Dohh deoxyhypusine hydroxylase/monooxygenase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dohhprovided by MGI
Official Full Name: deoxyhypusine hydroxylase/monooxygenaseprovided by MGI
Primary source: MGI:MGI:1915964
See related: Ensembl:ENSMUSG00000078440 AllianceGenome:MGI:1915964
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hlrc1; 1110033C18Rik
Summary: Predicted to enable deoxyhypusine monooxygenase activity and iron ion binding activity. Acts upstream of or within peptidyl-lysine modification to peptidyl-hypusine. Is expressed in nervous system; retina; and skeletal muscle. Orthologous to human DOHH (deoxyhypusine hydroxylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 72.2), adrenal adult (RPKM 53.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (81220268..81224186)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (81384434..81388352)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deoxyhypusine hydroxylase: A novel therapeutic target differentially expressed in short-term vs long-term survivors of glioblastoma.
Title: Deoxyhypusine hydroxylase: A novel therapeutic target differentially expressed in short-term vs long-term survivors of glioblastoma.
Neuron-specific ablation of eIF5A or deoxyhypusine synthase leads to impairments in growth, viability, neurodevelopment, and cognitive functions in mice.
Title: Neuron-specific ablation of eIF5A or deoxyhypusine synthase leads to impairments in growth, viability, neurodevelopment, and cognitive functions in mice.
Deletion of hypusine modification enzymes ( deoxyhypusine synthase and deoxyhypusine hydroxylase )exerts strong phenotypes. eIF-5A2-deleted animals are viable and fertile.
Title: Biological Relevance and Therapeutic Potential of the Hypusine Modification System.
An evolutionarily conserved role for the DOHH-mediated second step of hypusine synthesis in early embryonic development, is reported.
Title: A novel mouse model for inhibition of DOHH-mediated hypusine modification reveals a crucial function in embryonic development, proliferation and oncogenic transformation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI585913 (e-PCR)
- UniSTS:179824

RH125369 (e-PCR)
- UniSTS:162191

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables deoxyhypusine monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables deoxyhypusine monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables iron ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in peptidyl-lysine modification to peptidyl-hypusine	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within peptidyl-lysine modification to peptidyl-hypusine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-lysine modification to peptidyl-hypusine	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: deoxyhypusine hydroxylase

Names: HEAT-like (PBS lyase) repeat containing 1; deoxyhypusine dioxygenase; deoxyhypusine monooxygenase

NP_598725.2

EC 1.14.99.29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133964.3 → NP_598725.2 deoxyhypusine hydroxylase

See identical proteins and their annotated locations for NP_598725.2

Status: VALIDATED

Source sequence(s)

AC155937

Consensus CDS

CCDS35997.1

UniProtKB/Swiss-Prot

Q8BNT3, Q8BTD5, Q99LN9

Related

ENSMUSP00000072534.7, ENSMUST00000072751.13

Conserved Domains (2) summary

COG1413
Location:37 → 292

HEAT; HEAT repeat [General function prediction only]

sd00044
Location:39 → 67

HEAT; HEAT repeat [structural motif]