Smcp sperm mitochondria-associated cysteine-rich protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Smcpprovided by MGI
Official Full Name: sperm mitochondria-associated cysteine-rich proteinprovided by MGI
Primary source: MGI:MGI:96945
See related: Ensembl:ENSMUSG00000074435 AllianceGenome:MGI:96945
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mcs; Mcsp
Summary: Involved in flagellated sperm motility. Acts upstream of or within binding activity of sperm to zona pellucida and penetration of zona pellucida. Located in mitochondrion. Is expressed in testis. Orthologous to human SMCP (sperm mitochondria associated cysteine rich protein). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Note: There was a controversy about whether this gene encoded a selenoprotein, named mitochondrial capsule selenoprotein. A later study showed that not to be true and renamed it, sperm mitochondria-associated cysteine-rich protein (PMID:8916043). [04 Aug 2017]
Expression: Restricted expression toward testis adult (RPKM 1377.0) See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 40.14 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (92491173..92496380, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (92583866..92589073, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Smcp mRNA translation is regulated by multiple elements in the 5' UTR and 3' UTR.
Title: Identification of elements in the Smcp 5' and 3' UTR that repress translation and promote the formation of heavy inactive mRNPs in spermatids by analysis of mutations in transgenic mice.
The patterns of transcription and translation of the Smcp promoter and it's 5'UTR and 3' UTR
Title: The 5' UTR and 3' UTR of the sperm mitochondria-associated cysteine-rich protein mRNA regulate translation in spermatids by multiple mechanisms in transgenic mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

General gene information

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Markers

mMcsp (e-PCR)
- UniSTS:514583

PMC133774P1 (e-PCR)
- UniSTS:270662

Smcp (e-PCR), detects polymorphism
- UniSTS:526983

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within binding of sperm to zona pellucida	IGI Inferred from Genetic Interaction more info	PubMed
involved_in flagellated sperm motility	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within flagellated sperm motility	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within penetration of zona pellucida	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within penetration of zona pellucida	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within single fertilization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	TAS Traceable Author Statement more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: sperm mitochondrial-associated cysteine-rich protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.