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    H2-T26 histocompatibility 2, T region locus 26 [ Mus musculus (house mouse) ]

    Gene ID: 667977, updated on 8-Feb-2024

    Summary

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    Official Symbol
    H2-T26provided by MGI
    Official Full Name
    histocompatibility 2, T region locus 26provided by MGI
    Primary source
    MGI:MGI:3704134
    See related
    Ensembl:ENSMUSG00000073402 AllianceGenome:MGI:3704134
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H-2T5; H2-T5; Gm8909; H2-Tw5l; H2-gs17; EG667977
    Summary
    Predicted to enable peptide antigen binding activity and signaling receptor binding activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; and positive regulation of T cell mediated cytotoxicity. Predicted to be active in external side of plasma membrane and extracellular space. Human ortholog(s) of this gene implicated in several diseases, including Stevens-Johnson syndrome; asthma (multiple); autoimmune disease (multiple); eye disease (multiple); and inner ear disease (multiple). Orthologous to several human genes including HLA-E (major histocompatibility complex, class I, E); HLA-F (major histocompatibility complex, class I, F); and HLA-G (major histocompatibility complex, class I, G). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in duodenum adult (RPKM 70.8), small intestine adult (RPKM 58.6) and 13 other tissues See more
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    Genomic context

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    See H2-T26 in Genome Data Viewer
    Location:
    17 B1; 17 18.97 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (36454704..36479490, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (36143812..36168602, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene histocompatibility-2, T region locus 25 Neighboring gene histocompatibility 2, T region pseudogene Neighboring gene RIKEN cDNA 2410017I17 gene Neighboring gene predicted gene 10499 Neighboring gene akirin 1 pseudogene Neighboring gene akirin 1 pseudogene Neighboring gene histocompatibility 2, T region locus 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Major histocompatibility complex (Mhc) class Ib gene duplications, organization and expression patterns in mouse strain C57BL/6. Ohtsuka M, et al. BMC Genomics, 2008 Apr 17. PMID 18416856, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables peptide antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of T cell mediated cytotoxicity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein LOC667977
    Names
    MHC class I like protein GS17
    histocompatibility 2, T region locus 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081032.3 → NP_001074501.2  uncharacterized protein LOC667977 precursor

      See identical proteins and their annotated locations for NP_001074501.2

      Status: VALIDATED

      Source sequence(s)
      CT030728
      Consensus CDS
      CCDS37610.2
      UniProtKB/TrEMBL
      A7VMS6, E9Q0G4
      Related
      ENSMUSP00000036092.9, ENSMUST00000040467.15
      Conserved Domains (3) summary
      pfam00129
      Location:26 → 204
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
      cd00096
      Location:224 → 228
      Ig; Ig strand B [structural motif]
      cl11960
      Location:206 → 301
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      36454704..36479490 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246573.3 → XP_011244875.1  uncharacterized protein LOC667977 isoform X2

      Conserved Domains (1) summary
      pfam00129
      Location:55 → 232
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    2. XM_006524801.5 → XP_006524864.1  uncharacterized protein LOC667977 isoform X3

      UniProtKB/TrEMBL
      E9Q0G4
      Conserved Domains (3) summary
      cd07698
      Location:236 → 328
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00129
      Location:55 → 232
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
      pfam06623
      Location:371 → 396
      MHC_I_C; MHC_I C-terminus

    3. XM_006524804.4 → XP_006524867.1  uncharacterized protein LOC667977 isoform X4

      UniProtKB/TrEMBL
      E9Q0G4
      Conserved Domains (3) summary
      cd07698
      Location:208 → 300
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00129
      Location:27 → 204
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
      pfam06623
      Location:343 → 368
      MHC_I_C; MHC_I C-terminus

    4. XM_006524802.5 → XP_006524865.1  uncharacterized protein LOC667977 isoform X1

      UniProtKB/TrEMBL
      E9Q0G4, G3UXE9
      Related
      ENSMUSP00000133663.2, ENSMUST00000173353.8
      Conserved Domains (2) summary
      cd07698
      Location:236 → 328
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00129
      Location:55 → 232
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    5. XM_030249996.2 → XP_030105856.1  uncharacterized protein LOC667977 isoform X5

      Conserved Domains (2) summary
      cd07698
      Location:208 → 299
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      pfam00129
      Location:27 → 204
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    Nucleotide Protein Strain
    Heading Accession and Version

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