    clathrin light chain B
    Names
    clathrin, light polypeptide (Lcb)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347512.1 → NP_001334441.1  clathrin light chain B isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK167531, BC070404, BE991851, BQ173953, BY075785, BY256386
      Consensus CDS
      CCDS84024.1
      UniProtKB/Swiss-Prot
      Q6IRU5, Q8BR04, Q8CDX9, Q9CV35
      UniProtKB/TrEMBL
      Q3TJ95
      Related
      ENSMUSP00000053371.8, ENSMUST00000049575.8

    2. NM_028870.4 → NP_083146.1  clathrin light chain B isoform b

      See identical proteins and their annotated locations for NP_083146.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      AK159480, BE991851, BQ173953, BY075785, BY256386
      Consensus CDS
      CCDS26533.1
      UniProtKB/TrEMBL
      Q3TJ95, Q3TWZ9
      Related
      ENSMUSP00000089198.5, ENSMUST00000091609.11
      Conserved Domains (1) summary
      pfam01086
      Location:1 → 208
      Clathrin_lg_ch; Clathrin light chain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      54740199..54759186 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IRU5.1 GenPept UniProtKB/Swiss-Prot:Q6IRU5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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