Ppp1r9a protein phosphatase 1, regulatory subunit 9A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppp1r9aprovided by MGI
Official Full Name: protein phosphatase 1, regulatory subunit 9Aprovided by MGI
Primary source: MGI:MGI:2442401
See related: Ensembl:ENSMUSG00000032827 AllianceGenome:MGI:2442401
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NRB; 5330407E15; neurabin-I; 2810430P21Rik; 4930518N04Rik; A230094E16Rik
Summary: Predicted to enable several functions, including enzyme binding activity; protein C-terminus binding activity; and transmembrane transporter binding activity. Involved in modulation of chemical synaptic transmission. Acts upstream of or within actin filament organization and calcium-mediated signaling. Located in cortical actin cytoskeleton; dendritic spine; and filopodium. Is expressed in several structures, including brain; extraembryonic component; genitourinary system; hemolymphoid system gland; and skeletal muscle. Orthologous to human PPP1R9A (protein phosphatase 1 regulatory subunit 9A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in cortex adult (RPKM 12.5), frontal lobe adult (RPKM 11.0) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 A1; 6 1.86 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (4902702..5165661)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (4902872..5165661)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

two homologs neurabin and spinophilin play important yet distinct roles in the regulation of anxiety- and depression-like behaviors in an age-dependent manner.
Title: Age-dependent differential regulation of anxiety- and depression-related behaviors by neurabin and spinophilin.
Data indicate that In arrestin 3 deficient mice, where the alpha2B adrenergic receptor has a stronger binding to spinophilin, the hypertensive response is enhanced.
Title: Spinophilin Is Indispensable for the α2B Adrenergic Receptor-Elicited Hypertensive Response.
Data show that the anterior cingulate cortex modulates anxiety-like behavior in adult mice, and show that neurabin is critical for this modulation.
Title: Neurabin in the anterior cingulate cortex regulates anxiety-like behavior in adult mice.
Ppp1r9a gene, found in a cluster of imprinted genes on chromosome 6, is preferentially expressed from the maternal allele at embryonic stages, but biallelically expressed in neonatal tissues.
Title: Identification of a large novel imprinted gene cluster on mouse proximal chromosome 6.
The spinophilin interactome was charaterized in subcellular fractions solubilized from adult rodent striatum.
Title: Identification and validation of novel spinophilin-associated proteins in rodent striatum using an enhanced ex vivo shotgun proteomics approach.
results indicate that neurabin regulates contextual fear memory and LTP in hippocampal CA1 pyramidal neurons
Title: Neurabin contributes to hippocampal long-term potentiation and contextual fear memory.
Neurabin I mediates Rac3-induced neuritogenesis, possibly by anchoring Rac3 to growth cone F-actin.
Title: Rac3-induced neuritogenesis requires binding to Neurabin I.
there is a novel PP1gamma1-selective interaction domain in neurabin that may allow for selective regulation and/or subcellular targeting of PP1 isoforms
Title: A protein phosphatase-1gamma1 isoform selectivity determinant in dendritic spine-associated neurabin.
These data establish a requirement for synaptic scaffolding in dopamine-mediated responses, and further indicate that spinophilin and neurabin play distinct roles in dopaminergic signal transduction and psychostimulant response.
Title: Distinct roles for spinophilin and neurabin in dopamine-mediated plasticity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BB181831 (e-PCR)
- UniSTS:185652

Ppp1r9a (e-PCR), detects polymorphism
- UniSTS:273730

NoName (e-PCR)
- UniSTS:235381

NoName (e-PCR)
- UniSTS:532171

Ppp1r9a (e-PCR), detects polymorphism
- UniSTS:532171

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase 1 binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within actin filament organization	IPI Inferred from Physical Interaction more info	PubMed
involved_in calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within calcium-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to toxic substance	ISO Inferred from Sequence Orthology more info
involved_in excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of spontaneous neurotransmitter secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron projection development	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of dendritic spine development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of long-term synaptic depression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of synapse structural plasticity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cortical actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in dendritic spine neck	ISO Inferred from Sequence Orthology more info
located_in filopodium	IDA Inferred from Direct Assay more info	PubMed
located_in filopodium	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISO Inferred from Sequence Orthology more info	PubMed
located_in growth cone lamellipodium	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic actin cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: neurabin-1

Names: neural tissue-specific F-actin binding protein; protein phosphatase 1, regulatory (inhibitor) subunit 9A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001363809.1 → NP_001350738.1 neurabin-1 isoform 1

Status: VALIDATED

Source sequence(s)

AC068500, AC074225

Consensus CDS

CCDS19897.1

UniProtKB/TrEMBL

H3BL28, Q7TN74

Related

ENSMUSP00000135629.2, ENSMUST00000175889.8

Conserved Domains (4) summary

cd09512
Location:983 → 1052

SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily

smart00228
Location:502 → 593

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

TIGR02168
Location:659 → 927

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam17817
Location:435 → 498

PDZ_5; PDZ domain
NM_001401494.1 → NP_001388423.1 neurabin-1 isoform 3

Status: VALIDATED

Source sequence(s)

AC068500, AC074225
NM_001401496.1 → NP_001388425.1 neurabin-1 isoform 2

Status: VALIDATED

Source sequence(s)

AC068500, AC074225
NM_181595.4 → NP_853626.1 neurabin-1 isoform 1

See identical proteins and their annotated locations for NP_853626.1

Status: VALIDATED

Source sequence(s)

AC068500, AC074225

Consensus CDS

CCDS19897.1

UniProtKB/TrEMBL

H3BL28, Q7TN74

Related

ENSMUSP00000046906.3, ENSMUST00000035813.9

Conserved Domains (4) summary

cd09512
Location:983 → 1052

SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily

smart00228
Location:502 → 593

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

TIGR02168
Location:659 → 927

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam17817
Location:435 → 498

PDZ_5; PDZ domain

RNA

NR_156747.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC068500, AC074225

Related

ENSMUST00000164110.9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

4902702..5165661

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036166122.1 → XP_036022015.1 neurabin-1 isoform X3

UniProtKB/TrEMBL

H3BL28

Conserved Domains (4) summary

cd09512
Location:1188 → 1257

SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily

smart00228
Location:502 → 593

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

TIGR02168
Location:659 → 904

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam17817
Location:435 → 498

PDZ_5; PDZ domain
XM_036166126.1 → XP_036022019.1 neurabin-1 isoform X9

UniProtKB/TrEMBL

H3BL28

Conserved Domains (4) summary

cd09512
Location:931 → 1000

SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily

smart00228
Location:502 → 593

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

TIGR02168
Location:606 → 875

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam17817
Location:435 → 498

PDZ_5; PDZ domain
XM_006505070.3 → XP_006505133.1 neurabin-1 isoform X1

See identical proteins and their annotated locations for XP_006505133.1

Conserved Domains (4) summary

cd09512
Location:1210 → 1279

SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily

smart00228
Location:502 → 593

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

TIGR02168
Location:681 → 926

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam17817
Location:435 → 498

PDZ_5; PDZ domain
XM_006505073.4 → XP_006505136.1 neurabin-1 isoform X2

See identical proteins and their annotated locations for XP_006505136.1

Conserved Domains (4) summary

cd09512
Location:1202 → 1271

SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily

smart00228
Location:502 → 593

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

TIGR02168
Location:681 → 926

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam17817
Location:435 → 498

PDZ_5; PDZ domain
XM_006505078.4 → XP_006505141.1 neurabin-1 isoform X6

UniProtKB/TrEMBL

H3BL28

Related

ENSMUSP00000134937.2, ENSMUST00000176263.8

Conserved Domains (4) summary

cd09512
Location:1005 → 1074

SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily

smart00228
Location:502 → 593

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

TIGR02168
Location:681 → 949

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam17817
Location:435 → 498

PDZ_5; PDZ domain
XM_006505075.3 → XP_006505138.1 neurabin-1 isoform X3

UniProtKB/TrEMBL

H3BL28

Conserved Domains (4) summary

cd09512
Location:1188 → 1257

SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily

smart00228
Location:502 → 593

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

TIGR02168
Location:659 → 904

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam17817
Location:435 → 498

PDZ_5; PDZ domain
XM_006505076.3 → XP_006505139.1 neurabin-1 isoform X4

UniProtKB/TrEMBL

H3BJD6, H3BL28

Related

ENSMUSP00000134943.2, ENSMUST00000177456.8

Conserved Domains (4) summary

cd09512
Location:1180 → 1249

SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily

smart00228
Location:502 → 593

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

TIGR02168
Location:659 → 904

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam17817
Location:435 → 498

PDZ_5; PDZ domain
XM_006505080.3 → XP_006505143.1 neurabin-1 isoform X8

UniProtKB/TrEMBL

H3BL28

Conserved Domains (4) summary

cd09512
Location:975 → 1044

SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily

smart00228
Location:502 → 593

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

TIGR02168
Location:659 → 927

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam17817
Location:435 → 498

PDZ_5; PDZ domain
XM_036166124.1 → XP_036022017.1 neurabin-1 isoform X5

Conserved Domains (4) summary

cd09512
Location:1136 → 1205

SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily

smart00228
Location:502 → 593

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

TIGR02168
Location:606 → 852

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam17817
Location:435 → 498

PDZ_5; PDZ domain
XM_006505082.4 → XP_006505145.1 neurabin-1 isoform X10

UniProtKB/TrEMBL

H3BJD0

Conserved Domains (3) summary

smart00228
Location:502 → 593

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

TIGR02168
Location:681 → 843

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam17817
Location:435 → 498

PDZ_5; PDZ domain
XM_017321591.3 → XP_017177080.1 neurabin-1 isoform X11

UniProtKB/TrEMBL

H3BKQ7

Related

ENSMUSP00000135485.2, ENSMUST00000177153.8

Conserved Domains (3) summary

cd00992
Location:506 → 589

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

TIGR02168
Location:659 → 821

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam17817
Location:435 → 498

PDZ_5; PDZ domain
XM_006505072.4 → XP_006505135.1 neurabin-1 isoform X1

See identical proteins and their annotated locations for XP_006505135.1

Conserved Domains (4) summary

cd09512
Location:1210 → 1279

SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily

smart00228
Location:502 → 593

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

TIGR02168
Location:681 → 926

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam17817
Location:435 → 498

PDZ_5; PDZ domain
XM_036166123.1 → XP_036022016.1 neurabin-1 isoform X3

UniProtKB/TrEMBL

H3BL28

Conserved Domains (4) summary

cd09512
Location:1188 → 1257

SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily

smart00228
Location:502 → 593

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

TIGR02168
Location:659 → 904

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam17817
Location:435 → 498

PDZ_5; PDZ domain
XM_036166125.1 → XP_036022018.1 neurabin-1 isoform X7

UniProtKB/TrEMBL

H3BL28, Q7TN74

Conserved Domains (4) summary

cd09512
Location:983 → 1052

SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily

smart00228
Location:502 → 593

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

TIGR02168
Location:659 → 927

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam17817
Location:435 → 498

PDZ_5; PDZ domain
XM_036166127.1 → XP_036022020.1 neurabin-1 isoform X12

Conserved Domains (3) summary

cd09512
Location:667 → 736

SAM_Neurabin-like; SAM domain of SAM_Neurabin-like subfamily

cd00992
Location:10 → 68

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

TIGR02168
Location:138 → 383

SMC_prok_B; chromosome segregation protein SMC, common bacterial type